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5ITU

Crystal Structure of Human NEIL1(242K) bound to duplex DNA containing THF

Functional Information from GO Data
ChainGOidnamespacecontents
A0003676molecular_functionnucleic acid binding
A0003677molecular_functionDNA binding
A0003684molecular_functiondamaged DNA binding
A0003906molecular_functionDNA-(apurinic or apyrimidinic site) endonuclease activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0006281biological_processDNA repair
A0006284biological_processbase-excision repair
A0006287biological_processbase-excision repair, gap-filling
A0006979biological_processresponse to oxidative stress
A0008270molecular_functionzinc ion binding
A0016798molecular_functionhydrolase activity, acting on glycosyl bonds
A0016799molecular_functionhydrolase activity, hydrolyzing N-glycosyl compounds
A0016829molecular_functionlyase activity
A0019104molecular_functionDNA N-glycosylase activity
A0032074biological_processnegative regulation of nuclease activity
A0045008biological_processdepyrimidination
A0140078molecular_functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
B0003676molecular_functionnucleic acid binding
B0003677molecular_functionDNA binding
B0003684molecular_functiondamaged DNA binding
B0003906molecular_functionDNA-(apurinic or apyrimidinic site) endonuclease activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0006281biological_processDNA repair
B0006284biological_processbase-excision repair
B0006287biological_processbase-excision repair, gap-filling
B0006979biological_processresponse to oxidative stress
B0008270molecular_functionzinc ion binding
B0016798molecular_functionhydrolase activity, acting on glycosyl bonds
B0016799molecular_functionhydrolase activity, hydrolyzing N-glycosyl compounds
B0016829molecular_functionlyase activity
B0019104molecular_functionDNA N-glycosylase activity
B0032074biological_processnegative regulation of nuclease activity
B0045008biological_processdepyrimidination
B0140078molecular_functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
C0003676molecular_functionnucleic acid binding
C0003677molecular_functionDNA binding
C0003684molecular_functiondamaged DNA binding
C0003906molecular_functionDNA-(apurinic or apyrimidinic site) endonuclease activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005694cellular_componentchromosome
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0006281biological_processDNA repair
C0006284biological_processbase-excision repair
C0006287biological_processbase-excision repair, gap-filling
C0006979biological_processresponse to oxidative stress
C0008270molecular_functionzinc ion binding
C0016798molecular_functionhydrolase activity, acting on glycosyl bonds
C0016799molecular_functionhydrolase activity, hydrolyzing N-glycosyl compounds
C0016829molecular_functionlyase activity
C0019104molecular_functionDNA N-glycosylase activity
C0032074biological_processnegative regulation of nuclease activity
C0045008biological_processdepyrimidination
C0140078molecular_functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Schiff-base intermediate with DNA => ECO:0000305
ChainResidueDetails
APRO2
BPRO2
CPRO2

site_idSWS_FT_FI2
Number of Residues3
DetailsACT_SITE: Proton donor => ECO:0000305
ChainResidueDetails
AGLU3
BGLU3
CGLU3

site_idSWS_FT_FI3
Number of Residues3
DetailsACT_SITE: Proton donor; for beta-elimination activity => ECO:0000305
ChainResidueDetails
ALYS54
BLYS54
CLYS54

site_idSWS_FT_FI4
Number of Residues3
DetailsACT_SITE: Proton donor; for delta-elimination activity => ECO:0000305
ChainResidueDetails
AARG339
BARG339
CARG339

site_idSWS_FT_FI5
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AASN176
AARG339
BASN176
BARG339
CASN176
CARG339

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PDB entries from 2024-07-24

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