5HAP
OXA-48 beta-lactamase - S70A mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008658 | molecular_function | penicillin binding |
| A | 0008800 | molecular_function | beta-lactamase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0071555 | biological_process | cell wall organization |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008658 | molecular_function | penicillin binding |
| B | 0008800 | molecular_function | beta-lactamase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0071555 | biological_process | cell wall organization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 301 |
| Chain | Residue |
| A | ARG206 |
| A | HOH553 |
| B | ARG206 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue 1PE A 302 |
| Chain | Residue |
| A | ALA65 |
| A | PRO217 |
| A | HOH468 |
| B | ASN146 |
| B | ASP148 |
| B | GLY161 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue PGE A 303 |
| Chain | Residue |
| A | GLN98 |
| B | ARG134 |
| B | LYS137 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue PGE A 304 |
| Chain | Residue |
| A | ARG174 |
| A | LYS175 |
| A | HIS178 |
| A | LYS180 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 305 |
| Chain | Residue |
| A | ASN63 |
| A | HOH483 |
| A | HOH506 |
| B | ASN63 |
| B | HOH417 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 306 |
| Chain | Residue |
| A | ARG128 |
| A | HOH499 |
| B | GLN129 |
| B | ARG134 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 307 |
| Chain | Residue |
| A | ASP82 |
| A | SER184 |
| A | ARG186 |
| A | HOH505 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue PEG A 308 |
| Chain | Residue |
| A | ILE102 |
| A | THR104 |
| A | TYR117 |
| A | HOH410 |
| A | HOH512 |
| B | PEG303 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue PEG A 309 |
| Chain | Residue |
| A | LEU228 |
| A | ASP229 |
| A | HOH402 |
| A | HOH435 |
| A | HOH445 |
| B | ASN110 |
| B | ILE112 |
| B | THR113 |
| B | LYS116 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue MPD A 310 |
| Chain | Residue |
| A | TRP47 |
| A | ILE170 |
| A | SER171 |
| A | ARG174 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue NA B 301 |
| Chain | Residue |
| B | ASN179 |
| B | HOH438 |
| B | HOH468 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue PEG B 302 |
| Chain | Residue |
| B | ARG174 |
| B | HIS178 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue PEG B 303 |
| Chain | Residue |
| A | TYR117 |
| A | PEG308 |
| A | HOH410 |
| B | ASP202 |
| B | HOH401 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue PEG B 304 |
| Chain | Residue |
| B | TRP47 |
| B | ARG174 |
| site_id | AD6 |
| Number of Residues | 1 |
| Details | binding site for residue PG4 B 306 |
| Chain | Residue |
| B | ASP82 |
| site_id | AD7 |
| Number of Residues | 1 |
| Details | binding site for residue EDO B 307 |
| Chain | Residue |
| B | GLU185 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 308 |
| Chain | Residue |
| A | ASP229 |
| B | ASP108 |
| B | ASN110 |
| B | THR113 |
| site_id | AD9 |
| Number of Residues | 1 |
| Details | binding site for residue EDO B 309 |
| Chain | Residue |
| B | HIS178 |
| site_id | AE1 |
| Number of Residues | 1 |
| Details | binding site for residue EDO B 310 |
| Chain | Residue |
| B | THR99 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25406838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26731698","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31358584","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32150407","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WMC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FAQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6V1O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8RLA6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P13661","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19477418","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25406838","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3HBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WMC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
