5HDK
Crystal structure of heat shock factor 2-DBD
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0043565 | molecular_function | sequence-specific DNA binding |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0043565 | molecular_function | sequence-specific DNA binding |
| D | 0003700 | molecular_function | DNA-binding transcription factor activity |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0043565 | molecular_function | sequence-specific DNA binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue K A 201 |
| Chain | Residue |
| A | LEU17 |
| A | VAL18 |
| A | GLU20 |
| A | THR23 |
| A | ASN24 |
| A | ILE27 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 202 |
| Chain | Residue |
| A | LYS97 |
| A | GLN100 |
| A | LEU104 |
| A | TRP15 |
| A | TYR95 |
| A | PHE96 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 203 |
| Chain | Residue |
| A | ASN66 |
| A | PHE70 |
| D | HIS75 |
| D | ILE76 |
| D | CL204 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 204 |
| Chain | Residue |
| A | GLN34 |
| A | SER35 |
| A | GLN92 |
| A | HIS93 |
| A | PHE96 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue K B 201 |
| Chain | Residue |
| B | LEU17 |
| B | VAL18 |
| B | GLU20 |
| B | THR23 |
| B | ASN24 |
| B | ILE27 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 202 |
| Chain | Residue |
| B | GLN31 |
| B | HOH375 |
| D | THR28 |
| D | K203 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 203 |
| Chain | Residue |
| B | ARG63 |
| B | ASN66 |
| B | MET67 |
| B | HOH402 |
| B | HOH409 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 204 |
| Chain | Residue |
| B | GLN34 |
| B | GLN92 |
| B | HIS93 |
| B | PHE96 |
| B | LYS97 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 205 |
| Chain | Residue |
| B | VAL18 |
| B | ASN24 |
| B | THR28 |
| B | TRP29 |
| D | HOH389 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue K C 201 |
| Chain | Residue |
| C | LEU17 |
| C | VAL18 |
| C | GLU20 |
| C | THR23 |
| C | ASN24 |
| C | ILE27 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue NA C 202 |
| Chain | Residue |
| C | GLN34 |
| C | SER35 |
| C | GLN92 |
| C | HIS93 |
| C | PHE96 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue K D 201 |
| Chain | Residue |
| B | ASN32 |
| B | HOH315 |
| B | HOH370 |
| B | HOH375 |
| C | ARG71 |
| D | GLU25 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue K D 202 |
| Chain | Residue |
| D | LEU17 |
| D | VAL18 |
| D | GLU20 |
| D | THR23 |
| D | ASN24 |
| D | ILE27 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue K D 203 |
| Chain | Residue |
| B | CL202 |
| B | HOH370 |
| B | HOH414 |
| D | ASN24 |
| D | LEU39 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue CL D 204 |
| Chain | Residue |
| A | ASN66 |
| A | LYS110 |
| A | NA203 |
| A | HOH361 |
| B | PHE26 |
| D | HIS75 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue CL D 205 |
| Chain | Residue |
| B | ASN32 |
| B | HOH375 |
| B | HOH377 |
| B | HOH401 |
| D | ASN24 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue NA D 206 |
| Chain | Residue |
| D | GLN34 |
| D | SER35 |
| D | GLN92 |
| D | HIS93 |
| D | PHE96 |
| D | LYS97 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue NA D 207 |
| Chain | Residue |
| D | VAL18 |
| D | ASN24 |
| D | THR28 |
| D | TRP29 |
Functional Information from PROSITE/UniProt
| site_id | PS00434 |
| Number of Residues | 25 |
| Details | HSF_DOMAIN HSF-type DNA-binding domain signature. LpkyFKHnNmASFVRQLNmYgFRKV |
| Chain | Residue | Details |
| A | LEU49-VAL73 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
