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5IH3

Crystal structure of mouse CARM1 in complex with SAH at 1.8 Angstroms resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0016274molecular_functionprotein-arginine N-methyltransferase activity
A0018216biological_processpeptidyl-arginine methylation
B0016274molecular_functionprotein-arginine N-methyltransferase activity
B0018216biological_processpeptidyl-arginine methylation
C0016274molecular_functionprotein-arginine N-methyltransferase activity
C0018216biological_processpeptidyl-arginine methylation
D0016274molecular_functionprotein-arginine N-methyltransferase activity
D0018216biological_processpeptidyl-arginine methylation
Functional Information from PDB Data
site_idAC1
Number of Residues23
Detailsbinding site for residue SAH A 501
ChainResidue
ATYR150
AILE198
ALEU199
AGLU215
AALA216
AGLY241
ALYS242
AVAL243
AGLU244
AMET269
ASER272
APHE151
AHOH634
AHOH656
AHOH682
AHOH708
ATYR154
AGLN160
AMET163
AARG169
AGLY193
ACYS194
AGLY195

site_idAC2
Number of Residues4
Detailsbinding site for residue EDO A 502
ChainResidue
AGLU144
AALA147
APHE151
ALYS242

site_idAC3
Number of Residues3
Detailsbinding site for residue EDO A 503
ChainResidue
AASP393
ATRP404
AHOH757

site_idAC4
Number of Residues5
Detailsbinding site for residue PEG A 504
ChainResidue
APRO317
AVAL332
AGLN424
ASER425
AHOH655

site_idAC5
Number of Residues2
Detailsbinding site for residue PEG A 505
ChainResidue
ALEU178
AHOH786

site_idAC6
Number of Residues1
Detailsbinding site for residue PEG A 506
ChainResidue
AGLU267

site_idAC7
Number of Residues3
Detailsbinding site for residue PGE A 507
ChainResidue
AGLY284
ALEU361
AGLY398

site_idAC8
Number of Residues23
Detailsbinding site for residue SAH B 501
ChainResidue
BTYR150
BPHE151
BTYR154
BGLN160
BMET163
BARG169
BGLY193
BCYS194
BILE198
BLEU199
BGLU215
BALA216
BGLY241
BLYS242
BVAL243
BGLU244
BGLU258
BMET269
BSER272
BHOH640
BHOH661
BHOH668
BHOH671

site_idAC9
Number of Residues2
Detailsbinding site for residue EDO B 502
ChainResidue
BALA147
BLYS242

site_idAD1
Number of Residues3
Detailsbinding site for residue EDO B 503
ChainResidue
BPHE375
BGLY437
BHOH637

site_idAD2
Number of Residues2
Detailsbinding site for residue EDO B 504
ChainResidue
BASP393
BTRP404

site_idAD3
Number of Residues2
Detailsbinding site for residue PEG B 505
ChainResidue
BPHE153
BGLU267

site_idAD4
Number of Residues7
Detailsbinding site for residue PE8 B 506
ChainResidue
ALYS463
BSER136
BGLU244
BGLU245
BVAL246
BGLN251
BHOH695

site_idAD5
Number of Residues2
Detailsbinding site for residue DXE B 507
ChainResidue
BASN162
BLEU413

site_idAD6
Number of Residues4
Detailsbinding site for residue DXE B 508
ChainResidue
BLYS277
BPRO282
BLEU361
BHOH825

site_idAD7
Number of Residues24
Detailsbinding site for residue SAH C 501
ChainResidue
CGLY241
CLYS242
CVAL243
CGLU244
CGLU258
CMET269
CSER272
CHOH665
CHOH675
CHOH696
CHOH701
CTYR150
CPHE151
CTYR154
CGLN160
CMET163
CARG169
CGLY193
CCYS194
CGLY195
CILE198
CLEU199
CGLU215
CALA216

site_idAD8
Number of Residues1
Detailsbinding site for residue EDO C 502
ChainResidue
CHOH734

site_idAD9
Number of Residues2
Detailsbinding site for residue EDO C 504
ChainResidue
CTRP404
CHOH739

site_idAE1
Number of Residues2
Detailsbinding site for residue PEG C 505
ChainResidue
CVAL332
CGLN424

site_idAE2
Number of Residues7
Detailsbinding site for residue PEG C 506
ChainResidue
CLYS277
CLEU280
CPRO282
CLEU361
CHOH630
CHOH663
CHOH732

site_idAE3
Number of Residues3
Detailsbinding site for residue DXE C 507
ChainResidue
BGLY461
CLEU178
CGLN205

site_idAE4
Number of Residues1
Detailsbinding site for residue DXE C 508
ChainResidue
CGLU267

site_idAE5
Number of Residues24
Detailsbinding site for residue SAH D 501
ChainResidue
DTYR150
DPHE151
DTYR154
DGLN160
DMET163
DARG169
DGLY193
DCYS194
DGLY195
DILE198
DLEU199
DGLU215
DALA216
DGLY241
DLYS242
DVAL243
DGLU244
DGLU258
DMET269
DSER272
DHOH636
DHOH647
DHOH674
DHOH685

site_idAE6
Number of Residues2
Detailsbinding site for residue EDO D 502
ChainResidue
DGLN149
DHOH768

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues24
DetailsBINDING: BINDING => ECO:0000269|PubMed:17882261
ChainResidueDetails
AGLN160
BGLU215
BGLU244
BSER272
CGLN160
CARG169
CGLY193
CGLU215
CGLU244
CSER272
DGLN160
AARG169
DARG169
DGLY193
DGLU215
DGLU244
DSER272
AGLY193
AGLU215
AGLU244
ASER272
BGLN160
BARG169
BGLY193

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:19843527
ChainResidueDetails
ASER217
BSER217
CSER217
DSER217

site_idSWS_FT_FI3
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q86X55
ChainResidueDetails
ALYS228
BLYS228
CLYS228
DLYS228

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PDB entries from 2024-11-06

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