5IIO

Crystal structure of the DNA polymerase lambda binary complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034061	molecular_function	DNA polymerase activity
E	0003677	molecular_function	DNA binding
E	0003887	molecular_function	DNA-directed DNA polymerase activity
E	0006281	biological_process	DNA repair
E	0016779	molecular_function	nucleotidyltransferase activity
E	0034061	molecular_function	DNA polymerase activity
I	0003677	molecular_function	DNA binding
I	0003887	molecular_function	DNA-directed DNA polymerase activity
I	0006281	biological_process	DNA repair
I	0016779	molecular_function	nucleotidyltransferase activity
I	0034061	molecular_function	DNA polymerase activity
M	0003677	molecular_function	DNA binding
M	0003887	molecular_function	DNA-directed DNA polymerase activity
M	0006281	biological_process	DNA repair
M	0016779	molecular_function	nucleotidyltransferase activity
M	0034061	molecular_function	DNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue NA A 601

Chain	Residue
A	SER339
A	ILE341
A	ALA344
C	DA5
C	HOH107
C	HOH115

---

site_id	AC2
Number of Residues	6
Details	binding site for residue NA A 602

Chain	Residue
A	HOH931
D	DC3
M	LYS307
A	CYS300
A	ILE302
A	ILE305

---

site_id	AC3
Number of Residues	6
Details	binding site for residue NA E 601

Chain	Residue
E	SER339
E	ILE341
E	ALA344
G	DA5
G	HOH101
G	HOH107

---

site_id	AC4
Number of Residues	6
Details	binding site for residue NA I 601

Chain	Residue
I	SER339
I	ILE341
I	ALA344
K	DA5
K	HOH110
K	HOH113

---

site_id	AC5
Number of Residues	6
Details	binding site for residue NA M 601

Chain	Residue
M	SER339
M	ILE341
M	ALA344
M	HOH962
O	DA5
O	HOH108

---

site_id	AC6
Number of Residues	6
Details	binding site for residue NA M 602

Chain	Residue
M	CYS300
M	ILE302
M	ILE305
M	HOH948
P	DC3
P	HOH110

---

site_id	AC7
Number of Residues	13
Details	binding site for Di-peptide CYS A 543 and CYS M 543

Chain	Residue
A	VAL537
A	ARG538
A	ASN539
A	HIS541
A	GLY542
A	LYS544
A	VAL545
M	VAL537
M	ARG538
M	ASN539
M	GLY542
M	LYS544
M	VAL545

---

site_id	AC8
Number of Residues	13
Details	binding site for Di-peptide CYS A 543 and CYS M 543

Chain	Residue
A	VAL537
A	ARG538
A	ASN539
A	HIS541
A	GLY542
A	LYS544
A	VAL545
M	VAL537
M	ARG538
M	ASN539
M	GLY542
M	LYS544
M	VAL545

---

site_id	AC9
Number of Residues	14
Details	binding site for Di-nucleotide DC J 4 and 8OG J 5

Chain	Residue
I	TRP274
I	LEU277
I	TYR505
I	ARG514
I	ARG517
I	LYS521
I	HOH705
I	HOH756
J	DG3
J	DG6
J	HOH108
J	HOH109
J	HOH115
L	DG1

---

site_id	AD1
Number of Residues	12
Details	binding site for Di-nucleotide 8OG J 5 and DG J 6

Chain	Residue
I	TYR505
I	ARG514
I	ARG517
I	HOH705
I	HOH756
J	DC4
J	DT7
J	HOH112
J	HOH115
J	HOH118
K	DA5
K	DC6

---

site_id	AD2
Number of Residues	17
Details	binding site for Di-nucleotide DC N 4 and 8OG N 5

Chain	Residue
N	HOH107
N	HOH108
N	HOH117
N	HOH121
N	HOH123
P	DG1
M	TRP274
M	LEU277
M	TYR505
M	ARG514
M	ARG517
M	LYS521
M	HOH741
N	DG3
N	DG6
N	HOH101
N	HOH103

---

site_id	AD3
Number of Residues	17
Details	binding site for Di-nucleotide 8OG N 5 and DG N 6

Chain	Residue
M	TYR505
M	ARG514
M	ARG517
M	HOH741
M	HOH883
N	DC4
N	DT7
N	HOH101
N	HOH103
N	HOH107
N	HOH114
N	HOH115
N	HOH121
N	HOH123
N	HOH127
O	DA5
O	DC6

---

Functional Information from PROSITE/UniProt

site_id	PS00522
Number of Residues	20
Details	DNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP

Chain	Residue	Details
A	GLY416-PRO435

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	224
Details	Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"14992725","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Region: {"description":"Involved in primer binding","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Schiff-base intermediate with DNA","evidences":[{"source":"PubMed","id":"11457865","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17475573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PFQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17475573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PFO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PFQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---