5HNM

Crystal structure of vancomycin resistance D,D-pentapeptidase VanY E175A mutant from VanB-type resistance cassette in complex with Zn(II)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
C	0006508	biological_process	proteolysis
C	0008233	molecular_function	peptidase activity
D	0006508	biological_process	proteolysis
D	0008233	molecular_function	peptidase activity
E	0006508	biological_process	proteolysis
E	0008233	molecular_function	peptidase activity
F	0006508	biological_process	proteolysis
F	0008233	molecular_function	peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 301

Chain	Residue
A	HIS188
A	ASP195
A	HIS241
A	SO4302

---

site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 A 302

Chain	Residue
A	HOH447
A	ARG146
A	HIS188
A	ASP195
A	GLU238
A	ZN301

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN B 301

Chain	Residue
B	HIS188
B	ASP195
B	HIS241
B	SO4302

---

site_id	AC4
Number of Residues	10
Details	binding site for residue SO4 B 302

Chain	Residue
B	ARG146
B	TRP179
B	HIS188
B	ASP195
B	GLU238
B	TRP240
B	HIS241
B	ZN301
B	HOH402
B	HOH415

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN C 500

Chain	Residue
C	HIS188
C	ASP195
C	HIS241
C	HOH632

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN D 500

Chain	Residue
D	HIS188
D	ASP195
D	HIS241
D	HOH667

---

site_id	AC7
Number of Residues	5
Details	binding site for residue ZN E 301

Chain	Residue
E	ARG146
E	HIS188
E	ASP195
E	HIS241
E	SO4302

---

site_id	AC8
Number of Residues	10
Details	binding site for residue SO4 E 302

Chain	Residue
E	ARG146
E	TRP179
E	HIS188
E	ASP195
E	GLU238
E	TRP240
E	HIS241
E	ZN301
E	HOH401
E	HOH434

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN F 301

Chain	Residue
F	HIS188
F	ASP195
F	HIS241
F	HOH443

---

site_id	AD1
Number of Residues	2
Details	binding site for residue SO4 F 302

Chain	Residue
F	VAL106
F	HOH405

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:30016658

Chain	Residue	Details
A	GLU238
B	GLU238
C	GLU238
D	GLU238
E	GLU238
F	GLU238

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:30016658

Chain	Residue	Details
A	GLN151
D	GLN151
D	TRP179
D	SER186
E	GLN151
E	TRP179
E	SER186
F	GLN151
F	TRP179
F	SER186
A	TRP179
A	SER186
B	GLN151
B	TRP179
B	SER186
C	GLN151
C	TRP179
C	SER186

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:30016658, ECO:0007744|PDB:5HNM

Chain	Residue	Details
A	HIS188
D	HIS188
D	ASP195
D	HIS241
E	HIS188
E	ASP195
E	HIS241
F	HIS188
F	ASP195
F	HIS241
A	ASP195
A	HIS241
B	HIS188
B	ASP195
B	HIS241
C	HIS188
C	ASP195
C	HIS241

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