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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5HVK

Crystal structure of LIMK1 mutant D460N in complex with full-length cofilin-1

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0000281biological_processmitotic cytokinesis
B0001755biological_processneural crest cell migration
B0001842biological_processneural fold formation
B0003779molecular_functionactin binding
B0005102molecular_functionsignaling receptor binding
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005911cellular_componentcell-cell junction
B0005925cellular_componentfocal adhesion
B0006606biological_processprotein import into nucleus
B0007010biological_processcytoskeleton organization
B0007015biological_processactin filament organization
B0007162biological_processnegative regulation of cell adhesion
B0007266biological_processRho protein signal transduction
B0008154biological_processactin polymerization or depolymerization
B0009615biological_processresponse to virus
B0010592biological_processpositive regulation of lamellipodium assembly
B0010593biological_processnegative regulation of lamellipodium assembly
B0014823biological_processresponse to activity
B0015629cellular_componentactin cytoskeleton
B0016020cellular_componentmembrane
B0016363cellular_componentnuclear matrix
B0019903molecular_functionprotein phosphatase binding
B0021766biological_processhippocampus development
B0022604biological_processregulation of cell morphogenesis
B0030010biological_processestablishment of cell polarity
B0030027cellular_componentlamellipodium
B0030030biological_processcell projection organization
B0030036biological_processactin cytoskeleton organization
B0030042biological_processactin filament depolymerization
B0030043biological_processactin filament fragmentation
B0030175cellular_componentfilopodium
B0030307biological_processpositive regulation of cell growth
B0030424cellular_componentaxon
B0030426cellular_componentgrowth cone
B0030835biological_processnegative regulation of actin filament depolymerization
B0030836biological_processpositive regulation of actin filament depolymerization
B0030864cellular_componentcortical actin cytoskeleton
B0031252cellular_componentcell leading edge
B0031258cellular_componentlamellipodium membrane
B0031915biological_processpositive regulation of synaptic plasticity
B0031966cellular_componentmitochondrial membrane
B0031982cellular_componentvesicle
B0032232biological_processnegative regulation of actin filament bundle assembly
B0032587cellular_componentruffle membrane
B0040019biological_processpositive regulation of embryonic development
B0043025cellular_componentneuronal cell body
B0043066biological_processnegative regulation of apoptotic process
B0043197cellular_componentdendritic spine
B0043200biological_processresponse to amino acid
B0044794biological_processhost-mediated activation of viral process
B0045792biological_processnegative regulation of cell size
B0045862biological_processpositive regulation of proteolysis
B0048870biological_processcell motility
B0050804biological_processmodulation of chemical synaptic transmission
B0051014biological_processactin filament severing
B0051015molecular_functionactin filament binding
B0051293biological_processestablishment of spindle localization
B0051511biological_processnegative regulation of unidimensional cell growth
B0051894biological_processpositive regulation of focal adhesion assembly
B0060999biological_processpositive regulation of dendritic spine development
B0061001biological_processregulation of dendritic spine morphogenesis
B0070062cellular_componentextracellular exosome
B0070301biological_processcellular response to hydrogen peroxide
B0071347biological_processcellular response to interleukin-1
B0071354biological_processcellular response to interleukin-6
B0071356biological_processcellular response to tumor necrosis factor
B0071362biological_processcellular response to ether
B0071364biological_processcellular response to epidermal growth factor stimulus
B0090732cellular_componentcofilin-actin rod
B0097060cellular_componentsynaptic membrane
B0098885biological_processmodification of postsynaptic actin cytoskeleton
B0098978cellular_componentglutamatergic synapse
B0099092cellular_componentpostsynaptic density, intracellular component
B1902936molecular_functionphosphatidylinositol bisphosphate binding
B1902951biological_processnegative regulation of dendritic spine maintenance
B1905873biological_processpositive regulation of protein localization to cell leading edge
B1905875biological_processnegative regulation of postsynaptic density organization
B1990314biological_processcellular response to insulin-like growth factor stimulus
B2000146biological_processnegative regulation of cell motility
B2000147biological_processpositive regulation of cell motility
B2000784biological_processpositive regulation of establishment of cell polarity regulating cell shape
B2000814biological_processpositive regulation of barbed-end actin filament capping
C0004672molecular_functionprotein kinase activity
C0005524molecular_functionATP binding
C0006468biological_processprotein phosphorylation
D0000281biological_processmitotic cytokinesis
D0001755biological_processneural crest cell migration
D0001842biological_processneural fold formation
D0003779molecular_functionactin binding
D0005102molecular_functionsignaling receptor binding
D0005515molecular_functionprotein binding
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005911cellular_componentcell-cell junction
D0005925cellular_componentfocal adhesion
D0006606biological_processprotein import into nucleus
D0007010biological_processcytoskeleton organization
D0007015biological_processactin filament organization
D0007162biological_processnegative regulation of cell adhesion
D0007266biological_processRho protein signal transduction
D0008154biological_processactin polymerization or depolymerization
D0009615biological_processresponse to virus
D0010592biological_processpositive regulation of lamellipodium assembly
D0010593biological_processnegative regulation of lamellipodium assembly
D0014823biological_processresponse to activity
D0015629cellular_componentactin cytoskeleton
D0016020cellular_componentmembrane
D0016363cellular_componentnuclear matrix
D0019903molecular_functionprotein phosphatase binding
D0021766biological_processhippocampus development
D0022604biological_processregulation of cell morphogenesis
D0030010biological_processestablishment of cell polarity
D0030027cellular_componentlamellipodium
D0030030biological_processcell projection organization
D0030036biological_processactin cytoskeleton organization
D0030042biological_processactin filament depolymerization
D0030043biological_processactin filament fragmentation
D0030175cellular_componentfilopodium
D0030307biological_processpositive regulation of cell growth
D0030424cellular_componentaxon
D0030426cellular_componentgrowth cone
D0030835biological_processnegative regulation of actin filament depolymerization
D0030836biological_processpositive regulation of actin filament depolymerization
D0030864cellular_componentcortical actin cytoskeleton
D0031252cellular_componentcell leading edge
D0031258cellular_componentlamellipodium membrane
D0031915biological_processpositive regulation of synaptic plasticity
D0031966cellular_componentmitochondrial membrane
D0031982cellular_componentvesicle
D0032232biological_processnegative regulation of actin filament bundle assembly
D0032587cellular_componentruffle membrane
D0040019biological_processpositive regulation of embryonic development
D0043025cellular_componentneuronal cell body
D0043066biological_processnegative regulation of apoptotic process
D0043197cellular_componentdendritic spine
D0043200biological_processresponse to amino acid
D0044794biological_processhost-mediated activation of viral process
D0045792biological_processnegative regulation of cell size
D0045862biological_processpositive regulation of proteolysis
D0048870biological_processcell motility
D0050804biological_processmodulation of chemical synaptic transmission
D0051014biological_processactin filament severing
D0051015molecular_functionactin filament binding
D0051293biological_processestablishment of spindle localization
D0051511biological_processnegative regulation of unidimensional cell growth
D0051894biological_processpositive regulation of focal adhesion assembly
D0060999biological_processpositive regulation of dendritic spine development
D0061001biological_processregulation of dendritic spine morphogenesis
D0070062cellular_componentextracellular exosome
D0070301biological_processcellular response to hydrogen peroxide
D0071347biological_processcellular response to interleukin-1
D0071354biological_processcellular response to interleukin-6
D0071356biological_processcellular response to tumor necrosis factor
D0071362biological_processcellular response to ether
D0071364biological_processcellular response to epidermal growth factor stimulus
D0090732cellular_componentcofilin-actin rod
D0097060cellular_componentsynaptic membrane
D0098885biological_processmodification of postsynaptic actin cytoskeleton
D0098978cellular_componentglutamatergic synapse
D0099092cellular_componentpostsynaptic density, intracellular component
D1902936molecular_functionphosphatidylinositol bisphosphate binding
D1902951biological_processnegative regulation of dendritic spine maintenance
D1905873biological_processpositive regulation of protein localization to cell leading edge
D1905875biological_processnegative regulation of postsynaptic density organization
D1990314biological_processcellular response to insulin-like growth factor stimulus
D2000146biological_processnegative regulation of cell motility
D2000147biological_processpositive regulation of cell motility
D2000784biological_processpositive regulation of establishment of cell polarity regulating cell shape
D2000814biological_processpositive regulation of barbed-end actin filament capping
Functional Information from PDB Data
site_idAC1
Number of Residues15
Detailsbinding site for residue ANP A 1001
ChainResidue
ALEU345
ATHR420
AASN465
ALEU467
AASP478
AMG1002
BSEP3
ACYS349
AGLY351
AVAL366
ALYS368
ALEU397
ATHR413
AGLU414
AILE416
site_idAC2
Number of Residues3
Detailsbinding site for residue MG A 1002
ChainResidue
AHIS464
AASN465
AANP1001
site_idAC3
Number of Residues14
Detailsbinding site for residue ANP C 701
ChainResidue
CLEU345
CGLY351
CVAL366
CLYS368
CLEU397
CTHR413
CGLU414
CILE416
CTHR420
CLEU467
CASP478
CMG702
DALA2
DSER3
site_idAC4
Number of Residues3
Detailsbinding site for residue MG C 702
ChainResidue
CHIS464
CASN465
CANP701
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGCFGQAIkVthretgev..........MVMK
ChainResidueDetails
ALEU345-LYS368
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues18
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine; by ROCK1 and PAK1","evidences":[{"source":"PubMed","id":"10559936","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10652353","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15660133","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23633677","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues298
DetailsDomain: {"description":"ADF-H","evidences":[{"source":"PROSITE-ProRule","id":"PRU00599","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues8
DetailsMotif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P18760","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues6
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"30550596","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"30550596","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"30550596","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"30550596","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"30550596","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2005","submissionDatabase":"UniProtKB","authors":["Quadroni M.","Bienvenut W.V."]}},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by NRK","evidences":[{"source":"PubMed","id":"12837278","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30550596","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

242842

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