5IUE

Human leukocyte antigen F (HLA-F) presents peptides and regulates immunity through interactions with NK-cell receptors

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0006955	biological_process	immune response
B	0042612	cellular_component	MHC class I protein complex
F	0006955	biological_process	immune response
F	0042612	cellular_component	MHC class I protein complex
H	0006955	biological_process	immune response
H	0042612	cellular_component	MHC class I protein complex
J	0006955	biological_process	immune response
J	0042612	cellular_component	MHC class I protein complex

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH

Chain	Residue	Details
A	TYR257-HIS263
B	TYR78-HIS84

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	360
Details	Domain: {"description":"Ig-like C1-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

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site_id	SWS_FT_FI3
Number of Residues	364
Details	Region: {"description":"Alpha-2"}

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site_id	SWS_FT_FI4
Number of Residues	364
Details	Region: {"description":"Alpha-3"}

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site_id	SWS_FT_FI5
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28636952","evidenceCode":"ECO:0000269"}]}

Chain

Residue

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site_id	SWS_FT_FI6
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000250"}]}

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Residue

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site_id	SWS_FT_FI7
Number of Residues	89
Details	Region: {"description":"Alpha-1"}

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Residue

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site_id	SWS_FT_FI8
Number of Residues	352
Details	Domain: {"description":"Ig-like C1-type"}

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site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid; in form pI 5.3","evidences":[{"source":"PubMed","id":"7554280","evidenceCode":"ECO:0000269"}]}

Chain

Residue

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site_id	SWS_FT_FI10
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI11
Number of Residues	24
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

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