5IIM

Crystal structure of the pre-catalytic ternary extension complex of DNA polymerase lambda with an 8-oxo-dG:dA base-pair

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034061	molecular_function	DNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	binding site for residue DUP A 601

Chain	Residue
A	ARG386
A	THR507
A	GLY508
A	ASN513
A	NA602
A	HOH763
A	HOH768
A	HOH770
A	HOH778
A	HOH786
A	HOH823
A	GLY416
A	HOH824
P	DA6
P	HOH111
T	DA5
A	SER417
A	ARG420
A	GLY426
A	ASP427
A	ASP429
A	TYR505
A	PHE506

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site_id	AC2
Number of Residues	4
Details	binding site for residue NA A 602

Chain	Residue
A	ASP427
A	ASP429
A	DUP601
A	HOH763

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site_id	AC3
Number of Residues	6
Details	binding site for residue NA A 603

Chain	Residue
A	SER339
A	ILE341
A	ALA344
P	DA5
P	HOH104
P	HOH127

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Functional Information from PROSITE/UniProt

site_id	PS00522
Number of Residues	20
Details	DNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP

Chain	Residue	Details
A	GLY416-PRO435

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Schiff-base intermediate with DNA => ECO:0000269|PubMed:11457865

Chain	Residue	Details
A	LYS312

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ

Chain	Residue	Details
A	ARG386
A	SER417
A	GLY426
A	ASN513

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site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ

Chain	Residue	Details
A	ASP427
A	ASP429
A	ASP490

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