5H8J
Crystal structure of Medicago truncatula N-carbamoylputrescine amidohydrolase (MtCPA) in complex with cadaverine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006596 | biological_process | polyamine biosynthetic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| A | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| A | 0050126 | molecular_function | N-carbamoylputrescine amidase activity |
| B | 0006596 | biological_process | polyamine biosynthetic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| B | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| B | 0050126 | molecular_function | N-carbamoylputrescine amidase activity |
| C | 0006596 | biological_process | polyamine biosynthetic process |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| C | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| C | 0050126 | molecular_function | N-carbamoylputrescine amidase activity |
| D | 0006596 | biological_process | polyamine biosynthetic process |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| D | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| D | 0050126 | molecular_function | N-carbamoylputrescine amidase activity |
| E | 0006596 | biological_process | polyamine biosynthetic process |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| E | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| E | 0050126 | molecular_function | N-carbamoylputrescine amidase activity |
| F | 0006596 | biological_process | polyamine biosynthetic process |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| F | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| F | 0050126 | molecular_function | N-carbamoylputrescine amidase activity |
| G | 0006596 | biological_process | polyamine biosynthetic process |
| G | 0016787 | molecular_function | hydrolase activity |
| G | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| G | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| G | 0050126 | molecular_function | N-carbamoylputrescine amidase activity |
| H | 0006596 | biological_process | polyamine biosynthetic process |
| H | 0016787 | molecular_function | hydrolase activity |
| H | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| H | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| H | 0050126 | molecular_function | N-carbamoylputrescine amidase activity |
| I | 0006596 | biological_process | polyamine biosynthetic process |
| I | 0016787 | molecular_function | hydrolase activity |
| I | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| I | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| I | 0050126 | molecular_function | N-carbamoylputrescine amidase activity |
| J | 0006596 | biological_process | polyamine biosynthetic process |
| J | 0016787 | molecular_function | hydrolase activity |
| J | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| J | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| J | 0050126 | molecular_function | N-carbamoylputrescine amidase activity |
| K | 0006596 | biological_process | polyamine biosynthetic process |
| K | 0016787 | molecular_function | hydrolase activity |
| K | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| K | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| K | 0050126 | molecular_function | N-carbamoylputrescine amidase activity |
| L | 0006596 | biological_process | polyamine biosynthetic process |
| L | 0016787 | molecular_function | hydrolase activity |
| L | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| L | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| L | 0050126 | molecular_function | N-carbamoylputrescine amidase activity |
| M | 0006596 | biological_process | polyamine biosynthetic process |
| M | 0016787 | molecular_function | hydrolase activity |
| M | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| M | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| M | 0050126 | molecular_function | N-carbamoylputrescine amidase activity |
| N | 0006596 | biological_process | polyamine biosynthetic process |
| N | 0016787 | molecular_function | hydrolase activity |
| N | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| N | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| N | 0050126 | molecular_function | N-carbamoylputrescine amidase activity |
| O | 0006596 | biological_process | polyamine biosynthetic process |
| O | 0016787 | molecular_function | hydrolase activity |
| O | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| O | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| O | 0050126 | molecular_function | N-carbamoylputrescine amidase activity |
| P | 0006596 | biological_process | polyamine biosynthetic process |
| P | 0016787 | molecular_function | hydrolase activity |
| P | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| P | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| P | 0050126 | molecular_function | N-carbamoylputrescine amidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 401 |
| Chain | Residue |
| A | ASP194 |
| A | HIS198 |
| B | MET273 |
| B | TRP277 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 402 |
| Chain | Residue |
| A | HOH635 |
| B | SER195 |
| B | HIS198 |
| A | MET273 |
| A | TRP277 |
| A | HOH521 |
| A | HOH535 |
| A | HOH564 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue PEG A 403 |
| Chain | Residue |
| A | HOH511 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 404 |
| Chain | Residue |
| A | ASN137 |
| A | HOH620 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 405 |
| Chain | Residue |
| A | ARG283 |
| A | PRO285 |
| A | ASP286 |
| A | HOH524 |
| A | HOH541 |
| B | VAL300 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue N2P B 401 |
| Chain | Residue |
| A | TRP277 |
| A | HOH523 |
| B | TYR54 |
| B | TYR130 |
| B | GLU132 |
| B | CYS158 |
| B | ALA183 |
| B | GLU187 |
| B | HOH538 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 402 |
| Chain | Residue |
| B | ARG66 |
| B | PHE95 |
| B | HOH502 |
| B | HOH542 |
| B | HOH547 |
| B | HOH570 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue PGE B 403 |
| Chain | Residue |
| A | ASP295 |
| B | ALA171 |
| B | LEU172 |
| B | ARG274 |
| B | HOH577 |
| B | HOH598 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue N2P C 401 |
| Chain | Residue |
| C | TYR54 |
| C | TYR130 |
| C | GLU132 |
| C | CYS158 |
| C | ALA183 |
| C | GLU187 |
| C | HOH505 |
| C | HOH529 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 402 |
| Chain | Residue |
| C | SER195 |
| C | HIS198 |
| C | HOH503 |
| C | HOH555 |
| C | HOH603 |
| D | MET273 |
| D | TRP277 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue GOL C 403 |
| Chain | Residue |
| C | SER23 |
| C | PRO74 |
| C | THR75 |
| C | ARG78 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 404 |
| Chain | Residue |
| C | VAL22 |
| C | GLU51 |
| C | GLY52 |
| C | PHE55 |
| C | ARG66 |
| C | HOH515 |
| C | HOH527 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO C 405 |
| Chain | Residue |
| C | ARG283 |
| C | PRO285 |
| C | ASP286 |
| C | HOH543 |
| C | HOH590 |
| E | PRO138 |
| F | HOH513 |
| site_id | AD5 |
| Number of Residues | 10 |
| Details | binding site for residue N2P D 401 |
| Chain | Residue |
| C | TRP277 |
| D | GLU48 |
| D | TYR54 |
| D | PRO125 |
| D | GLU132 |
| D | CYS158 |
| D | ALA183 |
| D | GLU187 |
| D | HOH528 |
| D | HOH593 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL D 402 |
| Chain | Residue |
| C | MET273 |
| C | TRP277 |
| D | HIS198 |
| D | HOH549 |
| D | HOH567 |
| D | HOH746 |
| site_id | AD7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO D 403 |
| Chain | Residue |
| D | ASP112 |
| D | GLY113 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue N2P E 401 |
| Chain | Residue |
| F | HOH529 |
| E | TYR54 |
| E | GLU132 |
| E | CYS158 |
| E | ALA183 |
| E | GLU187 |
| E | HOH516 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue GOL E 402 |
| Chain | Residue |
| E | MET273 |
| E | TRP277 |
| E | HOH529 |
| F | HIS198 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL E 403 |
| Chain | Residue |
| E | VAL22 |
| E | SER23 |
| E | THR75 |
| E | ARG78 |
| E | HOH518 |
| site_id | AE2 |
| Number of Residues | 9 |
| Details | binding site for residue GOL F 401 |
| Chain | Residue |
| E | SER195 |
| E | HIS198 |
| F | LEU211 |
| F | MET273 |
| F | TRP277 |
| F | HOH502 |
| F | HOH507 |
| F | HOH558 |
| F | HOH642 |
| site_id | AE3 |
| Number of Residues | 10 |
| Details | binding site for residue N2P F 402 |
| Chain | Residue |
| E | TRP277 |
| F | GLU48 |
| F | TYR54 |
| F | TYR130 |
| F | GLU132 |
| F | CYS158 |
| F | ALA183 |
| F | GLU187 |
| F | HOH520 |
| F | HOH543 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL F 403 |
| Chain | Residue |
| F | SER23 |
| F | PRO74 |
| F | THR75 |
| F | ARG78 |
| site_id | AE5 |
| Number of Residues | 7 |
| Details | binding site for residue EDO F 404 |
| Chain | Residue |
| C | HOH516 |
| D | HOH619 |
| E | VAL300 |
| F | PRO285 |
| F | ASP286 |
| F | HOH553 |
| F | HOH636 |
| site_id | AE6 |
| Number of Residues | 9 |
| Details | binding site for residue N2P G 401 |
| Chain | Residue |
| G | TYR54 |
| G | PRO125 |
| G | GLU132 |
| G | CYS158 |
| G | ALA183 |
| G | GLU187 |
| G | HOH538 |
| G | HOH549 |
| H | TRP277 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue PEG G 402 |
| Chain | Residue |
| G | ARG7 |
| G | GLN147 |
| G | LYS152 |
| G | HOH502 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL G 403 |
| Chain | Residue |
| G | GLU257 |
| G | HOH504 |
| G | HOH505 |
| L | LEU32 |
| L | GLU258 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL H 401 |
| Chain | Residue |
| G | HIS198 |
| G | HOH539 |
| H | THR246 |
| H | MET273 |
| H | TRP277 |
| site_id | AF1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL I 401 |
| Chain | Residue |
| I | MET273 |
| I | TRP277 |
| I | HOH505 |
| I | HOH507 |
| I | HOH564 |
| I | HOH648 |
| J | HIS198 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue GOL I 402 |
| Chain | Residue |
| I | SER23 |
| I | THR75 |
| I | ARG78 |
| I | HOH511 |
| site_id | AF3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL I 403 |
| Chain | Residue |
| I | TYR54 |
| I | GLN57 |
| I | TYR130 |
| I | ALA183 |
| I | ILE184 |
| I | GLY185 |
| site_id | AF4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO I 404 |
| Chain | Residue |
| I | PRO285 |
| I | ASP286 |
| I | HOH549 |
| J | VAL300 |
| K | HOH593 |
| L | HOH512 |
| site_id | AF5 |
| Number of Residues | 8 |
| Details | binding site for residue N2P J 401 |
| Chain | Residue |
| I | TRP277 |
| I | HOH518 |
| J | TYR54 |
| J | GLU132 |
| J | CYS158 |
| J | ALA183 |
| J | GLU187 |
| J | HOH527 |
| site_id | AF6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO J 402 |
| Chain | Residue |
| J | ARG274 |
| J | PHE280 |
| J | HOH547 |
| J | HOH662 |
| site_id | AF7 |
| Number of Residues | 9 |
| Details | binding site for residue N2P K 401 |
| Chain | Residue |
| K | TYR54 |
| K | TYR130 |
| K | GLU132 |
| K | CYS158 |
| K | ALA183 |
| K | GLU187 |
| K | HOH510 |
| L | TRP277 |
| L | HOH526 |
| site_id | AF8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL K 402 |
| Chain | Residue |
| K | HIS198 |
| K | HOH503 |
| K | HOH585 |
| K | HOH608 |
| L | MET273 |
| L | TRP277 |
| site_id | AF9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL K 403 |
| Chain | Residue |
| K | MET273 |
| K | TRP277 |
| K | HOH504 |
| K | HOH516 |
| L | HIS198 |
| site_id | AG1 |
| Number of Residues | 7 |
| Details | binding site for residue EDO K 404 |
| Chain | Residue |
| K | ARG283 |
| K | ASP286 |
| K | HOH508 |
| K | HOH569 |
| K | HOH573 |
| K | HOH667 |
| L | VAL300 |
| site_id | AG2 |
| Number of Residues | 8 |
| Details | binding site for residue N2P L 401 |
| Chain | Residue |
| K | TRP277 |
| L | TYR54 |
| L | GLU132 |
| L | CYS158 |
| L | ALA183 |
| L | GLU187 |
| L | HOH560 |
| L | HOH596 |
| site_id | AG3 |
| Number of Residues | 5 |
| Details | binding site for residue PEG L 402 |
| Chain | Residue |
| L | LYS84 |
| L | ASP112 |
| L | GLY113 |
| L | THR114 |
| L | HOH564 |
| site_id | AG4 |
| Number of Residues | 8 |
| Details | binding site for residue EDO L 403 |
| Chain | Residue |
| I | HOH543 |
| K | VAL300 |
| L | ARG283 |
| L | PRO285 |
| L | ASP286 |
| L | HOH528 |
| L | HOH539 |
| L | HOH559 |
| site_id | AG5 |
| Number of Residues | 8 |
| Details | binding site for residue N2P M 401 |
| Chain | Residue |
| M | GLU48 |
| M | TYR54 |
| M | GLU132 |
| M | CYS158 |
| M | ALA183 |
| M | GLU187 |
| M | HOH550 |
| M | HOH553 |
| site_id | AG6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL M 402 |
| Chain | Residue |
| M | ILE193 |
| M | SER195 |
| M | HIS198 |
| M | HOH503 |
| M | HOH504 |
| M | HOH608 |
| N | MET273 |
| site_id | AG7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL M 403 |
| Chain | Residue |
| M | MET273 |
| M | TRP277 |
| M | HOH515 |
| M | HOH517 |
| N | HIS198 |
| site_id | AG8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL M 404 |
| Chain | Residue |
| M | SER23 |
| M | THR75 |
| M | ARG78 |
| M | HOH519 |
| M | HOH535 |
| site_id | AG9 |
| Number of Residues | 9 |
| Details | binding site for residue N2P N 401 |
| Chain | Residue |
| M | TRP277 |
| N | TYR54 |
| N | GLU132 |
| N | CYS158 |
| N | TRP159 |
| N | ALA183 |
| N | GLU187 |
| N | HOH517 |
| N | HOH575 |
| site_id | AH1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL N 402 |
| Chain | Residue |
| N | SER23 |
| N | PRO74 |
| N | THR75 |
| N | ARG78 |
| N | HOH616 |
| site_id | AH2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO N 403 |
| Chain | Residue |
| K | HOH512 |
| K | HOH667 |
| N | ARG283 |
| N | PRO285 |
| N | ASP286 |
| N | HOH548 |
| N | HOH669 |
| site_id | AH3 |
| Number of Residues | 9 |
| Details | binding site for residue N2P O 401 |
| Chain | Residue |
| O | TYR54 |
| O | GLU132 |
| O | CYS158 |
| O | ALA183 |
| O | ILE184 |
| O | GLU187 |
| O | HOH537 |
| O | HOH571 |
| P | TRP277 |
| site_id | AH4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL O 402 |
| Chain | Residue |
| O | SER195 |
| O | HIS198 |
| O | HOH505 |
| O | HOH579 |
| P | TRP277 |
| P | HOH416 |
| site_id | AH5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL O 403 |
| Chain | Residue |
| O | VAL22 |
| O | SER23 |
| O | THR75 |
| O | ARG78 |
