5HEL
Crystal structure of the N-terminus Y153H bromodomain mutant of human BRD2
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 201 |
| Chain | Residue |
| A | LEU110 |
| A | ASN156 |
| A | HOH305 |
| A | HOH389 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 202 |
| Chain | Residue |
| A | HOH303 |
| A | HOH370 |
| A | ARG129 |
| A | GLU140 |
| A | GLN143 |
| A | ASP144 |
| A | HOH302 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 203 |
| Chain | Residue |
| A | GLN94 |
| A | TRP97 |
| A | PRO158 |
| A | HOH341 |
| A | HOH360 |
| A | HOH362 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFrqpvDavklglpDYHkiIkqpMdmgtIkrrlenny..Ywaasecmqdfnt.MftNChiY |
| Chain | Residue | Details |
| A | ALA96-TYR155 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 106 |
| Details | Domain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37731000","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SB6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20048151","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DVS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
