5HXH
Structural mechanisms of extracellular ion exchange and induced binding-site occlusion in the sodium-calcium exchanger NCX_Mj soaked with zero Na+ and Ca2+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006874 | biological_process | intracellular calcium ion homeostasis |
| A | 0008273 | molecular_function | calcium, potassium:sodium antiporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 0005262 | molecular_function | calcium channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006874 | biological_process | intracellular calcium ion homeostasis |
| B | 0008273 | molecular_function | calcium, potassium:sodium antiporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0035725 | biological_process | sodium ion transmembrane transport |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 401 |
| Chain | Residue |
| A | ILE118 |
| A | ASP121 |
| A | GLY122 |
| A | ASP127 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue 1PE A 402 |
| Chain | Residue |
| A | TYR17 |
| A | ASP21 |
| A | MET215 |
| A | LYS222 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue MYS A 403 |
| Chain | Residue |
| A | LEU270 |
| A | PHE274 |
| A | LEU287 |
| A | ILE170 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue MYS A 405 |
| Chain | Residue |
| A | TRP283 |
| A | LEU287 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue CA B 401 |
| Chain | Residue |
| B | ILE118 |
| B | ASP121 |
| B | GLY122 |
| B | ASP127 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue 1PE B 402 |
| Chain | Residue |
| B | TYR8 |
| B | GLU180 |
| B | LEU181 |
| B | ASP184 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue 1PE B 403 |
| Chain | Residue |
| B | LEU4 |
| B | TYR8 |
| B | LYS188 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue 1PE B 404 |
| Chain | Residue |
| B | TYR17 |
| B | ASP21 |
| B | MET215 |
| B | LEU218 |
| B | ALA219 |
| B | LYS222 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue OLC B 405 |
| Chain | Residue |
| B | LYS103 |
| B | VAL107 |
| B | PHE111 |
| B | LEU134 |
| B | TRP141 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue OLC B 406 |
| Chain | Residue |
| A | VAL107 |
| A | ILE137 |
| A | TRP141 |
| B | ILE195 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue MYS B 407 |
| Chain | Residue |
| B | TRP22 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 340 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
