5IVW

Human core TFIIH bound to DNA within the PIC

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
0	0000439	cellular_component	transcription factor TFIIH core complex
0	0002031	biological_process	G protein-coupled receptor internalization
0	0005515	molecular_function	protein binding
0	0005634	cellular_component	nucleus
0	0005654	cellular_component	nucleoplasm
0	0005669	cellular_component	transcription factor TFIID complex
0	0005675	cellular_component	transcription factor TFIIH holo complex
0	0006281	biological_process	DNA repair
0	0006289	biological_process	nucleotide-excision repair
0	0006351	biological_process	DNA-templated transcription
0	0006357	biological_process	regulation of transcription by RNA polymerase II
0	0006366	biological_process	transcription by RNA polymerase II
0	0006367	biological_process	transcription initiation at RNA polymerase II promoter
0	0008270	molecular_function	zinc ion binding
0	0009411	biological_process	response to UV
0	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
0	0016607	cellular_component	nuclear speck
0	0046872	molecular_function	metal ion binding
1	0000439	cellular_component	transcription factor TFIIH core complex
1	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
1	0005515	molecular_function	protein binding
1	0005634	cellular_component	nucleus
1	0005654	cellular_component	nucleoplasm
1	0005669	cellular_component	transcription factor TFIID complex
1	0005675	cellular_component	transcription factor TFIIH holo complex
1	0005730	cellular_component	nucleolus
1	0005737	cellular_component	cytoplasm
1	0006281	biological_process	DNA repair
1	0006289	biological_process	nucleotide-excision repair
1	0006294	biological_process	nucleotide-excision repair, preincision complex assembly
1	0006362	biological_process	transcription elongation by RNA polymerase I
1	0006366	biological_process	transcription by RNA polymerase II
1	0006367	biological_process	transcription initiation at RNA polymerase II promoter
1	0071480	biological_process	cellular response to gamma radiation
2	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
2	0000439	cellular_component	transcription factor TFIIH core complex
2	0001671	molecular_function	ATPase activator activity
2	0003690	molecular_function	double-stranded DNA binding
2	0005515	molecular_function	protein binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005669	cellular_component	transcription factor TFIID complex
2	0005675	cellular_component	transcription factor TFIIH holo complex
2	0006281	biological_process	DNA repair
2	0006289	biological_process	nucleotide-excision repair
2	0006366	biological_process	transcription by RNA polymerase II
2	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
2	0016607	cellular_component	nuclear speck
3	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
3	0000439	cellular_component	transcription factor TFIIH core complex
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005669	cellular_component	transcription factor TFIID complex
3	0005675	cellular_component	transcription factor TFIIH holo complex
3	0006281	biological_process	DNA repair
3	0006289	biological_process	nucleotide-excision repair
3	0006355	biological_process	regulation of DNA-templated transcription
3	0006366	biological_process	transcription by RNA polymerase II
3	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
3	0046872	molecular_function	metal ion binding
3	0097550	cellular_component	transcription preinitiation complex
V	0000112	cellular_component	nucleotide-excision repair factor 3 complex
V	0000439	cellular_component	transcription factor TFIIH core complex
V	0000717	biological_process	nucleotide-excision repair, DNA duplex unwinding
V	0001666	biological_process	response to hypoxia
V	0003677	molecular_function	DNA binding
V	0003678	molecular_function	DNA helicase activity
V	0003684	molecular_function	damaged DNA binding
V	0004386	molecular_function	helicase activity
V	0005515	molecular_function	protein binding
V	0005524	molecular_function	ATP binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005669	cellular_component	transcription factor TFIID complex
V	0005675	cellular_component	transcription factor TFIIH holo complex
V	0006265	biological_process	DNA topological change
V	0006281	biological_process	DNA repair
V	0006283	biological_process	transcription-coupled nucleotide-excision repair
V	0006289	biological_process	nucleotide-excision repair
V	0006366	biological_process	transcription by RNA polymerase II
V	0006367	biological_process	transcription initiation at RNA polymerase II promoter
V	0006368	biological_process	transcription elongation by RNA polymerase II
V	0006915	biological_process	apoptotic process
V	0006979	biological_process	response to oxidative stress
V	0008104	biological_process	protein localization
V	0009411	biological_process	response to UV
V	0009650	biological_process	UV protection
V	0016787	molecular_function	hydrolase activity
V	0016853	molecular_function	isomerase activity
V	0016887	molecular_function	ATP hydrolysis activity
V	0035315	biological_process	hair cell differentiation
V	0043065	biological_process	positive regulation of apoptotic process
V	0043138	molecular_function	3'-5' DNA helicase activity
V	0048568	biological_process	embryonic organ development
V	0097550	cellular_component	transcription preinitiation complex
V	0140640	molecular_function	catalytic activity, acting on a nucleic acid
V	1901990	biological_process	regulation of mitotic cell cycle phase transition
V	1990841	molecular_function	promoter-specific chromatin binding
W	0000439	cellular_component	transcription factor TFIIH core complex
W	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
W	0001666	biological_process	response to hypoxia
W	0001701	biological_process	in utero embryonic development
W	0003676	molecular_function	nucleic acid binding
W	0003677	molecular_function	DNA binding
W	0003678	molecular_function	DNA helicase activity
W	0003684	molecular_function	damaged DNA binding
W	0004386	molecular_function	helicase activity
W	0005515	molecular_function	protein binding
W	0005524	molecular_function	ATP binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005669	cellular_component	transcription factor TFIID complex
W	0005675	cellular_component	transcription factor TFIIH holo complex
W	0005737	cellular_component	cytoplasm
W	0005819	cellular_component	spindle
W	0005829	cellular_component	cytosol
W	0005856	cellular_component	cytoskeleton
W	0006139	biological_process	nucleobase-containing compound metabolic process
W	0006259	biological_process	DNA metabolic process
W	0006281	biological_process	DNA repair
W	0006283	biological_process	transcription-coupled nucleotide-excision repair
W	0006289	biological_process	nucleotide-excision repair
W	0006357	biological_process	regulation of transcription by RNA polymerase II
W	0006362	biological_process	transcription elongation by RNA polymerase I
W	0006366	biological_process	transcription by RNA polymerase II
W	0006367	biological_process	transcription initiation at RNA polymerase II promoter
W	0006915	biological_process	apoptotic process
W	0006974	biological_process	DNA damage response
W	0006979	biological_process	response to oxidative stress
W	0007059	biological_process	chromosome segregation
W	0008340	biological_process	determination of adult lifespan
W	0009411	biological_process	response to UV
W	0009650	biological_process	UV protection
W	0009791	biological_process	post-embryonic development
W	0016787	molecular_function	hydrolase activity
W	0016818	molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
W	0016887	molecular_function	ATP hydrolysis activity
W	0021510	biological_process	spinal cord development
W	0022405	biological_process	hair cycle process
W	0030198	biological_process	extracellular matrix organization
W	0030282	biological_process	bone mineralization
W	0030674	molecular_function	protein-macromolecule adaptor activity
W	0032289	biological_process	central nervous system myelin formation
W	0032508	biological_process	DNA duplex unwinding
W	0035264	biological_process	multicellular organism growth
W	0035315	biological_process	hair cell differentiation
W	0040016	biological_process	embryonic cleavage
W	0042274	biological_process	ribosomal small subunit biogenesis
W	0043139	molecular_function	5'-3' DNA helicase activity
W	0043249	biological_process	erythrocyte maturation
W	0043588	biological_process	skin development
W	0045951	biological_process	positive regulation of mitotic recombination
W	0046872	molecular_function	metal ion binding
W	0048009	biological_process	insulin-like growth factor receptor signaling pathway
W	0048568	biological_process	embryonic organ development
W	0048820	biological_process	hair follicle maturation
W	0051539	molecular_function	4 iron, 4 sulfur cluster binding
W	0060218	biological_process	hematopoietic stem cell differentiation
W	0070516	cellular_component	CAK-ERCC2 complex
W	0071425	biological_process	hematopoietic stem cell proliferation
W	0071817	cellular_component	MMXD complex
W	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
W	1901990	biological_process	regulation of mitotic cell cycle phase transition

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	21
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cav..CqnvFcvdcdvfvHdsl..H

Chain	Residue	Details
0	CYS360-HIS380

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site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. AvVVFDEAHN

Chain	Residue	Details
W	ALA229-ASN238

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	17
Details	ZN_FING: C4-type

Chain	Residue	Details
3	CYS268-CYS285

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:A0JN27

Chain	Residue	Details
0	TYR95
W	CYS134
W	CYS155

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
W	CYS190

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by CK2 => ECO:0000305|PubMed:15549133

Chain	Residue	Details
V	SER751

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