5IVG
Crystal structure of Aspergillus terreus aristolochene synthase N299A complexed with farnesyl thiolodiphosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0010333 | molecular_function | terpene synthase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016838 | molecular_function | carbon-oxygen lyase activity, acting on phosphates |
| A | 0045483 | molecular_function | aristolochene synthase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0010333 | molecular_function | terpene synthase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016838 | molecular_function | carbon-oxygen lyase activity, acting on phosphates |
| B | 0045483 | molecular_function | aristolochene synthase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0008299 | biological_process | isoprenoid biosynthetic process |
| C | 0010333 | molecular_function | terpene synthase activity |
| C | 0016829 | molecular_function | lyase activity |
| C | 0016838 | molecular_function | carbon-oxygen lyase activity, acting on phosphates |
| C | 0045483 | molecular_function | aristolochene synthase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0008299 | biological_process | isoprenoid biosynthetic process |
| D | 0010333 | molecular_function | terpene synthase activity |
| D | 0016829 | molecular_function | lyase activity |
| D | 0016838 | molecular_function | carbon-oxygen lyase activity, acting on phosphates |
| D | 0045483 | molecular_function | aristolochene synthase activity |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 701 |
| Chain | Residue |
| A | ASP84 |
| A | MG702 |
| A | FPS704 |
| A | HOH830 |
| A | HOH852 |
| A | HOH980 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 702 |
| Chain | Residue |
| A | HOH834 |
| A | HOH940 |
| A | HOH943 |
| A | HOH980 |
| A | ASP84 |
| A | MG701 |
| A | FPS704 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 703 |
| Chain | Residue |
| A | ASN213 |
| A | SER217 |
| A | GLU221 |
| A | FPS704 |
| A | HOH881 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | binding site for residue FPS A 704 |
| Chain | Residue |
| A | TYR61 |
| A | PHE81 |
| A | ASP84 |
| A | PHE147 |
| A | ARG169 |
| A | ASN213 |
| A | SER217 |
| A | LYS220 |
| A | GLU221 |
| A | TRP302 |
| A | ARG308 |
| A | TYR309 |
| A | MG701 |
| A | MG702 |
| A | MG703 |
| A | HOH830 |
| A | HOH852 |
| A | HOH953 |
| A | HOH980 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 705 |
| Chain | Residue |
| A | TYR216 |
| A | GLN304 |
| A | SER310 |
| A | HOH814 |
| A | HOH905 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 701 |
| Chain | Residue |
| B | ASP84 |
| B | MG702 |
| B | FPS704 |
| B | HOH843 |
| B | HOH879 |
| B | HOH993 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue MG B 702 |
| Chain | Residue |
| B | ASP84 |
| B | MG701 |
| B | FPS704 |
| B | HOH840 |
| B | HOH971 |
| B | HOH993 |
| B | HOH1054 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 703 |
| Chain | Residue |
| B | ASN213 |
| B | SER217 |
| B | GLU221 |
| B | FPS704 |
| B | HOH885 |
| site_id | AC9 |
| Number of Residues | 20 |
| Details | binding site for residue FPS B 704 |
| Chain | Residue |
| B | TYR61 |
| B | PHE81 |
| B | ASP84 |
| B | PHE147 |
| B | ARG169 |
| B | ASN213 |
| B | SER217 |
| B | LYS220 |
| B | GLU221 |
| B | TRP302 |
| B | ARG308 |
| B | TYR309 |
| B | MG701 |
| B | MG702 |
| B | MG703 |
| B | HOH840 |
| B | HOH843 |
| B | HOH857 |
| B | HOH879 |
| B | HOH993 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 705 |
| Chain | Residue |
| B | ARG107 |
| B | GLU142 |
| B | ARG149 |
| B | HOH854 |
| B | HOH930 |
| C | ARG197 |
| C | GLU200 |
| C | LEU275 |
| C | HOH939 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 701 |
| Chain | Residue |
| C | ASP84 |
| C | MG702 |
| C | FPS704 |
| C | HOH809 |
| C | HOH889 |
| C | HOH968 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue MG C 702 |
| Chain | Residue |
| C | HOH906 |
| C | HOH930 |
| C | HOH968 |
| C | ASP84 |
| C | MG701 |
| C | FPS704 |
| C | HOH822 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue MG C 703 |
| Chain | Residue |
| C | ASN213 |
| C | SER217 |
| C | GLU221 |
| C | FPS704 |
| C | HOH878 |
| site_id | AD5 |
| Number of Residues | 19 |
| Details | binding site for residue FPS C 704 |
| Chain | Residue |
| C | TYR61 |
| C | PHE81 |
| C | ASP84 |
| C | PHE147 |
| C | ARG169 |
| C | ASN213 |
| C | SER217 |
| C | LYS220 |
| C | GLU221 |
| C | ARG308 |
| C | TYR309 |
| C | MG701 |
| C | MG702 |
| C | MG703 |
| C | HOH809 |
| C | HOH822 |
| C | HOH839 |
| C | HOH889 |
| C | HOH968 |
| site_id | AD6 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 705 |
| Chain | Residue |
| B | ARG197 |
| B | LEU280 |
| B | HOH985 |
| C | ARG107 |
| C | GLU142 |
| C | ARG149 |
| C | HOH853 |
| C | HOH980 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue MG D 701 |
| Chain | Residue |
| D | ASP84 |
| D | MG702 |
| D | FPS704 |
| D | HOH843 |
| D | HOH844 |
| D | HOH848 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue MG D 702 |
| Chain | Residue |
| D | ASP84 |
| D | MG701 |
| D | FPS704 |
| D | HOH823 |
| D | HOH848 |
| D | HOH873 |
| D | HOH944 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue MG D 703 |
| Chain | Residue |
| D | ASN213 |
| D | SER217 |
| D | GLU221 |
| D | FPS704 |
| D | HOH841 |
| site_id | AE1 |
| Number of Residues | 20 |
| Details | binding site for residue FPS D 704 |
| Chain | Residue |
| D | TYR61 |
| D | PHE81 |
| D | ASP84 |
| D | PHE147 |
| D | ARG169 |
| D | VAL173 |
| D | ASN213 |
| D | SER217 |
| D | LYS220 |
| D | GLU221 |
| D | ARG308 |
| D | TYR309 |
| D | MG701 |
| D | MG702 |
| D | MG703 |
| D | HOH805 |
| D | HOH823 |
| D | HOH843 |
| D | HOH844 |
| D | HOH848 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17261032, ECO:0000269|PubMed:18385128 |
| Chain | Residue | Details |
| A | ASP84 | |
| B | ASP84 | |
| C | ASP84 | |
| D | ASP84 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17261032, ECO:0000269|PubMed:18385128, ECO:0007744|PDB:3BNX |
| Chain | Residue | Details |
| A | ASN213 | |
| D | ASN213 | |
| D | SER217 | |
| D | GLU221 | |
| A | SER217 | |
| A | GLU221 | |
| B | ASN213 | |
| B | SER217 | |
| B | GLU221 | |
| C | ASN213 | |
| C | SER217 | |
| C | GLU221 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18385128, ECO:0007744|PDB:3BNX |
| Chain | Residue | Details |
| A | ARG308 | |
| A | TYR309 | |
| B | ARG308 | |
| B | TYR309 | |
| C | ARG308 | |
| C | TYR309 | |
| D | ARG308 | |
| D | TYR309 |
