5IR4

Crystal structure of wild-type bacterial lipoxygenase from Pseudomonas aeruginosa PA-LOX with space group C2221 at 1.48 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
A	0034440	biological_process	lipid oxidation
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue FE2 A 701

Chain	Residue
A	HIS377
A	HIS382
A	HIS555
A	ASN559
A	ILE685
A	HOH815

---

site_id	AC2
Number of Residues	21
Details	binding site for residue ZPE A 702

Chain	Residue
A	THR109
A	LEU182
A	VAL185
A	ASP190
A	LEU193
A	GLU373
A	HIS382
A	PHE415
A	ILE416
A	GLY419
A	ALA420
A	LEU424
A	ASN607
A	TYR609
A	ILE685
A	HOH871
A	HOH897
A	HOH1148
A	SER22
A	ILE23
A	TRP105

---

site_id	AC3
Number of Residues	7
Details	binding site for residue GOL A 703

Chain	Residue
A	PHE24
A	LEU28
A	ALA33
A	ARG37
A	LEU100
A	HOH825
A	HOH857

---

site_id	AC4
Number of Residues	3
Details	binding site for residue GOL A 704

Chain	Residue
A	ARG67
A	GLU514
A	HOH1243

---

site_id	AC5
Number of Residues	10
Details	binding site for residue GOL A 705

Chain	Residue
A	THR339
A	HIS340
A	PRO341
A	PRO579
A	ALA580
A	ASP582
A	GLY643
A	GLU647
A	HOH943
A	HOH1113

---

site_id	AC6
Number of Residues	8
Details	binding site for residue GOL A 706

Chain	Residue
A	PHE228
A	ARG229
A	GLN358
A	LYS361
A	THR362
A	TRP592
A	HOH921
A	HOH990

---

site_id	AC7
Number of Residues	13
Details	binding site for residue GOL A 707

Chain	Residue
A	GLN56
A	ASP58
A	ASN59
A	LYS63
A	LYS302
A	ASP432
A	PRO438
A	ILE439
A	GLN440
A	CL710
A	HOH811
A	HOH855
A	HOH900

---

site_id	AC8
Number of Residues	7
Details	binding site for residue GOL A 708

Chain	Residue
A	GLU99
A	CYS389
A	GLN393
A	ALA407
A	PHE410
A	GLU411
A	HOH843

---

site_id	AC9
Number of Residues	6
Details	binding site for residue GOL A 709

Chain	Residue
A	LYS87
A	GLY88
A	ALA444
A	GLY447
A	LEU451
A	HOH1275

---

site_id	AD1
Number of Residues	4
Details	binding site for residue CL A 710

Chain	Residue
A	LYS63
A	LYS302
A	LEU303
A	GOL707

---

site_id	AD2
Number of Residues	6
Details	binding site for residue MG A 711

Chain	Residue
A	GLU133
A	GLU133
A	HOH978
A	HOH978
A	HOH1251
A	HOH1251

---

site_id	AD3
Number of Residues	6
Details	binding site for residue PEG A 712

Chain	Residue
A	GLN131
A	ILE135
A	ALA279
A	ARG281
A	ARG323
A	HOH1066

---

Functional Information from PROSITE/UniProt

site_id	PS00081
Number of Residues	11
Details	LIPOXYGENASE_2 Lipoxygenases iron-binding region signature 2. SHPLhVLLaPH

Chain	Residue	Details
A	SER399-HIS409

---

site_id	PS00711
Number of Residues	15
Details	LIPOXYGENASE_1 Lipoxygenases iron-binding region signature 1. HEmfvHlAQTHLVsE

Chain	Residue	Details
A	HIS372-GLU386

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27500637","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IR4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00726","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27500637","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IR4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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