5HKI

Crystal structure of Mycobacterium tuberculosis H37Rv orotate phosphoribosyltransferase in complex with Fe(III) dicitrate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004588	molecular_function	orotate phosphoribosyltransferase activity
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006222	biological_process	UMP biosynthetic process
A	0016757	molecular_function	glycosyltransferase activity
A	0019856	biological_process	pyrimidine nucleobase biosynthetic process
A	0044205	biological_process	'de novo' UMP biosynthetic process
B	0000287	molecular_function	magnesium ion binding
B	0004588	molecular_function	orotate phosphoribosyltransferase activity
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006222	biological_process	UMP biosynthetic process
B	0016757	molecular_function	glycosyltransferase activity
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0044205	biological_process	'de novo' UMP biosynthetic process
C	0000287	molecular_function	magnesium ion binding
C	0004588	molecular_function	orotate phosphoribosyltransferase activity
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006222	biological_process	UMP biosynthetic process
C	0016757	molecular_function	glycosyltransferase activity
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0044205	biological_process	'de novo' UMP biosynthetic process
D	0000287	molecular_function	magnesium ion binding
D	0004588	molecular_function	orotate phosphoribosyltransferase activity
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006222	biological_process	UMP biosynthetic process
D	0016757	molecular_function	glycosyltransferase activity
D	0019856	biological_process	pyrimidine nucleobase biosynthetic process
D	0044205	biological_process	'de novo' UMP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue 6ZJ B 201

Chain	Residue
A	HIS100
B	LEU25
B	VAL35
B	ARG38
B	THR124
B	SER128

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site_id	AC2
Number of Residues	5
Details	binding site for residue 6ZJ C 201

Chain	Residue
C	SER128
D	HIS100
C	SER26
C	SER123
C	THR124

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01208

Chain	Residue	Details
C	HIS100
C	THR124
C	ARG152
D	ARG94
D	LYS98
D	HIS100
D	THR124
D	ARG152
B	THR124
B	ARG152
C	ARG94
C	LYS98
A	ARG94
A	LYS98
A	HIS100
A	THR124
A	ARG152
B	ARG94
B	LYS98
B	HIS100

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site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_01208

Chain	Residue	Details
C	LYS95
C	GLU120
D	LYS95
D	GLU120
B	GLU120
A	LYS95
A	GLU120
B	LYS95

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