5HTK

Human Heart 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase (PFKFB2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0003873	molecular_function	6-phosphofructo-2-kinase activity
A	0004331	molecular_function	fructose-2,6-bisphosphate 2-phosphatase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005654	cellular_component	nucleoplasm
A	0005829	cellular_component	cytosol
A	0006000	biological_process	fructose metabolic process
A	0006003	biological_process	fructose 2,6-bisphosphate metabolic process
A	0006007	biological_process	glucose catabolic process
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0009749	biological_process	response to glucose
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0016787	molecular_function	hydrolase activity
A	0019249	biological_process	lactate biosynthetic process
A	0019900	molecular_function	kinase binding
A	0019901	molecular_function	protein kinase binding
A	0032024	biological_process	positive regulation of insulin secretion
A	0042866	biological_process	pyruvate biosynthetic process
A	0043540	cellular_component	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
A	0046835	biological_process	carbohydrate phosphorylation
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0003873	molecular_function	6-phosphofructo-2-kinase activity
B	0004331	molecular_function	fructose-2,6-bisphosphate 2-phosphatase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005654	cellular_component	nucleoplasm
B	0005829	cellular_component	cytosol
B	0006000	biological_process	fructose metabolic process
B	0006003	biological_process	fructose 2,6-bisphosphate metabolic process
B	0006007	biological_process	glucose catabolic process
B	0006094	biological_process	gluconeogenesis
B	0006096	biological_process	glycolytic process
B	0009749	biological_process	response to glucose
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0016787	molecular_function	hydrolase activity
B	0019249	biological_process	lactate biosynthetic process
B	0019900	molecular_function	kinase binding
B	0019901	molecular_function	protein kinase binding
B	0032024	biological_process	positive regulation of insulin secretion
B	0042866	biological_process	pyruvate biosynthetic process
B	0043540	cellular_component	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
B	0046835	biological_process	carbohydrate phosphorylation

Functional Information from PROSITE/UniProt

site_id	PS00175
Number of Residues	10
Details	PG_MUTASE Phosphoglycerate mutase family phosphohistidine signature. LcRHGEsEfN

Chain	Residue	Details
A	LEU254-ASN263

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Tele-phosphohistidine intermediate","evidences":[{"source":"UniProtKB","id":"Q16875","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"Q16875","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	58
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q16875","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P07953","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"Q16875","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---