Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5IAW

Novel natural FXR modulator with a unique binding mode

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0006355biological_processregulation of DNA-templated transcription
A0032052molecular_functionbile acid binding
A0038183biological_processbile acid signaling pathway
B0003677molecular_functionDNA binding
B0004879molecular_functionnuclear receptor activity
B0006355biological_processregulation of DNA-templated transcription
B0032052molecular_functionbile acid binding
B0038183biological_processbile acid signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue T73 A 501
ChainResidue
APHE284
APHE461
ALEU465
ALEU287
ATHR288
AALA291
ASER332
AMET365
AHIS447
AMET450
ATRP454

site_idAC2
Number of Residues10
Detailsbinding site for residue T73 A 502
ChainResidue
AMET265
APRO266
AILE269
ATHR270
AMET290
AHIS294
ASER332
AILE335
APHE336
ATYR369

site_idAC3
Number of Residues8
Detailsbinding site for residue T73 B 501
ChainResidue
BPHE284
BLEU287
BTHR288
BMET328
BMET365
BHIS447
BMET450
BTRP454

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0007744|PDB:6HL1
ChainResidueDetails
AARG331
ATYR361
ATYR369
AHIS447
BARG331
BTYR361
BTYR369
BHIS447

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by PKC/PRKCZ => ECO:0000305|PubMed:18668687
ChainResidueDetails
ATHR442
BTHR442

site_idSWS_FT_FI3
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000305|PubMed:23546875
ChainResidueDetails
ALYS275
BLYS275

218853

PDB entries from 2024-04-24

PDB statisticsPDBj update infoContact PDBjnumon