5I2C

Arginine-bound CASTOR1 from Homo sapiens

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0034198	biological_process	cellular response to amino acid starvation
A	0034618	molecular_function	arginine binding
A	0042802	molecular_function	identical protein binding
A	0061700	cellular_component	GATOR2 complex
A	0140299	molecular_function	small molecule sensor activity
A	0140311	molecular_function	protein sequestering activity
A	1903577	biological_process	cellular response to L-arginine
A	1904262	biological_process	negative regulation of TORC1 signaling
A	1904263	biological_process	positive regulation of TORC1 signaling
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0034198	biological_process	cellular response to amino acid starvation
B	0034618	molecular_function	arginine binding
B	0042802	molecular_function	identical protein binding
B	0061700	cellular_component	GATOR2 complex
B	0140299	molecular_function	small molecule sensor activity
B	0140311	molecular_function	protein sequestering activity
B	1903577	biological_process	cellular response to L-arginine
B	1904262	biological_process	negative regulation of TORC1 signaling
B	1904263	biological_process	positive regulation of TORC1 signaling
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0034198	biological_process	cellular response to amino acid starvation
C	0034618	molecular_function	arginine binding
C	0042802	molecular_function	identical protein binding
C	0061700	cellular_component	GATOR2 complex
C	0140299	molecular_function	small molecule sensor activity
C	0140311	molecular_function	protein sequestering activity
C	1903577	biological_process	cellular response to L-arginine
C	1904262	biological_process	negative regulation of TORC1 signaling
C	1904263	biological_process	positive regulation of TORC1 signaling
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0034198	biological_process	cellular response to amino acid starvation
D	0034618	molecular_function	arginine binding
D	0042802	molecular_function	identical protein binding
D	0061700	cellular_component	GATOR2 complex
D	0140299	molecular_function	small molecule sensor activity
D	0140311	molecular_function	protein sequestering activity
D	1903577	biological_process	cellular response to L-arginine
D	1904262	biological_process	negative regulation of TORC1 signaling
D	1904263	biological_process	positive regulation of TORC1 signaling

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue ARG A 401

Chain	Residue
A	SER111
A	THR300
A	PHE301
A	PHE303
A	ASP304
A	HOH577
A	HOH594
A	HOH623
A	VAL112
A	LEU273
A	GLY274
A	GLU277
A	CYS278
A	GLY279
A	ILE280
A	VAL281

---

site_id	AC2
Number of Residues	9
Details	binding site for residue ACT A 402

Chain	Residue
A	LEU115
A	SER116
A	THR117
A	ALA229
A	SER231
A	SER238
A	VAL240
A	ILE298
A	HOH513

---

site_id	AC3
Number of Residues	17
Details	binding site for residue ARG B 401

Chain	Residue
B	SER111
B	VAL112
B	LEU273
B	GLY274
B	GLU277
B	CYS278
B	GLY279
B	ILE280
B	VAL281
B	SER299
B	THR300
B	PHE301
B	PHE303
B	ASP304
B	HOH549
B	HOH552
B	HOH577

---

site_id	AC4
Number of Residues	7
Details	binding site for residue ACT B 402

Chain	Residue
B	LEU115
B	SER116
B	THR117
B	ALA229
B	SER231
B	SER238
B	ILE298

---

site_id	AC5
Number of Residues	17
Details	binding site for residue ARG C 401

Chain	Residue
C	SER111
C	VAL112
C	LEU273
C	GLY274
C	GLU277
C	CYS278
C	GLY279
C	ILE280
C	VAL281
C	SER299
C	THR300
C	PHE301
C	PHE303
C	ASP304
C	HOH566
C	HOH572
C	HOH592

---

site_id	AC6
Number of Residues	7
Details	binding site for residue ACT C 402

Chain	Residue
C	SER116
C	THR117
C	SER231
C	SER238
C	VAL240
C	ILE298
C	HOH506

---

site_id	AC7
Number of Residues	16
Details	binding site for residue ARG D 401

Chain	Residue
D	SER111
D	VAL112
D	LEU273
D	GLY274
D	GLU277
D	CYS278
D	GLY279
D	ILE280
D	VAL281
D	THR300
D	PHE301
D	PHE303
D	ASP304
D	HOH529
D	HOH540
D	HOH581

---

site_id	AC8
Number of Residues	6
Details	binding site for residue ACT D 402

Chain	Residue
D	LEU115
D	SER116
D	SER231
D	SER238
D	ILE298
D	HOH514

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:27487210, ECO:0007744|PDB:5I2C

Chain	Residue	Details
A	SER111
C	GLY274
C	ILE280
C	THR300
D	SER111
D	GLY274
D	ILE280
D	THR300
A	GLY274
A	ILE280
A	THR300
B	SER111
B	GLY274
B	ILE280
B	THR300
C	SER111

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKB/AKT1 => ECO:0000269|PubMed:33594058

Chain	Residue	Details
A	SER14
B	SER14
C	SER14
D	SER14

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