5IIM
Crystal structure of the pre-catalytic ternary extension complex of DNA polymerase lambda with an 8-oxo-dG:dA base-pair
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue DUP A 601 |
| Chain | Residue |
| A | ARG386 |
| A | THR507 |
| A | GLY508 |
| A | ASN513 |
| A | NA602 |
| A | HOH763 |
| A | HOH768 |
| A | HOH770 |
| A | HOH778 |
| A | HOH786 |
| A | HOH823 |
| A | GLY416 |
| A | HOH824 |
| P | DA6 |
| P | HOH111 |
| T | DA5 |
| A | SER417 |
| A | ARG420 |
| A | GLY426 |
| A | ASP427 |
| A | ASP429 |
| A | TYR505 |
| A | PHE506 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 602 |
| Chain | Residue |
| A | ASP427 |
| A | ASP429 |
| A | DUP601 |
| A | HOH763 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 603 |
| Chain | Residue |
| A | SER339 |
| A | ILE341 |
| A | ALA344 |
| P | DA5 |
| P | HOH104 |
| P | HOH127 |
Functional Information from PROSITE/UniProt
| site_id | PS00522 |
| Number of Residues | 20 |
| Details | DNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP |
| Chain | Residue | Details |
| A | GLY416-PRO435 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 56 |
| Details | Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"14992725","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Region: {"description":"Involved in primer binding","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Schiff-base intermediate with DNA","evidences":[{"source":"PubMed","id":"11457865","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17475573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PFQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17475573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PFO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PFQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
