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5IRC

p190A GAP domain complex with RhoA

Functional Information from GO Data
ChainGOidnamespacecontents
A0007165biological_processsignal transduction
B0007165biological_processsignal transduction
D0000902biological_processcell morphogenesis
D0001764biological_processneuron migration
D0001822biological_processkidney development
D0001998biological_processangiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
D0002363biological_processalpha-beta T cell lineage commitment
D0003100biological_processregulation of systemic arterial blood pressure by endothelin
D0003189biological_processaortic valve formation
D0003924molecular_functionGTPase activity
D0003925molecular_functionG protein activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005768cellular_componentendosome
D0005789cellular_componentendoplasmic reticulum membrane
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0005925cellular_componentfocal adhesion
D0005938cellular_componentcell cortex
D0006357biological_processregulation of transcription by RNA polymerase II
D0007010biological_processcytoskeleton organization
D0007155biological_processcell adhesion
D0007160biological_processcell-matrix adhesion
D0007264biological_processsmall GTPase-mediated signal transduction
D0007266biological_processRho protein signal transduction
D0007519biological_processskeletal muscle tissue development
D0009898cellular_componentcytoplasmic side of plasma membrane
D0010812biological_processnegative regulation of cell-substrate adhesion
D0010975biological_processregulation of neuron projection development
D0016477biological_processcell migration
D0016787molecular_functionhydrolase activity
D0017022molecular_functionmyosin binding
D0019901molecular_functionprotein kinase binding
D0021762biological_processsubstantia nigra development
D0021795biological_processcerebral cortex cell migration
D0021861biological_processforebrain radial glial cell differentiation
D0030027cellular_componentlamellipodium
D0030036biological_processactin cytoskeleton organization
D0030054cellular_componentcell junction
D0030154biological_processcell differentiation
D0030334biological_processregulation of cell migration
D0030425cellular_componentdendrite
D0030496cellular_componentmidbody
D0030521biological_processandrogen receptor signaling pathway
D0030667cellular_componentsecretory granule membrane
D0031122biological_processcytoplasmic microtubule organization
D0031982cellular_componentvesicle
D0032154cellular_componentcleavage furrow
D0032467biological_processpositive regulation of cytokinesis
D0032587cellular_componentruffle membrane
D0032956biological_processregulation of actin cytoskeleton organization
D0033144biological_processnegative regulation of intracellular steroid hormone receptor signaling pathway
D0033688biological_processregulation of osteoblast proliferation
D0034329biological_processcell junction assembly
D0034446biological_processsubstrate adhesion-dependent cell spreading
D0035385biological_processRoundabout signaling pathway
D0036089biological_processcleavage furrow formation
D0038027biological_processapolipoprotein A-I-mediated signaling pathway
D0042476biological_processodontogenesis
D0042995cellular_componentcell projection
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0043149biological_processstress fiber assembly
D0043197cellular_componentdendritic spine
D0043296cellular_componentapical junction complex
D0043297biological_processapical junction assembly
D0043366biological_processbeta selection
D0043542biological_processendothelial cell migration
D0043931biological_processossification involved in bone maturation
D0044319biological_processwound healing, spreading of cells
D0045198biological_processestablishment of epithelial cell apical/basal polarity
D0045666biological_processpositive regulation of neuron differentiation
D0045792biological_processnegative regulation of cell size
D0046638biological_processpositive regulation of alpha-beta T cell differentiation
D0050919biological_processnegative chemotaxis
D0051301biological_processcell division
D0051496biological_processpositive regulation of stress fiber assembly
D0051893biological_processregulation of focal adhesion assembly
D0060071biological_processWnt signaling pathway, planar cell polarity pathway
D0060193biological_processpositive regulation of lipase activity
D0061430biological_processbone trabecula morphogenesis
D0070062cellular_componentextracellular exosome
D0070507biological_processregulation of microtubule cytoskeleton organization
D0071222biological_processcellular response to lipopolysaccharide
D0071345biological_processcellular response to cytokine stimulus
D0071526biological_processsemaphorin-plexin signaling pathway
D0071803biological_processpositive regulation of podosome assembly
D0071902biological_processpositive regulation of protein serine/threonine kinase activity
D0071944cellular_componentcell periphery
D0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
D0090307biological_processmitotic spindle assembly
D0090324biological_processnegative regulation of oxidative phosphorylation
D0097049biological_processmotor neuron apoptotic process
D0097498biological_processendothelial tube lumen extension
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0099159biological_processregulation of modification of postsynaptic structure
D0101003cellular_componentficolin-1-rich granule membrane
D1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
D1902766biological_processskeletal muscle satellite cell migration
D1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
D1903673biological_processmitotic cleavage furrow formation
D1904695biological_processpositive regulation of vascular associated smooth muscle contraction
D1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
D1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
D1990869biological_processcellular response to chemokine
D2000177biological_processregulation of neural precursor cell proliferation
D2000406biological_processpositive regulation of T cell migration
D2000672biological_processnegative regulation of motor neuron apoptotic process
F0000902biological_processcell morphogenesis
F0001764biological_processneuron migration
F0001822biological_processkidney development
F0001998biological_processangiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
F0002363biological_processalpha-beta T cell lineage commitment
F0003100biological_processregulation of systemic arterial blood pressure by endothelin
F0003189biological_processaortic valve formation
F0003924molecular_functionGTPase activity
F0003925molecular_functionG protein activity
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005768cellular_componentendosome
F0005789cellular_componentendoplasmic reticulum membrane
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005886cellular_componentplasma membrane
F0005925cellular_componentfocal adhesion
F0005938cellular_componentcell cortex
F0006357biological_processregulation of transcription by RNA polymerase II
F0007010biological_processcytoskeleton organization
F0007155biological_processcell adhesion
F0007160biological_processcell-matrix adhesion
F0007264biological_processsmall GTPase-mediated signal transduction
F0007266biological_processRho protein signal transduction
F0007519biological_processskeletal muscle tissue development
F0009898cellular_componentcytoplasmic side of plasma membrane
F0010812biological_processnegative regulation of cell-substrate adhesion
F0010975biological_processregulation of neuron projection development
F0016477biological_processcell migration
F0016787molecular_functionhydrolase activity
F0017022molecular_functionmyosin binding
F0019901molecular_functionprotein kinase binding
F0021762biological_processsubstantia nigra development
F0021795biological_processcerebral cortex cell migration
F0021861biological_processforebrain radial glial cell differentiation
F0030027cellular_componentlamellipodium
F0030036biological_processactin cytoskeleton organization
F0030054cellular_componentcell junction
F0030154biological_processcell differentiation
F0030334biological_processregulation of cell migration
F0030425cellular_componentdendrite
F0030496cellular_componentmidbody
F0030521biological_processandrogen receptor signaling pathway
F0030667cellular_componentsecretory granule membrane
F0031122biological_processcytoplasmic microtubule organization
F0031982cellular_componentvesicle
F0032154cellular_componentcleavage furrow
F0032467biological_processpositive regulation of cytokinesis
F0032587cellular_componentruffle membrane
F0032956biological_processregulation of actin cytoskeleton organization
F0033144biological_processnegative regulation of intracellular steroid hormone receptor signaling pathway
F0033688biological_processregulation of osteoblast proliferation
F0034329biological_processcell junction assembly
F0034446biological_processsubstrate adhesion-dependent cell spreading
F0035385biological_processRoundabout signaling pathway
F0036089biological_processcleavage furrow formation
F0038027biological_processapolipoprotein A-I-mediated signaling pathway
F0042476biological_processodontogenesis
F0042995cellular_componentcell projection
F0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
F0043149biological_processstress fiber assembly
F0043197cellular_componentdendritic spine
F0043296cellular_componentapical junction complex
F0043297biological_processapical junction assembly
F0043366biological_processbeta selection
F0043542biological_processendothelial cell migration
F0043931biological_processossification involved in bone maturation
F0044319biological_processwound healing, spreading of cells
F0045198biological_processestablishment of epithelial cell apical/basal polarity
F0045666biological_processpositive regulation of neuron differentiation
F0045792biological_processnegative regulation of cell size
F0046638biological_processpositive regulation of alpha-beta T cell differentiation
F0050919biological_processnegative chemotaxis
F0051301biological_processcell division
F0051496biological_processpositive regulation of stress fiber assembly
F0051893biological_processregulation of focal adhesion assembly
F0060071biological_processWnt signaling pathway, planar cell polarity pathway
F0060193biological_processpositive regulation of lipase activity
F0061430biological_processbone trabecula morphogenesis
F0070062cellular_componentextracellular exosome
F0070507biological_processregulation of microtubule cytoskeleton organization
F0071222biological_processcellular response to lipopolysaccharide
F0071345biological_processcellular response to cytokine stimulus
F0071526biological_processsemaphorin-plexin signaling pathway
F0071803biological_processpositive regulation of podosome assembly
F0071902biological_processpositive regulation of protein serine/threonine kinase activity
F0071944cellular_componentcell periphery
F0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
F0090307biological_processmitotic spindle assembly
F0090324biological_processnegative regulation of oxidative phosphorylation
F0097049biological_processmotor neuron apoptotic process
F0097498biological_processendothelial tube lumen extension
F0098794cellular_componentpostsynapse
F0098978cellular_componentglutamatergic synapse
F0099159biological_processregulation of modification of postsynaptic structure
F0101003cellular_componentficolin-1-rich granule membrane
F1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
F1902766biological_processskeletal muscle satellite cell migration
F1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
F1903673biological_processmitotic cleavage furrow formation
F1904695biological_processpositive regulation of vascular associated smooth muscle contraction
F1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
F1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
F1990869biological_processcellular response to chemokine
F2000177biological_processregulation of neural precursor cell proliferation
F2000406biological_processpositive regulation of T cell migration
F2000672biological_processnegative regulation of motor neuron apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue CL A 1501
ChainResidue
AGLN1431
APHE1434
BGLN1431
BPHE1434

site_idAC2
Number of Residues4
Detailsbinding site for residue CL A 1502
ChainResidue
ALEU1251
AASP1330
AHOH1606
AHOH1731

site_idAC3
Number of Residues26
Detailsbinding site for residue GDP F 201
ChainResidue
AHOH1651
FALA15
FCYS16
FGLY17
FLYS18
FTHR19
FCSX20
FTYR34
FLYS118
FASP120
FLEU121
FSER160
FALA161
FLYS162
FMG202
FMGF203
FHOH315
FHOH318
FHOH338
FHOH347
FHOH364
FHOH368
FHOH411
FHOH417
FHOH425
AARG1284

site_idAC4
Number of Residues6
Detailsbinding site for residue MG F 202
ChainResidue
FTHR19
FTHR37
FGDP201
FMGF203
FHOH318
FHOH338

site_idAC5
Number of Residues13
Detailsbinding site for residue MGF F 203
ChainResidue
AARG1284
FGLY14
FALA15
FLYS18
FPRO36
FTHR37
FGLY62
FGLN63
FGDP201
FMG202
FHOH308
FHOH318
FHOH338

site_idAC6
Number of Residues4
Detailsbinding site for residue CL B 1501
ChainResidue
BLEU1251
BASP1330
BHOH1624
BHOH1750

site_idAC7
Number of Residues23
Detailsbinding site for residue GDP D 201
ChainResidue
BARG1284
BHOH1620
DALA15
DCYS16
DGLY17
DLYS18
DTHR19
DCSX20
DTYR34
DLYS118
DASP120
DLEU121
DSER160
DALA161
DLYS162
DMG202
DMGF203
DHOH302
DHOH339
DHOH360
DHOH366
DHOH371
DHOH393

site_idAC8
Number of Residues6
Detailsbinding site for residue MG D 202
ChainResidue
DTHR19
DTHR37
DGDP201
DMGF203
DHOH302
DHOH339

site_idAC9
Number of Residues13
Detailsbinding site for residue MGF D 203
ChainResidue
BARG1284
DGLY14
DALA15
DLYS18
DPRO36
DTHR37
DGLY62
DGLN63
DGDP201
DMG202
DHOH301
DHOH302
DHOH339

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:10748207, ECO:0000269|PubMed:12777804
ChainResidueDetails
FGLY12
FASN117
DGLY12
DASN117

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P62820
ChainResidueDetails
FPHE30
FASP59
FSER160
DPHE30
DASP59
DSER160

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538
ChainResidueDetails
FTYR34
DTYR34

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
ChainResidueDetails
FTHR37
DTHR37

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: (Microbial infection) ADP-ribosylasparagine; by botulinum toxin => ECO:0000305|PubMed:1328215
ChainResidueDetails
FASN41
DASN41

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: 5-glutamyl serotonin => ECO:0000250|UniProtKB:Q9QUI0
ChainResidueDetails
FGLN63
DGLN63

site_idSWS_FT_FI7
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
ChainResidueDetails
FTYR34
DTYR34

site_idSWS_FT_FI8
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
ChainResidueDetails
FTHR37
DTHR37

site_idSWS_FT_FI9
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23871831
ChainResidueDetails
FLYS135
DLYS135

223166

PDB entries from 2024-07-31

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