5IPU

Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004972	molecular_function	NMDA glutamate receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0007268	biological_process	chemical synaptic transmission
A	0010043	biological_process	response to zinc ion
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0015280	molecular_function	ligand-gated sodium channel activity
A	0016020	cellular_component	membrane
A	0017146	cellular_component	NMDA selective glutamate receptor complex
A	0019722	biological_process	calcium-mediated signaling
A	0022849	molecular_function	glutamate-gated calcium ion channel activity
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035235	biological_process	ionotropic glutamate receptor signaling pathway
A	0035725	biological_process	sodium ion transmembrane transport
A	0038023	molecular_function	signaling receptor activity
A	0042391	biological_process	regulation of membrane potential
A	0043005	cellular_component	neuron projection
A	0045202	cellular_component	synapse
A	0045211	cellular_component	postsynaptic membrane
A	0046872	molecular_function	metal ion binding
A	0070588	biological_process	calcium ion transmembrane transport
A	0098839	cellular_component	postsynaptic density membrane
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
B	0038023	molecular_function	signaling receptor activity
C	0004972	molecular_function	NMDA glutamate receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0007268	biological_process	chemical synaptic transmission
C	0010043	biological_process	response to zinc ion
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0015280	molecular_function	ligand-gated sodium channel activity
C	0016020	cellular_component	membrane
C	0017146	cellular_component	NMDA selective glutamate receptor complex
C	0019722	biological_process	calcium-mediated signaling
C	0022849	molecular_function	glutamate-gated calcium ion channel activity
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035235	biological_process	ionotropic glutamate receptor signaling pathway
C	0035725	biological_process	sodium ion transmembrane transport
C	0038023	molecular_function	signaling receptor activity
C	0042391	biological_process	regulation of membrane potential
C	0043005	cellular_component	neuron projection
C	0045202	cellular_component	synapse
C	0045211	cellular_component	postsynaptic membrane
C	0046872	molecular_function	metal ion binding
C	0070588	biological_process	calcium ion transmembrane transport
C	0098839	cellular_component	postsynaptic density membrane
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
D	0038023	molecular_function	signaling receptor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1408
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:25008524

Chain	Residue	Details
B	GLN25-MET554
B	ASP644-PHE819
D	GLN25-MET554
D	ASP644-PHE819
C	PHE629-LEU645
C	ALA811-ALA831

---

site_id	SWS_FT_FI2
Number of Residues	66
Details	TRANSMEM: Helical => ECO:0000269|PubMed:25008524

Chain	Residue	Details
B	MET555-PHE573
B	SER628-VAL643
D	MET555-PHE573
D	SER628-VAL643

---

site_id	SWS_FT_FI3
Number of Residues	64
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:25008524

Chain	Residue	Details
B	SER574-SER600
B	PHE621-ALA627
D	SER574-SER600
D	PHE621-ALA627

---

site_id	SWS_FT_FI4
Number of Residues	38
Details	INTRAMEM: Discontinuously helical => ECO:0000269|PubMed:25008524

Chain	Residue	Details
B	LEU601-PHE620
D	LEU601-PHE620

---

site_id	SWS_FT_FI5
Number of Residues	38
Details	TRANSMEM: Helical => ECO:0000250|UniProtKB:Q00960

Chain	Residue	Details
A	HIS67
A	HIS94
A	ASP100
C	HIS67
C	HIS94
C	ASP100

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305|PubMed:25008524

Chain	Residue	Details
B	GLU511
D	GLU511
A	GLN686
A	ALA730
C	PRO514
C	ARG521
C	GLN686
C	ALA730

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q00960

Chain	Residue	Details
B	VAL516
B	CYS729
D	VAL516
D	CYS729

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q00959

Chain	Residue	Details
B	SER687
D	SER687

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:25008524, ECO:0000269|PubMed:28232581, ECO:0007744|PDB:4TLL, ECO:0007744|PDB:5UOW, ECO:0007744|PDB:5UP2

Chain	Residue	Details
B	ASN336
D	ASN336

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:25008524, ECO:0000269|PubMed:28232581, ECO:0007744|PDB:4TLM, ECO:0007744|PDB:5UOW, ECO:0007744|PDB:5UP2

Chain	Residue	Details
B	MET685
D	MET685

---

site_id	SWS_FT_FI11
Number of Residues	10
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498

Chain	Residue	Details
A	GLN350
C	SER769
A	ASP440
A	ASP469
A	ASN489
A	SER769
C	GLN350
C	ASP440
C	ASP469
C	ASN489

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21677647, ECO:0007744|PDB:3QEK, ECO:0007744|PDB:3QEL, ECO:0007744|PDB:3QEM

Chain	Residue	Details
A	ASP368
C	ASP368

---