5I2C
Arginine-bound CASTOR1 from Homo sapiens
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0034198 | biological_process | cellular response to amino acid starvation |
| A | 0034618 | molecular_function | arginine binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0061700 | cellular_component | GATOR2 complex |
| A | 0140299 | molecular_function | molecular sensor activity |
| A | 0140311 | molecular_function | protein sequestering activity |
| A | 1903577 | biological_process | cellular response to L-arginine |
| A | 1904262 | biological_process | negative regulation of TORC1 signaling |
| A | 1904263 | biological_process | positive regulation of TORC1 signaling |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0034198 | biological_process | cellular response to amino acid starvation |
| B | 0034618 | molecular_function | arginine binding |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0061700 | cellular_component | GATOR2 complex |
| B | 0140299 | molecular_function | molecular sensor activity |
| B | 0140311 | molecular_function | protein sequestering activity |
| B | 1903577 | biological_process | cellular response to L-arginine |
| B | 1904262 | biological_process | negative regulation of TORC1 signaling |
| B | 1904263 | biological_process | positive regulation of TORC1 signaling |
| C | 0005515 | molecular_function | protein binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0034198 | biological_process | cellular response to amino acid starvation |
| C | 0034618 | molecular_function | arginine binding |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0061700 | cellular_component | GATOR2 complex |
| C | 0140299 | molecular_function | molecular sensor activity |
| C | 0140311 | molecular_function | protein sequestering activity |
| C | 1903577 | biological_process | cellular response to L-arginine |
| C | 1904262 | biological_process | negative regulation of TORC1 signaling |
| C | 1904263 | biological_process | positive regulation of TORC1 signaling |
| D | 0005515 | molecular_function | protein binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0034198 | biological_process | cellular response to amino acid starvation |
| D | 0034618 | molecular_function | arginine binding |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0061700 | cellular_component | GATOR2 complex |
| D | 0140299 | molecular_function | molecular sensor activity |
| D | 0140311 | molecular_function | protein sequestering activity |
| D | 1903577 | biological_process | cellular response to L-arginine |
| D | 1904262 | biological_process | negative regulation of TORC1 signaling |
| D | 1904263 | biological_process | positive regulation of TORC1 signaling |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue ARG A 401 |
| Chain | Residue |
| A | SER111 |
| A | THR300 |
| A | PHE301 |
| A | PHE303 |
| A | ASP304 |
| A | HOH577 |
| A | HOH594 |
| A | HOH623 |
| A | VAL112 |
| A | LEU273 |
| A | GLY274 |
| A | GLU277 |
| A | CYS278 |
| A | GLY279 |
| A | ILE280 |
| A | VAL281 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue ACT A 402 |
| Chain | Residue |
| A | LEU115 |
| A | SER116 |
| A | THR117 |
| A | ALA229 |
| A | SER231 |
| A | SER238 |
| A | VAL240 |
| A | ILE298 |
| A | HOH513 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue ARG B 401 |
| Chain | Residue |
| B | SER111 |
| B | VAL112 |
| B | LEU273 |
| B | GLY274 |
| B | GLU277 |
| B | CYS278 |
| B | GLY279 |
| B | ILE280 |
| B | VAL281 |
| B | SER299 |
| B | THR300 |
| B | PHE301 |
| B | PHE303 |
| B | ASP304 |
| B | HOH549 |
| B | HOH552 |
| B | HOH577 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue ACT B 402 |
| Chain | Residue |
| B | LEU115 |
| B | SER116 |
| B | THR117 |
| B | ALA229 |
| B | SER231 |
| B | SER238 |
| B | ILE298 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | binding site for residue ARG C 401 |
| Chain | Residue |
| C | SER111 |
| C | VAL112 |
| C | LEU273 |
| C | GLY274 |
| C | GLU277 |
| C | CYS278 |
| C | GLY279 |
| C | ILE280 |
| C | VAL281 |
| C | SER299 |
| C | THR300 |
| C | PHE301 |
| C | PHE303 |
| C | ASP304 |
| C | HOH566 |
| C | HOH572 |
| C | HOH592 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue ACT C 402 |
| Chain | Residue |
| C | SER116 |
| C | THR117 |
| C | SER231 |
| C | SER238 |
| C | VAL240 |
| C | ILE298 |
| C | HOH506 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | binding site for residue ARG D 401 |
| Chain | Residue |
| D | SER111 |
| D | VAL112 |
| D | LEU273 |
| D | GLY274 |
| D | GLU277 |
| D | CYS278 |
| D | GLY279 |
| D | ILE280 |
| D | VAL281 |
| D | THR300 |
| D | PHE301 |
| D | PHE303 |
| D | ASP304 |
| D | HOH529 |
| D | HOH540 |
| D | HOH581 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue ACT D 402 |
| Chain | Residue |
| D | LEU115 |
| D | SER116 |
| D | SER231 |
| D | SER238 |
| D | ILE298 |
| D | HOH514 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 28 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27487210","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5I2C","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by PKB/AKT1","evidences":[{"source":"PubMed","id":"33594058","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 122 |
| Details | Domain: {"description":"ACT 2"} |
| Chain | Residue | Details |
