5IJZ

Crystal structure of glutamate dehydrogenase(GDH) from Corynebacterium glutamicum

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004353	molecular_function	L-glutamate dehydrogenase [NAD(P)+] activity
A	0004354	molecular_function	L-glutamate dehydrogenase (NADP+) activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006520	biological_process	amino acid metabolic process
A	0006537	biological_process	obsolete glutamate biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
B	0004353	molecular_function	L-glutamate dehydrogenase [NAD(P)+] activity
B	0004354	molecular_function	L-glutamate dehydrogenase (NADP+) activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006520	biological_process	amino acid metabolic process
B	0006537	biological_process	obsolete glutamate biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
C	0004353	molecular_function	L-glutamate dehydrogenase [NAD(P)+] activity
C	0004354	molecular_function	L-glutamate dehydrogenase (NADP+) activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006520	biological_process	amino acid metabolic process
C	0006537	biological_process	obsolete glutamate biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
D	0004353	molecular_function	L-glutamate dehydrogenase [NAD(P)+] activity
D	0004354	molecular_function	L-glutamate dehydrogenase (NADP+) activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006520	biological_process	amino acid metabolic process
D	0006537	biological_process	obsolete glutamate biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
E	0004353	molecular_function	L-glutamate dehydrogenase [NAD(P)+] activity
E	0004354	molecular_function	L-glutamate dehydrogenase (NADP+) activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006520	biological_process	amino acid metabolic process
E	0006537	biological_process	obsolete glutamate biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
E	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
F	0004353	molecular_function	L-glutamate dehydrogenase [NAD(P)+] activity
F	0004354	molecular_function	L-glutamate dehydrogenase (NADP+) activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006520	biological_process	amino acid metabolic process
F	0006537	biological_process	obsolete glutamate biosynthetic process
F	0016491	molecular_function	oxidoreductase activity
F	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
G	0004353	molecular_function	L-glutamate dehydrogenase [NAD(P)+] activity
G	0004354	molecular_function	L-glutamate dehydrogenase (NADP+) activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006520	biological_process	amino acid metabolic process
G	0006537	biological_process	obsolete glutamate biosynthetic process
G	0016491	molecular_function	oxidoreductase activity
G	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
H	0004353	molecular_function	L-glutamate dehydrogenase [NAD(P)+] activity
H	0004354	molecular_function	L-glutamate dehydrogenase (NADP+) activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006520	biological_process	amino acid metabolic process
H	0006537	biological_process	obsolete glutamate biosynthetic process
H	0016491	molecular_function	oxidoreductase activity
H	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
I	0004353	molecular_function	L-glutamate dehydrogenase [NAD(P)+] activity
I	0004354	molecular_function	L-glutamate dehydrogenase (NADP+) activity
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006520	biological_process	amino acid metabolic process
I	0006537	biological_process	obsolete glutamate biosynthetic process
I	0016491	molecular_function	oxidoreductase activity
I	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
J	0004353	molecular_function	L-glutamate dehydrogenase [NAD(P)+] activity
J	0004354	molecular_function	L-glutamate dehydrogenase (NADP+) activity
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006520	biological_process	amino acid metabolic process
J	0006537	biological_process	obsolete glutamate biosynthetic process
J	0016491	molecular_function	oxidoreductase activity
J	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
K	0004353	molecular_function	L-glutamate dehydrogenase [NAD(P)+] activity
K	0004354	molecular_function	L-glutamate dehydrogenase (NADP+) activity
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006520	biological_process	amino acid metabolic process
K	0006537	biological_process	obsolete glutamate biosynthetic process
K	0016491	molecular_function	oxidoreductase activity
K	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
L	0004353	molecular_function	L-glutamate dehydrogenase [NAD(P)+] activity
L	0004354	molecular_function	L-glutamate dehydrogenase (NADP+) activity
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006520	biological_process	amino acid metabolic process
L	0006537	biological_process	obsolete glutamate biosynthetic process
L	0016491	molecular_function	oxidoreductase activity
L	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

Functional Information from PDB Data

site_id	AC1
Number of Residues	27
Details	binding site for residue NAP A 501

Chain	Residue
A	ARG96
A	ASN243
A	VAL244
A	ASP264
A	SER265
A	ARG290
A	CYS320
A	ALA321
A	THR322
A	GLY345
A	ALA346
A	LYS136
A	ASN347
A	ASN372
A	AKG502
A	HOH604
A	HOH610
A	HOH628
A	HOH645
A	HOH657
A	ASP168
A	ILE169
A	GLY170
A	ARG208
A	THR212
A	SER241
A	GLY242

---

site_id	AC2
Number of Residues	13
Details	binding site for residue AKG A 502

Chain	Residue
A	LYS92
A	GLY93
A	GLY94
A	GLN113
A	LYS116
A	LYS128
A	ALA166
A	ARG208
A	ASN347
A	VAL376
A	SER379
A	NAP501
A	HOH636

---

site_id	AC3
Number of Residues	27
Details	binding site for residue NAP B 501

Chain	Residue
B	ARG96
B	HIS98
B	LYS136
B	ASP168
B	ILE169
B	GLY170
B	ARG208
B	THR212
B	SER241
B	GLY242
B	ASN243
B	VAL244
B	ASP264
B	SER265
B	ARG290
B	CYS320
B	ALA321
B	THR322
B	GLY345
B	ALA346
B	ASN347
B	AKG502
B	HOH609
B	HOH617
B	HOH625
B	HOH634
B	HOH681

---

site_id	AC4
Number of Residues	13
Details	binding site for residue AKG B 502

Chain	Residue
B	LYS92
B	GLY93
B	GLY94
B	GLN113
B	LYS116
B	LYS128
B	ALA166
B	THR196
B	ARG208
B	ASN347
B	VAL376
B	SER379
B	NAP501

---

site_id	AC5
Number of Residues	28
Details	binding site for residue NAP C 501

Chain	Residue
C	ASN347
C	ASN372
C	AKG502
C	HOH606
C	HOH633
C	HOH643
C	HOH656
C	HOH668
C	HOH672
C	ARG96
C	LYS136
C	ASP168
C	ILE169
C	GLY170
C	ARG208
C	THR212
C	SER241
C	GLY242
C	ASN243
C	VAL244
C	ASP264
C	SER265
C	ARG290
C	CYS320
C	ALA321
C	THR322
C	GLY345
C	ALA346

---

site_id	AC6
Number of Residues	14
Details	binding site for residue AKG C 502

Chain	Residue
C	LYS92
C	GLY93
C	GLY94
C	GLN113
C	LYS116
C	LYS128
C	ALA166
C	ARG208
C	ASN347
C	GLY375
C	VAL376
C	SER379
C	NAP501
C	HOH637

---

site_id	AC7
Number of Residues	26
Details	binding site for residue NAP D 501

Chain	Residue
D	ARG96
D	LYS136
D	ASP168
D	ILE169
D	GLY170
D	ARG208
D	THR212
D	SER241
D	GLY242
D	ASN243
D	VAL244
D	ASP264
D	SER265
D	ARG290
D	CYS320
D	ALA321
D	THR322
D	GLY345
D	ALA346
D	ASN347
D	ASN372
D	AKG502
D	HOH635
D	HOH636
D	HOH637
D	HOH643

---

site_id	AC8
Number of Residues	13
Details	binding site for residue AKG D 502

Chain	Residue
D	LYS92
D	GLY93
D	GLY94
D	GLN113
D	LYS116
D	LYS128
D	ALA166
D	ASP168
D	ARG208
D	ASN347
D	VAL376
D	SER379
D	NAP501

---

site_id	AC9
Number of Residues	27
Details	binding site for residue NAP E 501

Chain	Residue
E	ARG96
E	HIS98
E	LYS136
E	ASP168
E	ILE169
E	GLY170
E	ARG208
E	THR212
E	SER241
E	GLY242
E	ASN243
E	VAL244
E	ASP264
E	SER265
E	ARG290
E	CYS320
E	ALA321
E	THR322
E	GLY345
E	ALA346
E	ASN347
E	ASN372
E	AKG502
E	HOH621
E	HOH631
E	HOH637
E	HOH653

---

site_id	AD1
Number of Residues	12
Details	binding site for residue AKG E 502

Chain	Residue
E	LYS92
E	GLY93
E	GLY94
E	GLN113
E	LYS116
E	LYS128
E	ALA166
E	ARG208
E	ASN347
E	VAL376
E	SER379
E	NAP501

---

site_id	AD2
Number of Residues	28
Details	binding site for residue NAP F 501

Chain	Residue
F	ARG96
F	HIS98
F	LYS136
F	ASP168
F	ILE169
F	GLY170
F	ARG208
F	THR212
F	SER241
F	GLY242
F	ASN243
F	VAL244
F	ASP264
F	SER265
F	ARG290
F	CYS320
F	ALA321
F	THR322
F	GLY345
F	ALA346
F	ASN347
F	AKG502
F	HOH605
F	HOH634
F	HOH641
F	HOH643
F	HOH652
F	HOH688

---

site_id	AD3
Number of Residues	13
Details	binding site for residue AKG F 502

Chain	Residue
F	LYS92
F	GLY93
F	GLY94
F	GLN113
F	LYS116
F	LYS128
F	ALA166
F	ARG208
F	ASN347
F	VAL376
F	SER379
F	NAP501
F	HOH631

---

site_id	AD4
Number of Residues	23
Details	binding site for residue NAP G 501

Chain	Residue
G	ARG96
G	LYS136
G	ASP168
G	ILE169
G	GLY170
G	ARG208
G	THR212
G	SER241
G	GLY242
G	ASN243
G	VAL244
G	ASP264
G	SER265
G	ARG290
G	CYS320
G	ALA321
G	THR322
G	GLY345
G	ALA346
G	ASN347
G	AKG502
G	HOH608
G	HOH618

---

site_id	AD5
Number of Residues	12
Details	binding site for residue AKG G 502

Chain	Residue
G	LYS92
G	GLY93
G	GLY94
G	GLN113
G	LYS116
G	LYS128
G	ALA166
G	ARG208
G	ASN347
G	VAL376
G	SER379
G	NAP501

---

site_id	AD6
Number of Residues	25
Details	binding site for residue NAP H 501

Chain	Residue
H	ARG96
H	LYS136
H	ASP168
H	ILE169
H	GLY170
H	ARG208
H	THR212
H	SER241
H	GLY242
H	ASN243
H	VAL244
H	ASP264
H	SER265
H	ARG290
H	CYS320
H	ALA321
H	GLY345
H	ALA346
H	ASN347
H	ASN372
H	AKG502
H	HOH644
H	HOH652
H	HOH670
H	HOH688

---

site_id	AD7
Number of Residues	13
Details	binding site for residue AKG H 502

Chain	Residue
H	LYS92
H	GLY93
H	GLY94
H	GLN113
H	LYS116
H	LYS128
H	ALA166
H	ARG208
H	ASN347
H	VAL376
H	SER379
H	NAP501
H	HOH641

---

site_id	AD8
Number of Residues	19
Details	binding site for residue NAP J 501

Chain	Residue
J	ARG96
J	LYS116
J	ASP168
J	ILE169
J	ARG208
J	THR212
J	SER241
J	GLY242
J	ASN243
J	VAL244
J	ASP264
J	SER265
J	ARG290
J	ALA321
J	THR322
J	GLU325
J	GLY345
J	ASN347
J	HOH635

---

site_id	AD9
Number of Residues	10
Details	binding site for residue AKG J 502

Chain	Residue
J	LYS92
J	GLY93
J	GLY94
J	GLN113
J	LYS128
J	ALA166
J	GLY167
J	ASP168
J	ARG208
J	SER379

---

Functional Information from PROSITE/UniProt

site_id	PS00074
Number of Residues	14
Details	GLFV_DEHYDROGENASE Glu / Leu / Phe / Val dehydrogenases active site. LpiGGGKgGsdfDP

Chain	Residue	Details
A	LEU122-PRO135

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10011","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	83
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Site: {"description":"Important for catalysis","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---