Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5HHF

Crystal structure of Aspergillus fumigatus UDP-Galactopyranose mutase mutant H63A with covalent FAD-Galactopyranose and bound UDP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0008767	molecular_function	UDP-galactopyranose mutase activity
A	0016853	molecular_function	isomerase activity
A	0071555	biological_process	cell wall organization
B	0000166	molecular_function	nucleotide binding
B	0008767	molecular_function	UDP-galactopyranose mutase activity
B	0016853	molecular_function	isomerase activity
B	0071555	biological_process	cell wall organization
C	0000166	molecular_function	nucleotide binding
C	0008767	molecular_function	UDP-galactopyranose mutase activity
C	0016853	molecular_function	isomerase activity
C	0071555	biological_process	cell wall organization
D	0000166	molecular_function	nucleotide binding
D	0008767	molecular_function	UDP-galactopyranose mutase activity
D	0016853	molecular_function	isomerase activity
D	0071555	biological_process	cell wall organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue SO4 A 601

Chain	Residue
A	PRO307
A	GLU308
A	ARG309
A	LYS402
A	HOH778

site_id	AC2
Number of Residues	6
Details	binding site for residue MRY A 602

Chain	Residue
A	HOH713
A	HOH722
A	GLN438
A	ASN471
A	GLU478
A	ASN482

site_id	AC3
Number of Residues	36
Details	binding site for residue 62F A 603

Chain	Residue
A	GLY14
A	GLY16
A	PRO17
A	THR18
A	ASP38
A	SER39
A	GLY45
A	LEU46
A	GLY61
A	GLY62
A	ALA63
A	VAL64
A	PHE66
A	ARG182
A	ASN207
A	GLY240
A	VAL242
A	MET269
A	TRP315
A	ARG327
A	GLU373
A	GLY418
A	TYR419
A	GLY446
A	ARG447
A	GLY456
A	ASN457
A	GLN458
A	SER461
A	UDP604
A	HOH709
A	HOH723
A	HOH729
A	HOH742
A	HOH748
A	HOH812

site_id	AC4
Number of Residues	20
Details	binding site for residue UDP A 604

Chain	Residue
A	VAL95
A	TYR104
A	PHE106
A	GLN107
A	PHE142
A	PHE158
A	MET159
A	TYR162
A	ASN163
A	TRP167
A	ARG182
A	VAL183
A	TYR317
A	ARG327
A	TYR419
A	TYR453
A	62F603
A	HOH709
A	HOH746
A	HOH812

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 B 601

Chain	Residue
B	PRO307
B	GLU308
B	ARG309
B	LYS402
B	HOH764

site_id	AC6
Number of Residues	2
Details	binding site for residue SO4 B 602

Chain	Residue
B	LYS70
B	ARG496

site_id	AC7
Number of Residues	6
Details	binding site for residue MRY B 603

Chain	Residue
B	GLN438
B	ASN471
B	GLU478
B	ASN482
B	HOH722
D	HOH729

site_id	AC8
Number of Residues	34
Details	binding site for residue 62F B 604

Chain	Residue
B	ARG327
B	GLU373
B	TYR419
B	GLY446
B	ARG447
B	GLY456
B	ASN457
B	GLN458
B	SER461
B	UDP605
B	HOH701
B	HOH705
B	HOH712
B	HOH716
B	HOH781
B	GLY14
B	GLY16
B	PRO17
B	THR18
B	ASP38
B	SER39
B	GLY45
B	LEU46
B	GLY61
B	GLY62
B	ALA63
B	VAL64
B	PHE66
B	ARG182
B	ASN207
B	GLY240
B	VAL242
B	THR268
B	MET269

site_id	AC9
Number of Residues	20
Details	binding site for residue UDP B 605

Chain	Residue
B	VAL95
B	TYR104
B	PHE106
B	GLN107
B	PHE142
B	PHE158
B	MET159
B	TYR162
B	ASN163
B	TRP167
B	ARG182
B	VAL183
B	TYR317
B	ARG327
B	TYR419
B	TYR453
B	62F604
B	HOH714
B	HOH720
B	HOH781

site_id	AD1
Number of Residues	4
Details	binding site for residue SO4 C 601

Chain	Residue
C	PRO307
C	GLU308
C	ARG309
C	HOH765

site_id	AD2
Number of Residues	2
Details	binding site for residue SO4 C 602

Chain	Residue
C	THR152
C	ARG160

site_id	AD3
Number of Residues	2
Details	binding site for residue SO4 C 603

Chain	Residue
B	ASN248
C	ARG496

site_id	AD4
Number of Residues	2
Details	binding site for residue SO4 C 604

Chain	Residue
C	PRO114
C	LYS115

site_id	AD5
Number of Residues	5
Details	binding site for residue MRY C 605

Chain	Residue
C	GLN438
C	ASN471
C	GLU478
C	ASN482
C	HOH740

site_id	AD6
Number of Residues	29
Details	binding site for residue FDA C 606

Chain	Residue
C	GLY14
C	GLY16
C	PRO17
C	THR18
C	ASP38
C	SER39
C	GLY45
C	LEU46
C	ALA63
C	VAL64
C	GLY240
C	LYS241
C	VAL242
C	THR268
C	MET269
C	THR295
C	GLU373
C	GLY418
C	TYR419
C	GLY446
C	ARG447
C	GLY456
C	ASN457
C	GLN458
C	SER461
C	HOH726
C	HOH749
C	HOH813
C	HOH814

site_id	AD7
Number of Residues	5
Details	binding site for residue SO4 D 601

Chain	Residue
D	PRO307
D	GLU308
D	ARG309
D	LYS402
D	HOH749

site_id	AD8
Number of Residues	2
Details	binding site for residue SO4 D 602

Chain	Residue
D	PRO114
D	LYS115

site_id	AD9
Number of Residues	3
Details	binding site for residue SO4 D 603

Chain	Residue
D	THR152
D	ARG160
D	HOH726

site_id	AE1
Number of Residues	7
Details	binding site for residue MRY D 604

Chain	Residue
D	GLN438
D	ASN471
D	GLU478
D	ASN482
D	HOH761
D	HOH766
D	HOH797

site_id	AE2
Number of Residues	23
Details	binding site for residue FDA D 605

Chain	Residue
D	GLY14
D	GLY16
D	PRO17
D	THR18
D	ASP38
D	SER39
D	GLY45
D	LEU46
D	ALA47
D	VAL64
D	GLY240
D	VAL242
D	MET269
D	THR295
D	GLY418
D	GLY446
D	ARG447
D	GLY456
D	ASN457
D	GLN458
D	SER461
D	HOH713
D	HOH728

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	BINDING: BINDING => ECO:0000269\|PubMed:22294687, ECO:0000269\|PubMed:22334662, ECO:0007744\|PDB:3UKA, ECO:0007744\|PDB:3UKH, ECO:0007744\|PDB:3UKK, ECO:0007744\|PDB:3UKL, ECO:0007744\|PDB:3UKP, ECO:0007744\|PDB:3UTE

Chain	Residue	Details
A	THR18
B	ASP38
B	LEU46
B	ALA63
B	VAL242
B	GLY456
B	GLN458
B	SER461
C	THR18
C	ASP38
C	LEU46
A	ASP38
C	ALA63
C	VAL242
C	GLY456
C	GLN458
C	SER461
D	THR18
D	ASP38
D	LEU46
D	ALA63
D	VAL242
A	LEU46
D	GLY456
D	GLN458
D	SER461
A	ALA63
A	VAL242
A	GLY456
A	GLN458
A	SER461
B	THR18

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:22334662, ECO:0007744\|PDB:3UKP

Chain	Residue	Details
A	GLY61
B	GLY61
C	GLY61
D	GLY61

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:22334662, ECO:0007744\|PDB:3UKF, ECO:0007744\|PDB:3UKP, ECO:0007744\|PDB:3UKQ

Chain	Residue	Details
A	GLY62
B	GLY62
C	GLY62
D	GLY62

site_id	SWS_FT_FI4
Number of Residues	28
Details	BINDING: BINDING => ECO:0000269\|PubMed:23036087, ECO:0007744\|PDB:5VWT

Chain	Residue	Details
A	HIS68
B	SER93
B	ASN203
B	TRP315
B	ARG447
B	HIS460
C	HIS68
C	ARG91
C	SER93
C	ASN203
C	TRP315
A	ARG91
C	ARG447
C	HIS460
D	HIS68
D	ARG91
D	SER93
D	ASN203
D	TRP315
D	ARG447
D	HIS460
A	SER93
A	ASN203
A	TRP315
A	ARG447
A	HIS460
B	HIS68
B	ARG91

site_id	SWS_FT_FI5
Number of Residues	32
Details	BINDING: BINDING => ECO:0000269\|PubMed:22294687, ECO:0000269\|PubMed:22334662, ECO:0007744\|PDB:3UKF, ECO:0007744\|PDB:3UKH, ECO:0007744\|PDB:3UKP, ECO:0007744\|PDB:3UKQ, ECO:0007744\|PDB:3UTH

Chain	Residue	Details
A	TYR104
B	GLN107
B	ASN163
B	TRP167
B	ARG182
B	ASN207
B	TYR419
B	TYR453
C	TYR104
C	GLN107
C	ASN163
A	GLN107
C	TRP167
C	ARG182
C	ASN207
C	TYR419
C	TYR453
D	TYR104
D	GLN107
D	ASN163
D	TRP167
D	ARG182
A	ASN163
D	ASN207
D	TYR419
D	TYR453
A	TRP167
A	ARG182
A	ASN207
A	TYR419
A	TYR453
B	TYR104

site_id	SWS_FT_FI6
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:22334662, ECO:0007744\|PDB:3UKH, ECO:0007744\|PDB:3UKP

Chain	Residue	Details
A	MET159
A	TYR162
B	MET159
B	TYR162
C	MET159
C	TYR162
D	MET159
D	TYR162

site_id	SWS_FT_FI7
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:22294687, ECO:0000269\|PubMed:22334662, ECO:0007744\|PDB:3UKH, ECO:0007744\|PDB:3UKQ, ECO:0007744\|PDB:3UTH

Chain	Residue	Details
A	TYR317
B	TYR317
C	TYR317
D	TYR317

site_id	SWS_FT_FI8
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:22294687, ECO:0000269\|PubMed:22334662, ECO:0007744\|PDB:3UKF, ECO:0007744\|PDB:3UKH, ECO:0007744\|PDB:3UTH

Chain	Residue	Details
A	ARG327
B	ARG327
C	ARG327
D	ARG327

site_id	SWS_FT_FI9
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:22334662, ECO:0007744\|PDB:3UKH

Chain	Residue	Details
A	ASN457
B	ASN457
C	ASN457
D	ASN457

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)