5HXF
Crystal structure of 3C protease from a mild Human enterovirus 71 in complex with rupintrivir
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019028 | cellular_component | viral capsid |
| A | 0019062 | biological_process | virion attachment to host cell |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0039618 | cellular_component | T=pseudo3 icosahedral viral capsid |
| A | 0044423 | cellular_component | virion component |
| A | 0046718 | biological_process | symbiont entry into host cell |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue AG7 A 201 |
| Chain | Residue |
| A | GLN23 |
| A | LYS131 |
| A | THR143 |
| A | LYS144 |
| A | ALA145 |
| A | GLY146 |
| A | CYS148 |
| A | HIS162 |
| A | ILE163 |
| A | GLY164 |
| A | GLY165 |
| A | PHE26 |
| A | ASN166 |
| A | PHE171 |
| A | SO4203 |
| A | HOH321 |
| A | HOH361 |
| A | HIS41 |
| A | GLU72 |
| A | TYR123 |
| A | LEU126 |
| A | ASN127 |
| A | LEU128 |
| A | SER129 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 202 |
| Chain | Residue |
| A | ASN56 |
| A | LYS176 |
| A | SER178 |
| A | HOH376 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 203 |
| Chain | Residue |
| A | ARG40 |
| A | HIS41 |
| A | GLN43 |
| A | LYS131 |
| A | AG7201 |
| A | HOH321 |
