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5HG1

Crystal Structure of Human Hexokinase 2 with cmpd 1, a C-2-substituted glucosamine

Functional Information from GO Data
ChainGOidnamespacecontents
A0001666biological_processresponse to hypoxia
A0001678biological_processintracellular glucose homeostasis
A0002931biological_processresponse to ischemia
A0004340molecular_functionglucokinase activity
A0004396molecular_functionhexokinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005536molecular_functionD-glucose binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005975biological_processcarbohydrate metabolic process
A0006002biological_processfructose 6-phosphate metabolic process
A0006006biological_processglucose metabolic process
A0006096biological_processglycolytic process
A0007595biological_processlactation
A0008637biological_processapoptotic mitochondrial changes
A0008865molecular_functionfructokinase activity
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0016529cellular_componentsarcoplasmic reticulum
A0016773molecular_functionphosphotransferase activity, alcohol group as acceptor
A0019318biological_processhexose metabolic process
A0035795biological_processnegative regulation of mitochondrial membrane permeability
A0043231cellular_componentintracellular membrane-bounded organelle
A0045766biological_processpositive regulation of angiogenesis
A0046324biological_processregulation of D-glucose import
A0046835biological_processcarbohydrate phosphorylation
A0051156biological_processglucose 6-phosphate metabolic process
A0061621biological_processcanonical glycolysis
A0072655biological_processestablishment of protein localization to mitochondrion
A0072656biological_processmaintenance of protein location in mitochondrion
A1905091biological_processpositive regulation of type 2 mitophagy
A1990830biological_processcellular response to leukemia inhibitory factor
A2000378biological_processnegative regulation of reactive oxygen species metabolic process
Functional Information from PROSITE/UniProt
site_idPS00378
Number of Residues26
DetailsHEXOKINASE_1 Hexokinase domain signature. LGFTFSFPchqtkLDesfLvsWTKgF
ChainResidueDetails
ALEU150-PHE175
ALEU598-PHE623

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P19367
ChainResidueDetails
AARG30
ALYS425
AGLY747
ATHR784
ATHR863

site_idSWS_FT_FI2
Number of Residues17
DetailsBINDING: BINDING => ECO:0000269|PubMed:29298880, ECO:0007744|PDB:2NZT
ChainResidueDetails
AASP84
AASP413
ASER449
ASER603
ATHR620
AASN656
ASER682
AGLU708
AGLN739
ASER155
ATHR172
AASN208
AASP209
ATHR232
AASN235
AGLU260
AGLN291

site_idSWS_FT_FI3
Number of Residues5
DetailsBINDING: BINDING => ECO:0000269|PubMed:26985301, ECO:0000269|PubMed:29298880, ECO:0007744|PDB:2NZT, ECO:0007744|PDB:5HG1
ChainResidueDetails
AASP532
AASP657
ATHR680
AASP861
ASER897

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PDB entries from 2024-11-06

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