5HEL

Crystal structure of the N-terminus Y153H bromodomain mutant of human BRD2

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue EDO A 201

Chain	Residue
A	LEU110
A	ASN156
A	HOH305
A	HOH389

---

site_id	AC2
Number of Residues	7
Details	binding site for residue EDO A 202

Chain	Residue
A	HOH303
A	HOH370
A	ARG129
A	GLU140
A	GLN143
A	ASP144
A	HOH302

---

site_id	AC3
Number of Residues	6
Details	binding site for residue EDO A 203

Chain	Residue
A	GLN94
A	TRP97
A	PRO158
A	HOH341
A	HOH360
A	HOH362

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFrqpvDavklglpDYHkiIkqpMdmgtIkrrlenny..Ywaasecmqdfnt.MftNChiY

Chain	Residue	Details
A	ALA96-TYR155

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:37731000, ECO:0007744|PDB:8SB6

Chain	Residue	Details
A	ASP112
A	TYR155
A	ASN156
A	LYS157

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:20048151, ECO:0007744|PDB:2DVQ, ECO:0007744|PDB:2DVS

Chain	Residue	Details
A	ASP160
A	ASP161

---