Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5HN7

Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH-1158

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004161	molecular_function	dimethylallyltranstransferase activity
A	0004337	molecular_function	(2E,6E)-farnesyl diphosphate synthase activity
A	0004659	molecular_function	prenyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0008299	biological_process	isoprenoid biosynthetic process
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
A	0045337	biological_process	farnesyl diphosphate biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0004161	molecular_function	dimethylallyltranstransferase activity
B	0004337	molecular_function	(2E,6E)-farnesyl diphosphate synthase activity
B	0004659	molecular_function	prenyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0008299	biological_process	isoprenoid biosynthetic process
B	0016020	cellular_component	membrane
B	0016740	molecular_function	transferase activity
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
B	0045337	biological_process	farnesyl diphosphate biosynthetic process
B	0046872	molecular_function	metal ion binding
C	0004161	molecular_function	dimethylallyltranstransferase activity
C	0004337	molecular_function	(2E,6E)-farnesyl diphosphate synthase activity
C	0004659	molecular_function	prenyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0008299	biological_process	isoprenoid biosynthetic process
C	0016020	cellular_component	membrane
C	0016740	molecular_function	transferase activity
C	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
C	0045337	biological_process	farnesyl diphosphate biosynthetic process
C	0046872	molecular_function	metal ion binding
D	0004161	molecular_function	dimethylallyltranstransferase activity
D	0004337	molecular_function	(2E,6E)-farnesyl diphosphate synthase activity
D	0004659	molecular_function	prenyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0008299	biological_process	isoprenoid biosynthetic process
D	0016020	cellular_component	membrane
D	0016740	molecular_function	transferase activity
D	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
D	0045337	biological_process	farnesyl diphosphate biosynthetic process
D	0046872	molecular_function	metal ion binding
E	0004161	molecular_function	dimethylallyltranstransferase activity
E	0004337	molecular_function	(2E,6E)-farnesyl diphosphate synthase activity
E	0004659	molecular_function	prenyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0008299	biological_process	isoprenoid biosynthetic process
E	0016020	cellular_component	membrane
E	0016740	molecular_function	transferase activity
E	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
E	0045337	biological_process	farnesyl diphosphate biosynthetic process
E	0046872	molecular_function	metal ion binding
F	0004161	molecular_function	dimethylallyltranstransferase activity
F	0004337	molecular_function	(2E,6E)-farnesyl diphosphate synthase activity
F	0004659	molecular_function	prenyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0008299	biological_process	isoprenoid biosynthetic process
F	0016020	cellular_component	membrane
F	0016740	molecular_function	transferase activity
F	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
F	0045337	biological_process	farnesyl diphosphate biosynthetic process
F	0046872	molecular_function	metal ion binding
G	0004161	molecular_function	dimethylallyltranstransferase activity
G	0004337	molecular_function	(2E,6E)-farnesyl diphosphate synthase activity
G	0004659	molecular_function	prenyltransferase activity
G	0005737	cellular_component	cytoplasm
G	0008299	biological_process	isoprenoid biosynthetic process
G	0016020	cellular_component	membrane
G	0016740	molecular_function	transferase activity
G	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
G	0045337	biological_process	farnesyl diphosphate biosynthetic process
G	0046872	molecular_function	metal ion binding
H	0004161	molecular_function	dimethylallyltranstransferase activity
H	0004337	molecular_function	(2E,6E)-farnesyl diphosphate synthase activity
H	0004659	molecular_function	prenyltransferase activity
H	0005737	cellular_component	cytoplasm
H	0008299	biological_process	isoprenoid biosynthetic process
H	0016020	cellular_component	membrane
H	0016740	molecular_function	transferase activity
H	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
H	0045337	biological_process	farnesyl diphosphate biosynthetic process
H	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue 04M A 401

Chain	Residue
A	LYS81
A	THR199
A	LYS243
A	TYR247
A	PHE283
A	HOH623
A	HOH634
E	LYS150
E	ASN154
A	ARG84
A	GLN119
A	PHE122
A	MET129
A	ARG135
A	ARG136
A	THR191
A	GLN195

site_id	AC2
Number of Residues	23
Details	binding site for residue 04M B 401

Chain	Residue
B	GLY80
B	LYS81
B	ARG84
B	GLN119
B	PHE122
B	ALA125
B	ASP126
B	MET129
B	ARG135
B	ARG136
B	THR188
B	THR191
B	GLN195
B	LYS243
B	THR244
B	TYR247
B	SER248
B	PHE283
B	HOH586
B	HOH593
B	HOH635
C	ASN154
C	LEU157

site_id	AC3
Number of Residues	20
Details	binding site for residue 04M C 401

Chain	Residue
B	ASN154
B	LEU157
C	LYS81
C	ARG84
C	GLN119
C	PHE122
C	MET129
C	ARG136
C	GLN195
C	THR244
C	TYR247
C	SER248
C	PHE283
C	GLN284
C	ASP287
C	LYS301
C	HOH544
C	HOH580
C	HOH612
C	HOH653

site_id	AC4
Number of Residues	22
Details	binding site for residue 04M D 401

Chain	Residue
D	GLY80
D	LYS81
D	ARG84
D	GLN119
D	PHE122
D	ASP126
D	MET129
D	ARG135
D	ARG136
D	TYR160
D	THR191
D	GLN195
D	LYS243
D	THR244
D	TYR247
D	SER248
D	PHE283
D	GLN284
D	HOH569
D	HOH614
G	ASN154
G	LEU157

site_id	AC5
Number of Residues	21
Details	binding site for residue 04M E 401

Chain	Residue
E	GLN284
E	HOH525
E	HOH584
E	HOH616
A	ASN154
A	LEU157
E	LYS81
E	ARG84
E	GLN119
E	ALA121
E	PHE122
E	ASP126
E	ARG136
E	THR191
E	ILE192
E	GLN195
E	LYS243
E	THR244
E	TYR247
E	SER248
E	PHE283

site_id	AC6
Number of Residues	21
Details	binding site for residue 04M F 401

Chain	Residue
F	GLY80
F	LYS81
F	ARG84
F	GLN119
F	PHE122
F	ASP126
F	MET129
F	ARG136
F	THR191
F	GLN195
F	THR244
F	TYR247
F	SER248
F	PHE283
F	GLN284
F	ASP287
F	LYS301
F	HOH553
F	HOH556
H	ASN154
H	LEU157

site_id	AC7
Number of Residues	23
Details	binding site for residue 04M G 401

Chain	Residue
D	ASN154
D	LEU157
G	GLY80
G	LYS81
G	ARG84
G	GLN119
G	PHE122
G	ASP126
G	MET129
G	ARG135
G	ARG136
G	VAL156
G	THR191
G	GLN195
G	LYS243
G	THR244
G	TYR247
G	SER248
G	PHE283
G	GLN284
G	HOH549
G	HOH552
G	HOH605

site_id	AC8
Number of Residues	22
Details	binding site for residue 04M H 401

Chain	Residue
F	ASN154
F	LEU157
H	GLY80
H	LYS81
H	ARG84
H	GLN119
H	PHE122
H	MET129
H	ARG135
H	ARG136
H	THR191
H	ILE192
H	GLN195
H	LYS243
H	THR244
H	TYR247
H	SER248
H	PHE283
H	GLN284
H	HOH503
H	HOH586
H	HOH619

Functional Information from PROSITE/UniProt

site_id	PS00444
Number of Residues	13
Details	POLYPRENYL_SYNTHASE_2 Polyprenyl synthases signature 2. MGeyFQIhDDYlD

Chain	Residue	Details
A	MET279-ASP291

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)