5HT2
Mouse Tdp2 reaction product (5'-phosphorylated DNA)-Mg2+ complex with 1-N6-etheno-adenine
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 401 |
| Chain | Residue |
| A | GLU162 |
| A | HOH522 |
| A | HOH551 |
| A | HOH553 |
| D | HOH116 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 401 |
| Chain | Residue |
| C | HOH117 |
| B | GLU162 |
| B | HOH526 |
| B | HOH538 |
| B | HOH557 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue EPE B 402 |
| Chain | Residue |
| B | CYS149 |
| B | TYR153 |
| B | VAL345 |
| B | GLY346 |
| B | LEU347 |
| B | GLU348 |
| B | HOH592 |
| B | HOH681 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue PEG B 403 |
| Chain | Residue |
| A | HOH621 |
| A | HOH645 |
| A | HOH819 |
| B | ILE180 |
| B | ILE181 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue MG B 404 |
| Chain | Residue |
| A | ASP288 |
| A | HOH502 |
| B | GLN340 |
| B | HOH506 |
| B | HOH661 |
| B | HOH710 |
| B | HOH765 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:23104055, ECO:0000305|PubMed:27060144 |
| Chain | Residue | Details |
| A | ASP272 | |
| B | ASP272 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23104055, ECO:0000269|PubMed:27099339, ECO:0007744|PDB:4GYZ, ECO:0007744|PDB:4GZ2, ECO:0007744|PDB:5J42 |
| Chain | Residue | Details |
| A | ASP132 | |
| B | ASP132 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23104055, ECO:0000269|PubMed:24808172, ECO:0000269|PubMed:27099339, ECO:0007744|PDB:4GYZ, ECO:0007744|PDB:4GZ1, ECO:0007744|PDB:4GZ2, ECO:0007744|PDB:4PUQ, ECO:0007744|PDB:5HT2, ECO:0007744|PDB:5INP, ECO:0007744|PDB:5J42 |
| Chain | Residue | Details |
| A | GLU162 | |
| B | GLU162 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Interaction with 5' end of substrate DNA => ECO:0000269|PubMed:23104055, ECO:0000269|PubMed:27060144 |
| Chain | Residue | Details |
| A | TYR188 | |
| B | TYR188 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | SITE: Interaction with 5' end of substrate DNA => ECO:0000269|PubMed:23104055, ECO:0000269|PubMed:24808172, ECO:0000269|PubMed:27060144 |
| Chain | Residue | Details |
| A | TRP307 | |
| A | HIS359 | |
| B | TRP307 | |
| B | HIS359 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Interaction with 5' end of substrate DNA => ECO:0000269|PubMed:23104055 |
| Chain | Residue | Details |
| A | PHE325 | |
| B | PHE325 |
