Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5IK2

Caldalaklibacillus thermarum F1-ATPase (epsilon mutant)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0006754	biological_process	ATP biosynthetic process
A	0006811	biological_process	monoatomic ion transport
A	0015986	biological_process	proton motive force-driven ATP synthesis
A	0016020	cellular_component	membrane
A	0032559	molecular_function	adenyl ribonucleotide binding
A	0043531	molecular_function	ADP binding
A	0045259	cellular_component	proton-transporting ATP synthase complex
A	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
A	0046034	biological_process	ATP metabolic process
A	0046872	molecular_function	metal ion binding
A	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
A	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0000166	molecular_function	nucleotide binding
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0006754	biological_process	ATP biosynthetic process
B	0006811	biological_process	monoatomic ion transport
B	0015986	biological_process	proton motive force-driven ATP synthesis
B	0016020	cellular_component	membrane
B	0032559	molecular_function	adenyl ribonucleotide binding
B	0043531	molecular_function	ADP binding
B	0045259	cellular_component	proton-transporting ATP synthase complex
B	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
B	0046034	biological_process	ATP metabolic process
B	0046872	molecular_function	metal ion binding
B	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
B	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
C	0000166	molecular_function	nucleotide binding
C	0005524	molecular_function	ATP binding
C	0005886	cellular_component	plasma membrane
C	0006754	biological_process	ATP biosynthetic process
C	0006811	biological_process	monoatomic ion transport
C	0015986	biological_process	proton motive force-driven ATP synthesis
C	0016020	cellular_component	membrane
C	0032559	molecular_function	adenyl ribonucleotide binding
C	0043531	molecular_function	ADP binding
C	0045259	cellular_component	proton-transporting ATP synthase complex
C	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
C	0046034	biological_process	ATP metabolic process
C	0046872	molecular_function	metal ion binding
C	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
C	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
D	0000166	molecular_function	nucleotide binding
D	0005524	molecular_function	ATP binding
D	0005886	cellular_component	plasma membrane
D	0006754	biological_process	ATP biosynthetic process
D	0006811	biological_process	monoatomic ion transport
D	0015986	biological_process	proton motive force-driven ATP synthesis
D	0016020	cellular_component	membrane
D	0016887	molecular_function	ATP hydrolysis activity
D	0045259	cellular_component	proton-transporting ATP synthase complex
D	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
D	0046034	biological_process	ATP metabolic process
D	0046872	molecular_function	metal ion binding
D	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
E	0000166	molecular_function	nucleotide binding
E	0005524	molecular_function	ATP binding
E	0005886	cellular_component	plasma membrane
E	0006754	biological_process	ATP biosynthetic process
E	0006811	biological_process	monoatomic ion transport
E	0015986	biological_process	proton motive force-driven ATP synthesis
E	0016020	cellular_component	membrane
E	0016887	molecular_function	ATP hydrolysis activity
E	0045259	cellular_component	proton-transporting ATP synthase complex
E	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
E	0046034	biological_process	ATP metabolic process
E	0046872	molecular_function	metal ion binding
E	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0000166	molecular_function	nucleotide binding
F	0005524	molecular_function	ATP binding
F	0005886	cellular_component	plasma membrane
F	0006754	biological_process	ATP biosynthetic process
F	0006811	biological_process	monoatomic ion transport
F	0015986	biological_process	proton motive force-driven ATP synthesis
F	0016020	cellular_component	membrane
F	0016887	molecular_function	ATP hydrolysis activity
F	0045259	cellular_component	proton-transporting ATP synthase complex
F	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
F	0046034	biological_process	ATP metabolic process
F	0046872	molecular_function	metal ion binding
F	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	1902600	biological_process	proton transmembrane transport
G	0005524	molecular_function	ATP binding
G	0005886	cellular_component	plasma membrane
G	0006754	biological_process	ATP biosynthetic process
G	0006811	biological_process	monoatomic ion transport
G	0015986	biological_process	proton motive force-driven ATP synthesis
G	0016020	cellular_component	membrane
G	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
G	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
G	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
G	1902600	biological_process	proton transmembrane transport
H	0000166	molecular_function	nucleotide binding
H	0005524	molecular_function	ATP binding
H	0005886	cellular_component	plasma membrane
H	0006754	biological_process	ATP biosynthetic process
H	0006811	biological_process	monoatomic ion transport
H	0015986	biological_process	proton motive force-driven ATP synthesis
H	0016020	cellular_component	membrane
H	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
H	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
H	1902600	biological_process	proton transmembrane transport
I	0000166	molecular_function	nucleotide binding
I	0005524	molecular_function	ATP binding
I	0005886	cellular_component	plasma membrane
I	0006754	biological_process	ATP biosynthetic process
I	0006811	biological_process	monoatomic ion transport
I	0015986	biological_process	proton motive force-driven ATP synthesis
I	0016020	cellular_component	membrane
I	0032559	molecular_function	adenyl ribonucleotide binding
I	0043531	molecular_function	ADP binding
I	0045259	cellular_component	proton-transporting ATP synthase complex
I	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
I	0046034	biological_process	ATP metabolic process
I	0046872	molecular_function	metal ion binding
I	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
I	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
I	1902600	biological_process	proton transmembrane transport
J	0000166	molecular_function	nucleotide binding
J	0005524	molecular_function	ATP binding
J	0005886	cellular_component	plasma membrane
J	0006754	biological_process	ATP biosynthetic process
J	0006811	biological_process	monoatomic ion transport
J	0015986	biological_process	proton motive force-driven ATP synthesis
J	0016020	cellular_component	membrane
J	0032559	molecular_function	adenyl ribonucleotide binding
J	0043531	molecular_function	ADP binding
J	0045259	cellular_component	proton-transporting ATP synthase complex
J	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
J	0046034	biological_process	ATP metabolic process
J	0046872	molecular_function	metal ion binding
J	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
J	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
J	1902600	biological_process	proton transmembrane transport
K	0000166	molecular_function	nucleotide binding
K	0005524	molecular_function	ATP binding
K	0005886	cellular_component	plasma membrane
K	0006754	biological_process	ATP biosynthetic process
K	0006811	biological_process	monoatomic ion transport
K	0015986	biological_process	proton motive force-driven ATP synthesis
K	0016020	cellular_component	membrane
K	0032559	molecular_function	adenyl ribonucleotide binding
K	0043531	molecular_function	ADP binding
K	0045259	cellular_component	proton-transporting ATP synthase complex
K	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
K	0046034	biological_process	ATP metabolic process
K	0046872	molecular_function	metal ion binding
K	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
K	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
K	1902600	biological_process	proton transmembrane transport
L	0000166	molecular_function	nucleotide binding
L	0005524	molecular_function	ATP binding
L	0005886	cellular_component	plasma membrane
L	0006754	biological_process	ATP biosynthetic process
L	0006811	biological_process	monoatomic ion transport
L	0015986	biological_process	proton motive force-driven ATP synthesis
L	0016020	cellular_component	membrane
L	0016887	molecular_function	ATP hydrolysis activity
L	0045259	cellular_component	proton-transporting ATP synthase complex
L	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
L	0046034	biological_process	ATP metabolic process
L	0046872	molecular_function	metal ion binding
L	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
L	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
L	1902600	biological_process	proton transmembrane transport
M	0000166	molecular_function	nucleotide binding
M	0005524	molecular_function	ATP binding
M	0005886	cellular_component	plasma membrane
M	0006754	biological_process	ATP biosynthetic process
M	0006811	biological_process	monoatomic ion transport
M	0015986	biological_process	proton motive force-driven ATP synthesis
M	0016020	cellular_component	membrane
M	0016887	molecular_function	ATP hydrolysis activity
M	0045259	cellular_component	proton-transporting ATP synthase complex
M	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
M	0046034	biological_process	ATP metabolic process
M	0046872	molecular_function	metal ion binding
M	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
M	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
M	1902600	biological_process	proton transmembrane transport
N	0000166	molecular_function	nucleotide binding
N	0005524	molecular_function	ATP binding
N	0005886	cellular_component	plasma membrane
N	0006754	biological_process	ATP biosynthetic process
N	0006811	biological_process	monoatomic ion transport
N	0015986	biological_process	proton motive force-driven ATP synthesis
N	0016020	cellular_component	membrane
N	0016887	molecular_function	ATP hydrolysis activity
N	0045259	cellular_component	proton-transporting ATP synthase complex
N	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
N	0046034	biological_process	ATP metabolic process
N	0046872	molecular_function	metal ion binding
N	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
N	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
N	1902600	biological_process	proton transmembrane transport
O	0005524	molecular_function	ATP binding
O	0005886	cellular_component	plasma membrane
O	0006754	biological_process	ATP biosynthetic process
O	0006811	biological_process	monoatomic ion transport
O	0015986	biological_process	proton motive force-driven ATP synthesis
O	0016020	cellular_component	membrane
O	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
O	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
O	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
O	1902600	biological_process	proton transmembrane transport
P	0000166	molecular_function	nucleotide binding
P	0005524	molecular_function	ATP binding
P	0005886	cellular_component	plasma membrane
P	0006754	biological_process	ATP biosynthetic process
P	0006811	biological_process	monoatomic ion transport
P	0015986	biological_process	proton motive force-driven ATP synthesis
P	0016020	cellular_component	membrane
P	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
P	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
P	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue ADP A 600

Chain	Residue
A	GLN172
A	GLU424
A	MG601
A	HOH701
A	HOH703
A	HOH704
A	THR173
A	GLY174
A	LYS175
A	THR176
A	THR177
A	PHE349
A	ARG354
A	GLN422

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 601

Chain	Residue
A	THR176
A	ADP600
A	HOH701
A	HOH702
A	HOH703
A	HOH704

site_id	AC3
Number of Residues	8
Details	binding site for residue GOL A 602

Chain	Residue
A	GLY282
A	ARG283
A	TYR286
A	PRO287
A	GLY288
A	TYR329
E	SER255
E	GOL602

site_id	AC4
Number of Residues	15
Details	binding site for residue ADP B 600

Chain	Residue
B	GLN172
B	THR173
B	GLY174
B	LYS175
B	THR176
B	THR177
B	PHE349
B	ARG354
B	GLN422
B	GLU424
B	MG601
B	HOH701
B	HOH703
B	HOH704
B	HOH878

site_id	AC5
Number of Residues	6
Details	binding site for residue MG B 601

Chain	Residue
B	THR176
B	ADP600
B	HOH701
B	HOH702
B	HOH703
B	HOH704

site_id	AC6
Number of Residues	6
Details	binding site for residue GOL B 602

Chain	Residue
B	VAL353
B	VAL357
B	VAL359
B	ARG390
B	VAL417
B	HOH808

site_id	AC7
Number of Residues	13
Details	binding site for residue ADP C 600

Chain	Residue
C	GLN172
C	THR173
C	GLY174
C	LYS175
C	THR176
C	THR177
C	PHE349
C	ARG354
C	GLN422
C	GLU424
C	MG601
C	HOH823
F	TYR357

site_id	AC8
Number of Residues	2
Details	binding site for residue MG C 601

Chain	Residue
C	THR176
C	ADP600

site_id	AC9
Number of Residues	6
Details	binding site for residue GOL C 602

Chain	Residue
C	MET156
C	VAL357
C	ARG390
C	VAL417
C	HOH804
C	HOH815

site_id	AD1
Number of Residues	20
Details	binding site for residue ADP D 600

Chain	Residue
C	VAL363
C	SER364
C	ARG365
C	HOH827
D	GLY152
D	GLY154
D	VAL155
D	GLY156
D	LYS157
D	THR158
D	VAL159
D	TYR334
D	PHE407
D	PHE413
D	THR414
D	MG601
D	HOH811
D	HOH849
D	HOH850
D	HOH855

site_id	AD2
Number of Residues	2
Details	binding site for residue MG D 601

Chain	Residue
D	THR158
D	ADP600

site_id	AD3
Number of Residues	13
Details	binding site for residue ADP E 600

Chain	Residue
E	GLY154
E	VAL155
E	GLY156
E	LYS157
E	THR158
E	VAL159
E	TYR334
E	ALA410
E	PHE413
E	THR414
E	HOH847
E	HOH868
E	GLY152

site_id	AD4
Number of Residues	6
Details	binding site for residue PO4 E 601

Chain	Residue
A	ARG365
E	LYS157
E	ARG184
E	ASP245
E	ASN246
E	ARG249

site_id	AD5
Number of Residues	6
Details	binding site for residue GOL E 602

Chain	Residue
A	ARG283
A	GOL602
E	SER255
E	VAL268
E	GLY269
E	TYR270

site_id	AD6
Number of Residues	7
Details	binding site for residue GOL E 603

Chain	Residue
B	PRO78
B	TYR79
B	THR80
B	PRO231
E	TYR27
E	GLN280
E	HOH811

site_id	AD7
Number of Residues	4
Details	binding site for residue GOL E 604

Chain	Residue
E	HIS112
E	ARG113
E	GLN280
E	HOH801

site_id	AD8
Number of Residues	16
Details	binding site for residue ADP F 600

Chain	Residue
F	GLY152
F	GLY154
F	VAL155
F	GLY156
F	LYS157
F	THR158
F	VAL159
F	TYR334
F	PHE407
F	ALA410
F	MG601
F	HOH819
F	HOH823
F	HOH837
F	HOH852
F	HOH861

site_id	AD9
Number of Residues	2
Details	binding site for residue MG F 601

Chain	Residue
F	THR158
F	ADP600

site_id	AE1
Number of Residues	7
Details	binding site for residue GOL F 602

Chain	Residue
B	GLY282
B	ARG283
B	GLY288
F	SER255
F	VAL268
F	HOH805
F	HOH856

site_id	AE2
Number of Residues	13
Details	binding site for residue ADP I 600

Chain	Residue
I	GLN172
I	THR173
I	GLY174
I	LYS175
I	THR176
I	THR177
I	PHE349
I	ARG354
I	GLN422
I	GLU424
I	MG601
I	HOH704
L	HOH857

site_id	AE3
Number of Residues	3
Details	binding site for residue MG I 601

Chain	Residue
I	THR176
I	ADP600
I	HOH704

site_id	AE4
Number of Residues	11
Details	binding site for residue GOL I 602

Chain	Residue
I	GLY282
I	ARG283
I	TYR286
I	PRO287
I	GLY288
I	TYR329
I	HOH856
M	SER255
M	GLU256
M	ALA259
M	GOL606

site_id	AE5
Number of Residues	11
Details	binding site for residue ADP J 600

Chain	Residue
J	GLN172
J	THR173
J	GLY174
J	LYS175
J	THR176
J	THR177
J	PHE349
J	ARG354
J	GLN422
J	GLU424
J	MG601

site_id	AE6
Number of Residues	2
Details	binding site for residue MG J 601

Chain	Residue
J	THR176
J	ADP600

site_id	AE7
Number of Residues	5
Details	binding site for residue GOL J 602

Chain	Residue
J	VAL353
J	PRO355
J	VAL357
J	ARG390
J	HOH801

site_id	AE8
Number of Residues	16
Details	binding site for residue ADP K 600

Chain	Residue
K	GLN172
K	THR173
K	GLY174
K	LYS175
K	THR176
K	THR177
K	PHE349
K	ARG354
K	GLN422
K	GLU424
K	MG601
K	HOH814
K	HOH818
K	HOH830
K	HOH869
N	TYR357

site_id	AE9
Number of Residues	2
Details	binding site for residue MG K 601

Chain	Residue
K	THR176
K	ADP600

site_id	AF1
Number of Residues	6
Details	binding site for residue GOL K 602

Chain	Residue
K	MET156
K	VAL357
K	ARG390
K	VAL417
K	HOH804
K	HOH816

site_id	AF2
Number of Residues	20
Details	binding site for residue ADP L 600

Chain	Residue
K	VAL363
K	SER364
K	ARG365
L	GLY152
L	GLY154
L	VAL155
L	GLY156
L	LYS157
L	THR158
L	VAL159
L	TYR334
L	PHE407
L	ALA410
L	PHE413
L	THR414
L	MG601
L	HOH811
L	HOH812
L	HOH849
L	HOH875

site_id	AF3
Number of Residues	2
Details	binding site for residue MG L 601

Chain	Residue
L	THR158
L	ADP600

site_id	AF4
Number of Residues	13
Details	binding site for residue ADP M 600

Chain	Residue
M	GLY152
M	GLY154
M	VAL155
M	GLY156
M	LYS157
M	THR158
M	VAL159
M	TYR334
M	ALA410
M	PHE413
M	THR414
M	HOH844
M	HOH866

site_id	AF5
Number of Residues	7
Details	binding site for residue PO4 M 602

Chain	Residue
I	ARG365
M	LYS157
M	ARG184
M	ASP245
M	ASN246
M	ARG249
M	HOH887

site_id	AF6
Number of Residues	3
Details	binding site for residue GOL M 603

Chain	Residue
M	ASN91
M	GLU213
M	HOH815

site_id	AF7
Number of Residues	6
Details	binding site for residue GOL M 604

Chain	Residue
M	TYR27
M	HIS112
M	ARG113
M	GLN280
M	ARG284
M	GOL605

site_id	AF8
Number of Residues	5
Details	binding site for residue GOL M 605

Chain	Residue
J	PRO78
J	TYR79
M	TYR27
M	GLN280
M	GOL604

site_id	AF9
Number of Residues	8
Details	binding site for residue GOL M 606

Chain	Residue
I	ARG283
I	TYR329
I	GOL602
M	SER255
M	GLY269
M	TYR270
M	HOH814
M	HOH841

site_id	AG1
Number of Residues	14
Details	binding site for residue ADP N 600

Chain	Residue
N	GLY152
N	GLY154
N	VAL155
N	GLY156
N	LYS157
N	THR158
N	VAL159
N	TYR334
N	ALA410
N	MG602
N	HOH822
N	HOH868
N	HOH872
N	HOH884

site_id	AG2
Number of Residues	2
Details	binding site for residue MG N 602

Chain	Residue
N	THR158
N	ADP600

site_id	AG3
Number of Residues	6
Details	binding site for residue GOL N 603

Chain	Residue
K	LEU115
K	GLN202
K	GLU230
N	PRO116
N	GLU117
N	PHE118

site_id	AG4
Number of Residues	8
Details	binding site for residue GOL N 604

Chain	Residue
J	GLY282
J	GLY288
N	SER255
N	VAL268
N	TYR270
N	HOH801
N	HOH811
N	HOH816

Functional Information from PROSITE/UniProt

site_id	PS00153
Number of Residues	14
Details	ATPASE_GAMMA ATP synthase gamma subunit signature. ITqEiaEivaGAnA

Chain	Residue	Details
G	ILE271-ALA284

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PAVNVGISVS

Chain	Residue	Details
A	PRO355-SER364
D	PRO335-SER344

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)