5HKO

Crystal structure of ABC transporter Solute Binding Protein MSMEG_3598 from Mycobacterium smegmatis str. MC2 155, target EFI-510969, in complex with L-sorbitol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0008643	biological_process	carbohydrate transport
A	0030246	molecular_function	carbohydrate binding
A	0071322	biological_process	cellular response to carbohydrate stimulus

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 401

Chain	Residue
A	GLU50
A	GLU252
A	CL416
A	CL417

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 402

Chain	Residue
A	ASP128
A	ASP178
A	CL421
A	ACT431

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 403

Chain	Residue
A	IMD427
A	ACT432
A	HOH663
A	GLU53

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN A 404

Chain	Residue
A	ASP218
A	ACT433
A	HOH735
A	HOH736

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN A 405

Chain	Residue
A	ASP136
A	HOH724
A	HOH741
A	HOH750

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN A 406

Chain	Residue
A	GLU237
A	IMD429
A	IMD430
A	HOH713

---

site_id	AC7
Number of Residues	3
Details	binding site for residue ZN A 407

Chain	Residue
A	ASP337
A	THR347
A	HOH659

---

site_id	AC8
Number of Residues	5
Details	binding site for residue ZN A 408

Chain	Residue
A	LYS52
A	ASP56
A	ASP186
A	CL418
A	CL419

---

site_id	AC9
Number of Residues	6
Details	binding site for residue ZN A 409

Chain	Residue
A	ASP74
A	SER76
A	HOH503
A	HOH523
A	HOH653
A	HOH690

---

site_id	AD1
Number of Residues	1
Details	binding site for residue ZN A 410

Chain	Residue
A	ASP200

---

site_id	AD2
Number of Residues	3
Details	binding site for residue ZN A 411

Chain	Residue
A	ASP294
A	HOH744
A	HOH764

---

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN A 412

Chain	Residue
A	GLU170
A	CL420
A	HOH504
A	HOH746

---

site_id	AD4
Number of Residues	5
Details	binding site for residue ZN A 413

Chain	Residue
A	ASP43
A	ASN72
A	ASP150
A	CL422
A	IMD426

---

site_id	AD5
Number of Residues	6
Details	binding site for residue ZN A 414

Chain	Residue
A	ASP200
A	CL423
A	CL424
A	IMD428
A	HOH535
A	HOH753

---

site_id	AD6
Number of Residues	2
Details	binding site for residue ZN A 415

Chain	Residue
A	GLU125
A	HOH751

---

site_id	AD7
Number of Residues	5
Details	binding site for residue CL A 416

Chain	Residue
A	GLU50
A	ARG199
A	GLU252
A	ASP253
A	ZN401

---

site_id	AD8
Number of Residues	3
Details	binding site for residue CL A 417

Chain	Residue
A	GLU50
A	GLU252
A	ZN401

---

site_id	AD9
Number of Residues	3
Details	binding site for residue CL A 418

Chain	Residue
A	ASP56
A	ASP186
A	ZN408

---

site_id	AE1
Number of Residues	4
Details	binding site for residue CL A 419

Chain	Residue
A	ASP56
A	LYS60
A	ASP186
A	ZN408

---

site_id	AE2
Number of Residues	4
Details	binding site for residue CL A 420

Chain	Residue
A	GLU170
A	ZN412
A	HOH504
A	HOH746

---

site_id	AE3
Number of Residues	5
Details	binding site for residue CL A 421

Chain	Residue
A	ASP128
A	ILE160
A	ASP178
A	ZN402
A	ACT431

---

site_id	AE4
Number of Residues	8
Details	binding site for residue CL A 422

Chain	Residue
A	ASP43
A	ASN72
A	ASN73
A	ASP150
A	LYS198
A	ZN413
A	IMD426
A	IMD428

---

site_id	AE5
Number of Residues	5
Details	binding site for residue CL A 423

Chain	Residue
A	ASP200
A	ZN414
A	CL424
A	IMD426
A	IMD428

---

site_id	AE6
Number of Residues	5
Details	binding site for residue CL A 424

Chain	Residue
A	HOH535
A	HOH707
A	ZN414
A	CL423
A	IMD428

---

site_id	AE7
Number of Residues	12
Details	binding site for residue 62W A 425

Chain	Residue
A	TYR42
A	ASN121
A	ALA122
A	ARG173
A	TRP197
A	ASN224
A	ASP249
A	GLN269
A	HOH540
A	HOH561
A	HOH602
A	HOH604

---

site_id	AE8
Number of Residues	9
Details	binding site for residue IMD A 426

Chain	Residue
A	ASP43
A	MET44
A	GLN146
A	ASP150
A	ZN413
A	CL422
A	CL423
A	IMD428
A	HOH675

---

site_id	AE9
Number of Residues	6
Details	binding site for residue IMD A 427

Chain	Residue
A	GLU53
A	LYS183
A	GLU252
A	ARG318
A	ZN403
A	ACT432

---

site_id	AF1
Number of Residues	7
Details	binding site for residue IMD A 428

Chain	Residue
A	ZN414
A	CL422
A	CL423
A	CL424
A	IMD426
A	HOH535
A	HOH761

---

site_id	AF2
Number of Residues	7
Details	binding site for residue IMD A 429

Chain	Residue
A	GLU237
A	VAL296
A	ASP337
A	ZN406
A	IMD430
A	HOH621
A	HOH713

---

site_id	AF3
Number of Residues	4
Details	binding site for residue IMD A 430

Chain	Residue
A	ASP136
A	GLU237
A	ZN406
A	IMD429

---

site_id	AF4
Number of Residues	8
Details	binding site for residue ACT A 431

Chain	Residue
A	LYS111
A	ASP128
A	GLY174
A	ASP178
A	LYS192
A	ZN402
A	CL421
A	HOH557

---

site_id	AF5
Number of Residues	6
Details	binding site for residue ACT A 432

Chain	Residue
A	GLU53
A	ARG318
A	GLN319
A	ZN403
A	IMD427
A	HOH663

---

site_id	AF6
Number of Residues	3
Details	binding site for residue ACT A 433

Chain	Residue
A	PRO215
A	ASP218
A	ZN404

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26560079","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RS3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---