5HH3
OxyA from Actinoplanes teichomyceticus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0006707 | biological_process | cholesterol catabolic process |
| A | 0008395 | molecular_function | steroid hydroxylase activity |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0020037 | molecular_function | heme binding |
| A | 0036199 | molecular_function | cholest-4-en-3-one 26-monooxygenase activity |
| A | 0046872 | molecular_function | metal ion binding |
| C | 0004497 | molecular_function | monooxygenase activity |
| C | 0005506 | molecular_function | iron ion binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0006707 | biological_process | cholesterol catabolic process |
| C | 0008395 | molecular_function | steroid hydroxylase activity |
| C | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| C | 0020037 | molecular_function | heme binding |
| C | 0036199 | molecular_function | cholest-4-en-3-one 26-monooxygenase activity |
| C | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue HEM A 401 |
| Chain | Residue |
| A | LEU85 |
| A | THR282 |
| A | HIS283 |
| A | ARG285 |
| A | LEU308 |
| A | ALA334 |
| A | PHE335 |
| A | GLY336 |
| A | ILE339 |
| A | HIS340 |
| A | CYS342 |
| A | THR86 |
| A | GLY344 |
| A | LEU347 |
| A | HOH535 |
| A | HOH549 |
| C | GLY-5 |
| A | HIS93 |
| A | ARG97 |
| A | PHE228 |
| A | ALA232 |
| A | GLY233 |
| A | GLN236 |
| A | THR278 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 402 |
| Chain | Residue |
| A | ARG97 |
| A | ALA101 |
| A | HIS341 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | ARG274 |
| A | ASN312 |
| A | ARG314 |
| A | ASN315 |
| A | GLU320 |
| A | ASP321 |
| A | ARG327 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 404 |
| Chain | Residue |
| A | PHE104 |
| A | CYS342 |
| A | LEU343 |
| A | ARG345 |
| A | SER346 |
| site_id | AC5 |
| Number of Residues | 22 |
| Details | binding site for residue HEM C 401 |
| Chain | Residue |
| C | LEU85 |
| C | THR86 |
| C | HIS93 |
| C | ARG97 |
| C | PHE228 |
| C | GLY233 |
| C | GLN236 |
| C | VAL237 |
| C | THR278 |
| C | THR282 |
| C | HIS283 |
| C | ARG285 |
| C | LEU308 |
| C | ALA334 |
| C | PHE335 |
| C | GLY336 |
| C | ILE339 |
| C | HIS340 |
| C | CYS342 |
| C | GLY344 |
| C | HOH559 |
| C | HOH566 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 402 |
| Chain | Residue |
| A | ARG174 |
| C | GLY44 |
| C | ARG95 |
| C | ARG98 |
| C | MET99 |
| C | HOH626 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 403 |
| Chain | Residue |
| C | GLY131 |
| C | GLY132 |
| C | ASP390 |
| C | TRP391 |
| C | HOH584 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 404 |
| Chain | Residue |
| C | ASP270 |
| C | GLU331 |
| C | HIS332 |
| C | ARG345 |
| C | HOH533 |
| C | HOH552 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 405 |
| Chain | Residue |
| C | THR0 |
| C | MET1 |
| C | PHE2 |
| C | GLU3 |
| C | GLU4 |
| C | ARG46 |
| C | HOH536 |
| C | HOH538 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue GOL C 406 |
| Chain | Residue |
| A | ARG46 |
| C | GLU12 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 407 |
| Chain | Residue |
| C | ARG18 |
| C | LEU247 |
| C | ASP250 |
| C | ASP251 |
| C | TYR275 |
| C | HOH558 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 408 |
| Chain | Residue |
| C | HOH511 |
| C | ARG314 |
| C | ASN315 |
| C | GLU320 |
| C | ARG327 |
| C | GLU331 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue ACT C 409 |
| Chain | Residue |
| C | ALA232 |
| C | ASP235 |
| C | GLN236 |
| C | ARG239 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue ACT C 410 |
| Chain | Residue |
| C | GLU128 |
| C | ARG362 |
Functional Information from PROSITE/UniProt
| site_id | PS00086 |
| Number of Residues | 10 |
| Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGhGIHHCLG |
| Chain | Residue | Details |
| A | PHE335-GLY344 |
