5I6C
The structure of the eukaryotic purine/H+ symporter, UapA, in complex with Xanthine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000324 | cellular_component | fungal-type vacuole |
| A | 0002060 | molecular_function | purine nucleobase binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0015143 | molecular_function | urate transmembrane transporter activity |
| A | 0015747 | biological_process | urate transport |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0034423 | cellular_component | autophagosome lumen |
| A | 0042906 | biological_process | xanthine transport |
| A | 0042907 | molecular_function | xanthine transmembrane transporter activity |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0071702 | biological_process | organic substance transport |
| B | 0000324 | cellular_component | fungal-type vacuole |
| B | 0002060 | molecular_function | purine nucleobase binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0010008 | cellular_component | endosome membrane |
| B | 0015143 | molecular_function | urate transmembrane transporter activity |
| B | 0015747 | biological_process | urate transport |
| B | 0016020 | cellular_component | membrane |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0034423 | cellular_component | autophagosome lumen |
| B | 0042906 | biological_process | xanthine transport |
| B | 0042907 | molecular_function | xanthine transmembrane transporter activity |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0071702 | biological_process | organic substance transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue XAN A 1001 |
| Chain | Residue |
| A | GLY93 |
| A | LMT1003 |
| A | VAL153 |
| A | SER154 |
| A | PHE155 |
| A | GLU356 |
| A | THR404 |
| A | PHE406 |
| A | ALA407 |
| A | GLN408 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue LMT A 1002 |
| Chain | Residue |
| A | THR223 |
| A | VAL227 |
| A | ALA348 |
| A | ILE352 |
| A | CYS355 |
| A | ASP360 |
| A | ALA363 |
| A | ALA407 |
| A | LYS473 |
| A | ALA529 |
| A | LMT1003 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue LMT A 1003 |
| Chain | Residue |
| A | ALA89 |
| A | SER295 |
| A | VAL298 |
| A | GLU356 |
| A | GLN408 |
| A | LEU459 |
| A | SER462 |
| A | SER466 |
| A | XAN1001 |
| A | LMT1002 |
| B | ARG478 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue XAN B 1001 |
| Chain | Residue |
| B | VAL153 |
| B | SER154 |
| B | PHE155 |
| B | GLU356 |
| B | THR405 |
| B | PHE406 |
| B | ALA407 |
| B | GLN408 |
| B | LMT1003 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | binding site for residue LMT B 1002 |
| Chain | Residue |
| B | THR223 |
| B | VAL227 |
| B | ALA348 |
| B | ILE352 |
| B | CYS355 |
| B | ALA407 |
| B | SER466 |
| B | ILE470 |
| B | LYS473 |
| B | ALA529 |
| B | LMT1003 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | binding site for residue LMT B 1003 |
| Chain | Residue |
| A | ARG478 |
| B | ALA89 |
| B | SER295 |
| B | VAL298 |
| B | GLU356 |
| B | GLN408 |
| B | LEU459 |
| B | SER462 |
| B | SER466 |
| B | XAN1001 |
| B | LMT1002 |
Functional Information from PROSITE/UniProt
| site_id | PS01116 |
| Number of Residues | 21 |
| Details | XANTH_URACIL_PERMASE Xanthine/uracil permeases family signature. IPnSVMGGmktfLFAsVvisG |
| Chain | Residue | Details |
| A | ILE447-GLY467 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 486 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU77-PRO97 | |
| A | VAL451-VAL471 | |
| A | PHE482-GLY502 | |
| A | LEU522-MET542 | |
| B | LEU77-PRO97 | |
| B | LEU111-ILE131 | |
| B | TYR141-ALA161 | |
| B | ALA188-VAL209 | |
| B | ILE217-THR237 | |
| B | LEU264-LEU284 | |
| B | CYS296-PHE315 | |
| A | LEU111-ILE131 | |
| B | VAL338-VAL361 | |
| B | CYS427-ILE447 | |
| B | VAL451-VAL471 | |
| B | PHE482-GLY502 | |
| B | LEU522-MET542 | |
| A | TYR141-ALA161 | |
| A | ALA188-VAL209 | |
| A | ILE217-THR237 | |
| A | LEU264-LEU284 | |
| A | CYS296-PHE315 | |
| A | VAL338-VAL361 | |
| A | CYS427-ILE447 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:20002879 |
| Chain | Residue | Details |
| A | LYS572 | |
| B | LYS572 |
