5IRO

Crystal structure of a complex between the Human adenovirus type 4 E3-19K protein and MHC class molecule HLA-A2/TAX

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000139	cellular_component	Golgi membrane
C	0002376	biological_process	immune system process
C	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
C	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
C	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
C	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
C	0002715	biological_process	regulation of natural killer cell mediated immunity
C	0002726	biological_process	positive regulation of T cell cytokine production
C	0005198	molecular_function	structural molecule activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005765	cellular_component	lysosomal membrane
C	0005783	cellular_component	endoplasmic reticulum
C	0005788	cellular_component	endoplasmic reticulum lumen
C	0005794	cellular_component	Golgi apparatus
C	0005886	cellular_component	plasma membrane
C	0005925	cellular_component	focal adhesion
C	0006879	biological_process	intracellular iron ion homeostasis
C	0006955	biological_process	immune response
C	0007608	biological_process	sensory perception of smell
C	0007611	biological_process	learning or memory
C	0009897	cellular_component	external side of plasma membrane
C	0009986	cellular_component	cell surface
C	0010038	biological_process	response to metal ion
C	0012507	cellular_component	ER to Golgi transport vesicle membrane
C	0016020	cellular_component	membrane
C	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
C	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
C	0023026	molecular_function	MHC class II protein complex binding
C	0030670	cellular_component	phagocytic vesicle membrane
C	0031901	cellular_component	early endosome membrane
C	0031902	cellular_component	late endosome membrane
C	0031905	cellular_component	early endosome lumen
C	0033572	biological_process	transferrin transport
C	0034756	biological_process	regulation of iron ion transport
C	0034757	biological_process	negative regulation of iron ion transport
C	0035580	cellular_component	specific granule lumen
C	0042605	molecular_function	peptide antigen binding
C	0042612	cellular_component	MHC class I protein complex
C	0042613	cellular_component	MHC class II protein complex
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0042824	cellular_component	MHC class I peptide loading complex
C	0048260	biological_process	positive regulation of receptor-mediated endocytosis
C	0048261	biological_process	negative regulation of receptor-mediated endocytosis
C	0050680	biological_process	negative regulation of epithelial cell proliferation
C	0050768	biological_process	negative regulation of neurogenesis
C	0050778	biological_process	positive regulation of immune response
C	0050870	biological_process	positive regulation of T cell activation
C	0051289	biological_process	protein homotetramerization
C	0055038	cellular_component	recycling endosome membrane
C	0070062	cellular_component	extracellular exosome
C	0071281	biological_process	cellular response to iron ion
C	0071316	biological_process	cellular response to nicotine
C	1904724	cellular_component	tertiary granule lumen
C	1990000	biological_process	amyloid fibril formation
C	1990712	cellular_component	HFE-transferrin receptor complex
C	2000774	biological_process	positive regulation of cellular senescence
C	2000978	biological_process	negative regulation of forebrain neuron differentiation
D	0005537	molecular_function	D-mannose binding
D	0052031	biological_process	symbiont-mediated perturbation of host defense response
G	0000139	cellular_component	Golgi membrane
G	0002376	biological_process	immune system process
G	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
G	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
G	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
G	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
G	0002715	biological_process	regulation of natural killer cell mediated immunity
G	0002726	biological_process	positive regulation of T cell cytokine production
G	0005198	molecular_function	structural molecule activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005765	cellular_component	lysosomal membrane
G	0005783	cellular_component	endoplasmic reticulum
G	0005788	cellular_component	endoplasmic reticulum lumen
G	0005794	cellular_component	Golgi apparatus
G	0005886	cellular_component	plasma membrane
G	0005925	cellular_component	focal adhesion
G	0006879	biological_process	intracellular iron ion homeostasis
G	0006955	biological_process	immune response
G	0007608	biological_process	sensory perception of smell
G	0007611	biological_process	learning or memory
G	0009897	cellular_component	external side of plasma membrane
G	0009986	cellular_component	cell surface
G	0010038	biological_process	response to metal ion
G	0012507	cellular_component	ER to Golgi transport vesicle membrane
G	0016020	cellular_component	membrane
G	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
G	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
G	0023026	molecular_function	MHC class II protein complex binding
G	0030670	cellular_component	phagocytic vesicle membrane
G	0031901	cellular_component	early endosome membrane
G	0031902	cellular_component	late endosome membrane
G	0031905	cellular_component	early endosome lumen
G	0033572	biological_process	transferrin transport
G	0034756	biological_process	regulation of iron ion transport
G	0034757	biological_process	negative regulation of iron ion transport
G	0035580	cellular_component	specific granule lumen
G	0042605	molecular_function	peptide antigen binding
G	0042612	cellular_component	MHC class I protein complex
G	0042613	cellular_component	MHC class II protein complex
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0042824	cellular_component	MHC class I peptide loading complex
G	0048260	biological_process	positive regulation of receptor-mediated endocytosis
G	0048261	biological_process	negative regulation of receptor-mediated endocytosis
G	0050680	biological_process	negative regulation of epithelial cell proliferation
G	0050768	biological_process	negative regulation of neurogenesis
G	0050778	biological_process	positive regulation of immune response
G	0050870	biological_process	positive regulation of T cell activation
G	0051289	biological_process	protein homotetramerization
G	0055038	cellular_component	recycling endosome membrane
G	0070062	cellular_component	extracellular exosome
G	0071281	biological_process	cellular response to iron ion
G	0071316	biological_process	cellular response to nicotine
G	1904724	cellular_component	tertiary granule lumen
G	1990000	biological_process	amyloid fibril formation
G	1990712	cellular_component	HFE-transferrin receptor complex
G	2000774	biological_process	positive regulation of cellular senescence
G	2000978	biological_process	negative regulation of forebrain neuron differentiation
H	0005537	molecular_function	D-mannose binding
H	0052031	biological_process	symbiont-mediated perturbation of host defense response
K	0000139	cellular_component	Golgi membrane
K	0002376	biological_process	immune system process
K	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
K	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
K	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
K	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
K	0002715	biological_process	regulation of natural killer cell mediated immunity
K	0002726	biological_process	positive regulation of T cell cytokine production
K	0005198	molecular_function	structural molecule activity
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0005765	cellular_component	lysosomal membrane
K	0005783	cellular_component	endoplasmic reticulum
K	0005788	cellular_component	endoplasmic reticulum lumen
K	0005794	cellular_component	Golgi apparatus
K	0005886	cellular_component	plasma membrane
K	0005925	cellular_component	focal adhesion
K	0006879	biological_process	intracellular iron ion homeostasis
K	0006955	biological_process	immune response
K	0007608	biological_process	sensory perception of smell
K	0007611	biological_process	learning or memory
K	0009897	cellular_component	external side of plasma membrane
K	0009986	cellular_component	cell surface
K	0010038	biological_process	response to metal ion
K	0012507	cellular_component	ER to Golgi transport vesicle membrane
K	0016020	cellular_component	membrane
K	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
K	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
K	0023026	molecular_function	MHC class II protein complex binding
K	0030670	cellular_component	phagocytic vesicle membrane
K	0031901	cellular_component	early endosome membrane
K	0031902	cellular_component	late endosome membrane
K	0031905	cellular_component	early endosome lumen
K	0033572	biological_process	transferrin transport
K	0034756	biological_process	regulation of iron ion transport
K	0034757	biological_process	negative regulation of iron ion transport
K	0035580	cellular_component	specific granule lumen
K	0042605	molecular_function	peptide antigen binding
K	0042612	cellular_component	MHC class I protein complex
K	0042613	cellular_component	MHC class II protein complex
K	0042802	molecular_function	identical protein binding
K	0042803	molecular_function	protein homodimerization activity
K	0042824	cellular_component	MHC class I peptide loading complex
K	0048260	biological_process	positive regulation of receptor-mediated endocytosis
K	0048261	biological_process	negative regulation of receptor-mediated endocytosis
K	0050680	biological_process	negative regulation of epithelial cell proliferation
K	0050768	biological_process	negative regulation of neurogenesis
K	0050778	biological_process	positive regulation of immune response
K	0050870	biological_process	positive regulation of T cell activation
K	0051289	biological_process	protein homotetramerization
K	0055038	cellular_component	recycling endosome membrane
K	0070062	cellular_component	extracellular exosome
K	0071281	biological_process	cellular response to iron ion
K	0071316	biological_process	cellular response to nicotine
K	1904724	cellular_component	tertiary granule lumen
K	1990000	biological_process	amyloid fibril formation
K	1990712	cellular_component	HFE-transferrin receptor complex
K	2000774	biological_process	positive regulation of cellular senescence
K	2000978	biological_process	negative regulation of forebrain neuron differentiation
L	0005537	molecular_function	D-mannose binding
L	0052031	biological_process	symbiont-mediated perturbation of host defense response
O	0000139	cellular_component	Golgi membrane
O	0002376	biological_process	immune system process
O	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
O	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
O	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
O	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
O	0002715	biological_process	regulation of natural killer cell mediated immunity
O	0002726	biological_process	positive regulation of T cell cytokine production
O	0005198	molecular_function	structural molecule activity
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005615	cellular_component	extracellular space
O	0005765	cellular_component	lysosomal membrane
O	0005783	cellular_component	endoplasmic reticulum
O	0005788	cellular_component	endoplasmic reticulum lumen
O	0005794	cellular_component	Golgi apparatus
O	0005886	cellular_component	plasma membrane
O	0005925	cellular_component	focal adhesion
O	0006879	biological_process	intracellular iron ion homeostasis
O	0006955	biological_process	immune response
O	0007608	biological_process	sensory perception of smell
O	0007611	biological_process	learning or memory
O	0009897	cellular_component	external side of plasma membrane
O	0009986	cellular_component	cell surface
O	0010038	biological_process	response to metal ion
O	0012507	cellular_component	ER to Golgi transport vesicle membrane
O	0016020	cellular_component	membrane
O	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
O	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
O	0023026	molecular_function	MHC class II protein complex binding
O	0030670	cellular_component	phagocytic vesicle membrane
O	0031901	cellular_component	early endosome membrane
O	0031902	cellular_component	late endosome membrane
O	0031905	cellular_component	early endosome lumen
O	0033572	biological_process	transferrin transport
O	0034756	biological_process	regulation of iron ion transport
O	0034757	biological_process	negative regulation of iron ion transport
O	0035580	cellular_component	specific granule lumen
O	0042605	molecular_function	peptide antigen binding
O	0042612	cellular_component	MHC class I protein complex
O	0042613	cellular_component	MHC class II protein complex
O	0042802	molecular_function	identical protein binding
O	0042803	molecular_function	protein homodimerization activity
O	0042824	cellular_component	MHC class I peptide loading complex
O	0048260	biological_process	positive regulation of receptor-mediated endocytosis
O	0048261	biological_process	negative regulation of receptor-mediated endocytosis
O	0050680	biological_process	negative regulation of epithelial cell proliferation
O	0050768	biological_process	negative regulation of neurogenesis
O	0050778	biological_process	positive regulation of immune response
O	0050870	biological_process	positive regulation of T cell activation
O	0051289	biological_process	protein homotetramerization
O	0055038	cellular_component	recycling endosome membrane
O	0070062	cellular_component	extracellular exosome
O	0071281	biological_process	cellular response to iron ion
O	0071316	biological_process	cellular response to nicotine
O	1904724	cellular_component	tertiary granule lumen
O	1990000	biological_process	amyloid fibril formation
O	1990712	cellular_component	HFE-transferrin receptor complex
O	2000774	biological_process	positive regulation of cellular senescence
O	2000978	biological_process	negative regulation of forebrain neuron differentiation
P	0005537	molecular_function	D-mannose binding
P	0052031	biological_process	symbiont-mediated perturbation of host defense response
S	0000139	cellular_component	Golgi membrane
S	0002376	biological_process	immune system process
S	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
S	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
S	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
S	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
S	0002715	biological_process	regulation of natural killer cell mediated immunity
S	0002726	biological_process	positive regulation of T cell cytokine production
S	0005198	molecular_function	structural molecule activity
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005615	cellular_component	extracellular space
S	0005765	cellular_component	lysosomal membrane
S	0005783	cellular_component	endoplasmic reticulum
S	0005788	cellular_component	endoplasmic reticulum lumen
S	0005794	cellular_component	Golgi apparatus
S	0005886	cellular_component	plasma membrane
S	0005925	cellular_component	focal adhesion
S	0006879	biological_process	intracellular iron ion homeostasis
S	0006955	biological_process	immune response
S	0007608	biological_process	sensory perception of smell
S	0007611	biological_process	learning or memory
S	0009897	cellular_component	external side of plasma membrane
S	0009986	cellular_component	cell surface
S	0010038	biological_process	response to metal ion
S	0012507	cellular_component	ER to Golgi transport vesicle membrane
S	0016020	cellular_component	membrane
S	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
S	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
S	0023026	molecular_function	MHC class II protein complex binding
S	0030670	cellular_component	phagocytic vesicle membrane
S	0031901	cellular_component	early endosome membrane
S	0031902	cellular_component	late endosome membrane
S	0031905	cellular_component	early endosome lumen
S	0033572	biological_process	transferrin transport
S	0034756	biological_process	regulation of iron ion transport
S	0034757	biological_process	negative regulation of iron ion transport
S	0035580	cellular_component	specific granule lumen
S	0042605	molecular_function	peptide antigen binding
S	0042612	cellular_component	MHC class I protein complex
S	0042613	cellular_component	MHC class II protein complex
S	0042802	molecular_function	identical protein binding
S	0042803	molecular_function	protein homodimerization activity
S	0042824	cellular_component	MHC class I peptide loading complex
S	0048260	biological_process	positive regulation of receptor-mediated endocytosis
S	0048261	biological_process	negative regulation of receptor-mediated endocytosis
S	0050680	biological_process	negative regulation of epithelial cell proliferation
S	0050768	biological_process	negative regulation of neurogenesis
S	0050778	biological_process	positive regulation of immune response
S	0050870	biological_process	positive regulation of T cell activation
S	0051289	biological_process	protein homotetramerization
S	0055038	cellular_component	recycling endosome membrane
S	0070062	cellular_component	extracellular exosome
S	0071281	biological_process	cellular response to iron ion
S	0071316	biological_process	cellular response to nicotine
S	1904724	cellular_component	tertiary granule lumen
S	1990000	biological_process	amyloid fibril formation
S	1990712	cellular_component	HFE-transferrin receptor complex
S	2000774	biological_process	positive regulation of cellular senescence
S	2000978	biological_process	negative regulation of forebrain neuron differentiation
T	0005537	molecular_function	D-mannose binding
T	0052031	biological_process	symbiont-mediated perturbation of host defense response
W	0000139	cellular_component	Golgi membrane
W	0002376	biological_process	immune system process
W	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
W	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
W	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
W	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
W	0002715	biological_process	regulation of natural killer cell mediated immunity
W	0002726	biological_process	positive regulation of T cell cytokine production
W	0005198	molecular_function	structural molecule activity
W	0005515	molecular_function	protein binding
W	0005576	cellular_component	extracellular region
W	0005615	cellular_component	extracellular space
W	0005765	cellular_component	lysosomal membrane
W	0005783	cellular_component	endoplasmic reticulum
W	0005788	cellular_component	endoplasmic reticulum lumen
W	0005794	cellular_component	Golgi apparatus
W	0005886	cellular_component	plasma membrane
W	0005925	cellular_component	focal adhesion
W	0006879	biological_process	intracellular iron ion homeostasis
W	0006955	biological_process	immune response
W	0007608	biological_process	sensory perception of smell
W	0007611	biological_process	learning or memory
W	0009897	cellular_component	external side of plasma membrane
W	0009986	cellular_component	cell surface
W	0010038	biological_process	response to metal ion
W	0012507	cellular_component	ER to Golgi transport vesicle membrane
W	0016020	cellular_component	membrane
W	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
W	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
W	0023026	molecular_function	MHC class II protein complex binding
W	0030670	cellular_component	phagocytic vesicle membrane
W	0031901	cellular_component	early endosome membrane
W	0031902	cellular_component	late endosome membrane
W	0031905	cellular_component	early endosome lumen
W	0033572	biological_process	transferrin transport
W	0034756	biological_process	regulation of iron ion transport
W	0034757	biological_process	negative regulation of iron ion transport
W	0035580	cellular_component	specific granule lumen
W	0042605	molecular_function	peptide antigen binding
W	0042612	cellular_component	MHC class I protein complex
W	0042613	cellular_component	MHC class II protein complex
W	0042802	molecular_function	identical protein binding
W	0042803	molecular_function	protein homodimerization activity
W	0042824	cellular_component	MHC class I peptide loading complex
W	0048260	biological_process	positive regulation of receptor-mediated endocytosis
W	0048261	biological_process	negative regulation of receptor-mediated endocytosis
W	0050680	biological_process	negative regulation of epithelial cell proliferation
W	0050768	biological_process	negative regulation of neurogenesis
W	0050778	biological_process	positive regulation of immune response
W	0050870	biological_process	positive regulation of T cell activation
W	0051289	biological_process	protein homotetramerization
W	0055038	cellular_component	recycling endosome membrane
W	0070062	cellular_component	extracellular exosome
W	0071281	biological_process	cellular response to iron ion
W	0071316	biological_process	cellular response to nicotine
W	1904724	cellular_component	tertiary granule lumen
W	1990000	biological_process	amyloid fibril formation
W	1990712	cellular_component	HFE-transferrin receptor complex
W	2000774	biological_process	positive regulation of cellular senescence
W	2000978	biological_process	negative regulation of forebrain neuron differentiation
X	0005537	molecular_function	D-mannose binding
X	0052031	biological_process	symbiont-mediated perturbation of host defense response

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH

Chain	Residue	Details
C	TYR78-HIS84
A	TYR257-HIS263

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	356
Details	Region: {"description":"Alpha-1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	546
Details	Region: {"description":"Alpha-2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21943705","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21543847","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"Sulfotyrosine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	5
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid; in form pI 5.3","evidences":[{"source":"PubMed","id":"7554280","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	36
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	440
Details	Domain: {"description":"Ig-like C1-type"}

Chain

Residue

Details

---