5HN8

Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH-1182

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004161	molecular_function	dimethylallyltranstransferase activity
A	0004337	molecular_function	(2E,6E)-farnesyl diphosphate synthase activity
A	0004659	molecular_function	prenyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0008299	biological_process	isoprenoid biosynthetic process
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
A	0045337	biological_process	farnesyl diphosphate biosynthetic process
B	0004161	molecular_function	dimethylallyltranstransferase activity
B	0004337	molecular_function	(2E,6E)-farnesyl diphosphate synthase activity
B	0004659	molecular_function	prenyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0008299	biological_process	isoprenoid biosynthetic process
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
B	0045337	biological_process	farnesyl diphosphate biosynthetic process
C	0004161	molecular_function	dimethylallyltranstransferase activity
C	0004337	molecular_function	(2E,6E)-farnesyl diphosphate synthase activity
C	0004659	molecular_function	prenyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0008299	biological_process	isoprenoid biosynthetic process
C	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
C	0045337	biological_process	farnesyl diphosphate biosynthetic process
D	0004161	molecular_function	dimethylallyltranstransferase activity
D	0004337	molecular_function	(2E,6E)-farnesyl diphosphate synthase activity
D	0004659	molecular_function	prenyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0008299	biological_process	isoprenoid biosynthetic process
D	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
D	0045337	biological_process	farnesyl diphosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue HXK A 401

Chain	Residue
A	GLY80
A	TYR247
A	HOH503
A	HOH512
C	ASN154
C	LEU157
A	LYS81
A	ASN82
A	ARG84
A	GLN119
A	LEU123
A	ARG136
A	LYS243
A	THR244

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site_id	AC2
Number of Residues	13
Details	binding site for residue HXK B 401

Chain	Residue
B	GLY80
B	LYS81
B	ARG84
B	GLN119
B	PHE122
B	LEU123
B	ALA125
B	ARG136
B	LYS243
B	THR244
B	TYR247
B	SER248
D	LEU157

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site_id	AC3
Number of Residues	14
Details	binding site for residue HXK C 401

Chain	Residue
A	ASN154
A	LEU157
C	GLY80
C	LYS81
C	ARG84
C	GLN119
C	PHE122
C	ARG135
C	ARG136
C	LYS243
C	TYR247
C	GLN284
C	ASP287
C	HOH506

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site_id	AC4
Number of Residues	13
Details	binding site for residue HXK D 401

Chain	Residue
B	ASN154
B	LEU157
D	ARG84
D	GLN119
D	PHE122
D	THR244
D	TYR247
D	GLY280
D	PHE283
D	GLN284
D	ASP287
D	SO4402
D	HOH501

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site_id	AC5
Number of Residues	7
Details	binding site for residue SO4 D 402

Chain	Residue
D	GLY80
D	LYS81
D	GLN119
D	ARG136
D	HXK401
D	HOH501
D	HOH531

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Functional Information from PROSITE/UniProt

site_id	PS00444
Number of Residues	13
Details	POLYPRENYL_SYNTHASE_2 Polyprenyl synthases signature 2. MGeyFQIhDDYlD

Chain	Residue	Details
A	MET279-ASP291

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