5HQN
Catalytic domain of murine Acid Sphingomyelinase (ASMase, ASM, SMPD1)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004767 | molecular_function | sphingomyelin phosphodiesterase activity |
| A | 0006685 | biological_process | sphingomyelin catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| B | 0004767 | molecular_function | sphingomyelin phosphodiesterase activity |
| B | 0006685 | biological_process | sphingomyelin catabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27435900, ECO:0007744|PDB:5FI9, ECO:0007744|PDB:5FIB, ECO:0007744|PDB:5FIC, ECO:0007744|PDB:5HQN |
| Chain | Residue | Details |
| A | ASP204 | |
| B | ASN316 | |
| B | HIS423 | |
| B | HIS455 | |
| A | HIS206 | |
| A | ASP276 | |
| A | ASN316 | |
| A | HIS423 | |
| A | HIS455 | |
| B | ASP204 | |
| B | HIS206 | |
| B | ASP276 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0007744|PDB:5FI9, ECO:0007744|PDB:5FIB, ECO:0007744|PDB:5FIC, ECO:0007744|PDB:5HQN |
| Chain | Residue | Details |
| A | HIS457 | |
| B | HIS457 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by CASP7 => ECO:0000305|PubMed:35705808 |
| Chain | Residue | Details |
| A | ASP249 | |
| B | ASP249 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P17405 |
| Chain | Residue | Details |
| A | SER506 | |
| B | SER506 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00415, ECO:0000269|PubMed:27435900, ECO:0007744|PDB:5FI9, ECO:0007744|PDB:5FIB, ECO:0007744|PDB:5HQN |
| Chain | Residue | Details |
| A | ASN173 | |
| A | ASN333 | |
| B | ASN173 | |
| B | ASN333 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00415, ECO:0000269|PubMed:27435900, ECO:0007744|PDB:5FI9, ECO:0007744|PDB:5FIB, ECO:0007744|PDB:5FIC, ECO:0007744|PDB:5HQN |
| Chain | Residue | Details |
| A | ASN393 | |
| A | ASN518 | |
| B | ASN393 | |
| B | ASN518 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00415 |
| Chain | Residue | Details |
| A | ASN611 | |
| B | ASN611 |
