5HH1

Crystal structure of human Naa60 mutant - F34A in complex with CoA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004596	molecular_function	peptide alpha-N-acetyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	binding site for residue COA A 201

Chain	Residue
A	TRP33
A	GLY113
A	SER114
A	ASN143
A	THR145
A	PHE149
A	ASN152
A	ARG153
A	HOH302
A	HOH313
A	HOH322
A	SER100
A	HOH351
A	HOH364
A	HOH379
A	HOH410
A	HOH442
A	LEU101
A	GLY102
A	VAL103
A	ARG108
A	LYS109
A	HIS110
A	GLY111

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	191
Details	TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:25732826

Chain	Residue	Details
A	MET1-ASP192

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:27320834, ECO:0000269|PubMed:27550639

Chain	Residue	Details
A	TYR97
A	HIS138

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site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:27320834, ECO:0000312|PDB:5ICV, ECO:0000312|PDB:5ICW

Chain	Residue	Details
A	TYR165
A	TYR38
A	LEU99

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site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:27320834, ECO:0000269|PubMed:27550639, ECO:0000312|PDB:5HGZ, ECO:0000312|PDB:5HH0, ECO:0000312|PDB:5HH1, ECO:0000312|PDB:5ICV, ECO:0000312|PDB:5ICW

Chain	Residue	Details
A	LYS109
A	ASN143
A	TYR150
A	LEU101

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site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Required to position thioacetyl group => ECO:0000269|PubMed:27550639

Chain	Residue	Details
A	ALA34

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site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:21981917

Chain	Residue	Details
A	LYS105
A	LYS156
A	LYS79

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site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000305|PubMed:21981917

Chain	Residue	Details
A	LYS109
A	LYS121

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