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5HK1

Human sigma-1 receptor bound to PD144418

Functional Information from GO Data
ChainGOidnamespacecontents
A0004985molecular_functionG protein-coupled opioid receptor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005637cellular_componentnuclear inner membrane
A0005640cellular_componentnuclear outer membrane
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005811cellular_componentlipid droplet
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006869biological_processlipid transport
A0007399biological_processnervous system development
A0014069cellular_componentpostsynaptic density
A0016020cellular_componentmembrane
A0030426cellular_componentgrowth cone
A0031410cellular_componentcytoplasmic vesicle
A0038003biological_processG protein-coupled opioid receptor signaling pathway
A0038023molecular_functionsignaling receptor activity
A0042995cellular_componentcell projection
A0043523biological_processregulation of neuron apoptotic process
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0070161cellular_componentanchoring junction
A0070207biological_processprotein homotrimerization
A0098794cellular_componentpostsynapse
A0098839cellular_componentpostsynaptic density membrane
A0098978cellular_componentglutamatergic synapse
A0150052biological_processregulation of postsynapse assembly
B0004985molecular_functionG protein-coupled opioid receptor activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005635cellular_componentnuclear envelope
B0005637cellular_componentnuclear inner membrane
B0005640cellular_componentnuclear outer membrane
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005811cellular_componentlipid droplet
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006869biological_processlipid transport
B0007399biological_processnervous system development
B0014069cellular_componentpostsynaptic density
B0016020cellular_componentmembrane
B0030426cellular_componentgrowth cone
B0031410cellular_componentcytoplasmic vesicle
B0038003biological_processG protein-coupled opioid receptor signaling pathway
B0038023molecular_functionsignaling receptor activity
B0042995cellular_componentcell projection
B0043523biological_processregulation of neuron apoptotic process
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0070161cellular_componentanchoring junction
B0070207biological_processprotein homotrimerization
B0098794cellular_componentpostsynapse
B0098839cellular_componentpostsynaptic density membrane
B0098978cellular_componentglutamatergic synapse
B0150052biological_processregulation of postsynapse assembly
C0004985molecular_functionG protein-coupled opioid receptor activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005635cellular_componentnuclear envelope
C0005637cellular_componentnuclear inner membrane
C0005640cellular_componentnuclear outer membrane
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005811cellular_componentlipid droplet
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006869biological_processlipid transport
C0007399biological_processnervous system development
C0014069cellular_componentpostsynaptic density
C0016020cellular_componentmembrane
C0030426cellular_componentgrowth cone
C0031410cellular_componentcytoplasmic vesicle
C0038003biological_processG protein-coupled opioid receptor signaling pathway
C0038023molecular_functionsignaling receptor activity
C0042995cellular_componentcell projection
C0043523biological_processregulation of neuron apoptotic process
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0070161cellular_componentanchoring junction
C0070207biological_processprotein homotrimerization
C0098794cellular_componentpostsynapse
C0098839cellular_componentpostsynaptic density membrane
C0098978cellular_componentglutamatergic synapse
C0150052biological_processregulation of postsynapse assembly
Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue 61W A 301
ChainResidue
ALEU105
ATYR206
APHE107
ATYR120
AILE124
AASP126
AHIS154
AGLU172
ATHR181
ALEU182

site_idAC2
Number of Residues3
Detailsbinding site for residue SO4 A 302
ChainResidue
AARG208
AARG211
AHOH421

site_idAC3
Number of Residues3
Detailsbinding site for residue SO4 A 303
ChainResidue
AGLN38
AARG39
AARG175

site_idAC4
Number of Residues3
Detailsbinding site for residue SO4 A 304
ChainResidue
AASP53
AHIS54
AASN167

site_idAC5
Number of Residues1
Detailsbinding site for residue SO4 A 305
ChainResidue
AARG204

site_idAC6
Number of Residues8
Detailsbinding site for residue SO4 A 306
ChainResidue
AARG114
AHOH402
AHOH404
AHOH409
AHOH433
BARG114
CARG114
CHOH422

site_idAC7
Number of Residues5
Detailsbinding site for residue SO4 A 307
ChainResidue
AARG60
AHOH435
CSER130
CGLY131
CPRO148

site_idAC8
Number of Residues1
Detailsbinding site for residue SO4 A 308
ChainResidue
AARG137

site_idAC9
Number of Residues5
Detailsbinding site for residue OLC A 309
ChainResidue
AARG39
ATRP121
AARG175
AGLY176
CPHE219

site_idAD1
Number of Residues6
Detailsbinding site for residue OLC A 310
ChainResidue
ALEU30
AGLN33
APHE35
ALEU100
ASER101
CLEU218

site_idAD2
Number of Residues8
Detailsbinding site for residue 61W B 301
ChainResidue
BTRP89
BLEU105
BTYR120
BASP126
BHIS154
BGLU172
BLEU182
BTYR206

site_idAD3
Number of Residues4
Detailsbinding site for residue SO4 B 302
ChainResidue
BARG208
BARG211
BHOH415
BHOH425

site_idAD4
Number of Residues1
Detailsbinding site for residue SO4 B 303
ChainResidue
BARG204

site_idAD5
Number of Residues3
Detailsbinding site for residue SO4 B 304
ChainResidue
BARG39
BARG175
BHOH417

site_idAD6
Number of Residues3
Detailsbinding site for residue SO4 B 305
ChainResidue
BASP53
BHIS54
BSER130

site_idAD7
Number of Residues10
Detailsbinding site for residue 61W C 301
ChainResidue
CTRP89
CLEU105
CPHE107
CTYR120
CASP126
CHIS154
CGLU172
CTHR181
CLEU182
CTYR206

site_idAD8
Number of Residues3
Detailsbinding site for residue SO4 C 302
ChainResidue
CGLU78
CARG208
CARG211

site_idAD9
Number of Residues4
Detailsbinding site for residue SO4 C 303
ChainResidue
CGLN38
CARG39
CARG175
CHOH429

site_idAE1
Number of Residues4
Detailsbinding site for residue SO4 C 304
ChainResidue
CARG204
CARG204
CHOH404
CHOH404

site_idAE2
Number of Residues5
Detailsbinding site for residue OLC C 305
ChainResidue
ATRP27
CLEU210
CGLU213
CTYR217
COLC306

site_idAE3
Number of Residues8
Detailsbinding site for residue OLC C 306
ChainResidue
ATRP27
CTRP29
CLEU100
CSER101
COLC305
COLC307
COLC309
CHOH403

site_idAE4
Number of Residues8
Detailsbinding site for residue OLC C 307
ChainResidue
CGLN33
CPHE35
CLEU100
CSER101
CGLY176
COLC306
COLC308
CTRP29

site_idAE5
Number of Residues4
Detailsbinding site for residue OLC C 308
ChainResidue
CTRP121
CGLU123
CARG175
COLC307

site_idAE6
Number of Residues6
Detailsbinding site for residue OLC C 309
ChainResidue
AGLN24
ATRP27
BARG7
CTRP29
CTHR32
COLC306

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues24
DetailsTOPO_DOM: Lumenal => ECO:0000305|PubMed:27042935
ChainResidueDetails
AMET1-TRP9
BMET1-TRP9
CMET1-TRP9

site_idSWS_FT_FI2
Number of Residues60
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:27042935
ChainResidueDetails
AALA10-LEU30
BALA10-LEU30
CALA10-LEU30

site_idSWS_FT_FI3
Number of Residues576
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:27042935
ChainResidueDetails
AGLY31-PRO223
BGLY31-PRO223
CGLY31-PRO223

site_idSWS_FT_FI4
Number of Residues6
DetailsSITE: Important for ligand binding => ECO:0000269|PubMed:11476895
ChainResidueDetails
AASP126
AGLU172
BASP126
BGLU172
CASP126
CGLU172

224201

PDB entries from 2024-08-28

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