5ICS

Crystal structure of 17beta-hydroxysteroid dehydrogenase type 14 apoenzyme.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)+] activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006004	biological_process	fucose metabolic process
A	0006629	biological_process	lipid metabolic process
A	0008202	biological_process	steroid metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0042355	biological_process	L-fucose catabolic process
A	0042802	molecular_function	identical protein binding
A	0047834	molecular_function	D-threo-aldose 1-dehydrogenase activity
C	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)+] activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006004	biological_process	fucose metabolic process
C	0006629	biological_process	lipid metabolic process
C	0008202	biological_process	steroid metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0042355	biological_process	L-fucose catabolic process
C	0042802	molecular_function	identical protein binding
C	0047834	molecular_function	D-threo-aldose 1-dehydrogenase activity
D	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)+] activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006004	biological_process	fucose metabolic process
D	0006629	biological_process	lipid metabolic process
D	0008202	biological_process	steroid metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0042355	biological_process	L-fucose catabolic process
D	0042802	molecular_function	identical protein binding
D	0047834	molecular_function	D-threo-aldose 1-dehydrogenase activity
F	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)+] activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006004	biological_process	fucose metabolic process
F	0006629	biological_process	lipid metabolic process
F	0008202	biological_process	steroid metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0042355	biological_process	L-fucose catabolic process
F	0042802	molecular_function	identical protein binding
F	0047834	molecular_function	D-threo-aldose 1-dehydrogenase activity

Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. SlvgaigqaqAvpYVATKGAVtAMTkALA

Chain	Residue	Details
A	SER141-ALA169

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10001","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27362750","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27933965","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29859505","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30836176","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5EN4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ICM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O43","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O6Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O72","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6EMM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6FFB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6G4L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GTB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6H0M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6HNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6QCK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZDE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZDI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZR6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZRA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZT2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27362750","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5O6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6QCK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZRA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZT2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PDB","id":"5EN4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ICM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O43","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O6Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O72","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6EMM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6FFB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6G4L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GTB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6H0M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6HNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6QCK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZDE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZDI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZR6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZRA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZT2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27362750","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27933965","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29859505","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30836176","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5EN4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ICM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O43","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O72","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6FFB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GTB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6H0M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6HNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6QCK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZDE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZDI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZRA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZT2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27362750","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27933965","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29859505","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30836176","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5EN4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ICM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O43","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O6Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O72","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6EMM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6FFB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6G4L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GTB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6HNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6QCK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZDE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZDI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZR6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZRA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZT2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---