5IU9

Crystal Structure of Zebrafish Protocadherin-19 EC1-4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0005886	cellular_component	plasma membrane
A	0007155	biological_process	cell adhesion
A	0007156	biological_process	homophilic cell-cell adhesion
A	0016020	cellular_component	membrane
B	0005509	molecular_function	calcium ion binding
B	0005886	cellular_component	plasma membrane
B	0007155	biological_process	cell adhesion
B	0007156	biological_process	homophilic cell-cell adhesion
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue CA A 1001

Chain	Residue
A	GLU10
A	GLU11
A	ASP65
A	ASP67
A	ASP101

---

site_id	AC2
Number of Residues	6
Details	binding site for residue CA A 1002

Chain	Residue
A	ASP101
A	ASP134
A	GLU10
A	ASP67
A	ASP98
A	VAL99

---

site_id	AC3
Number of Residues	6
Details	binding site for residue CA A 1003

Chain	Residue
A	ASN100
A	ASN102
A	ASP132
A	ASP134
A	ASN138
A	ASP189

---

site_id	AC4
Number of Residues	4
Details	binding site for residue CA A 1004

Chain	Residue
A	GLU117
A	ASP174
A	GLU176
A	ASP210

---

site_id	AC5
Number of Residues	6
Details	binding site for residue CA A 1005

Chain	Residue
A	GLU117
A	GLU176
A	ASP207
A	SER208
A	ASP210
A	ASP243

---

site_id	AC6
Number of Residues	6
Details	binding site for residue CA A 1006

Chain	Residue
A	ASN209
A	ASN211
A	ASP241
A	ASP243
A	ASN247
A	ASP297

---

site_id	AC7
Number of Residues	5
Details	binding site for residue CA A 1007

Chain	Residue
A	GLU226
A	ASP282
A	GLU284
A	ASP318
A	ASN319

---

site_id	AC8
Number of Residues	6
Details	binding site for residue CA A 1008

Chain	Residue
A	GLU226
A	GLU284
A	ASP315
A	ILE316
A	ASP318
A	ASP354

---

site_id	AC9
Number of Residues	6
Details	binding site for residue CA A 1009

Chain	Residue
A	ASN317
A	ASN319
A	ASP352
A	ASP354
A	ASN358
A	ASP404

---

site_id	AD1
Number of Residues	4
Details	binding site for residue NA A 1010

Chain	Residue
A	ASP236
A	LEU237
A	ASN238
A	THR272

---

site_id	AD2
Number of Residues	5
Details	binding site for residue CA B 1001

Chain	Residue
B	GLU10
B	GLU11
B	ASP65
B	ASP67
B	ASP101

---

site_id	AD3
Number of Residues	6
Details	binding site for residue CA B 1002

Chain	Residue
B	GLU10
B	ASP67
B	ASP98
B	VAL99
B	ASP101
B	ASP134

---

site_id	AD4
Number of Residues	6
Details	binding site for residue CA B 1003

Chain	Residue
B	ASN100
B	ASN102
B	ASP132
B	ASP134
B	ASN138
B	ASP189

---

site_id	AD5
Number of Residues	4
Details	binding site for residue CA B 1004

Chain	Residue
B	GLU117
B	ASP174
B	GLU176
B	ASP210

---

site_id	AD6
Number of Residues	6
Details	binding site for residue CA B 1005

Chain	Residue
B	GLU117
B	GLU176
B	ASP207
B	SER208
B	ASP210
B	ASP243

---

site_id	AD7
Number of Residues	6
Details	binding site for residue CA B 1006

Chain	Residue
B	ASN209
B	ASN211
B	ASP241
B	ASP243
B	ASN247
B	ASP297

---

site_id	AD8
Number of Residues	5
Details	binding site for residue CA B 1007

Chain	Residue
B	GLU226
B	ASP282
B	GLU284
B	ASP318
B	ASN319

---

site_id	AD9
Number of Residues	6
Details	binding site for residue CA B 1008

Chain	Residue
B	GLU226
B	GLU284
B	ASP315
B	ILE316
B	ASP318
B	ASP354

---

site_id	AE1
Number of Residues	7
Details	binding site for residue CA B 1009

Chain	Residue
B	ASN319
B	ALA320
B	ASP352
B	ASP354
B	ASN358
B	ASP404
B	ASN317

---

site_id	AE2
Number of Residues	4
Details	binding site for residue NA B 1010

Chain	Residue
B	ASP236
B	LEU237
B	ASN238
B	THR272

---

Functional Information from PROSITE/UniProt

site_id	PS00232
Number of Residues	11
Details	CADHERIN_1 Cadherin domain signature. IeIiDvNDNaP

Chain	Residue	Details
A	ILE94-PRO104
A	ILE203-PRO213
A	VAL311-PRO321

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	216
Details	Domain: {"description":"Cadherin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00043","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	214
Details	Domain: {"description":"Cadherin 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00043","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	46
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27787195","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IU9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27787195","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34520737","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PGW","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"5IU9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34520737","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PGW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	10
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	99
Details	Domain: {"description":"Cadherin 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00043","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---