Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue CL A 401 |
| Chain | Residue |
| A | GLY48 |
| A | LYS49 |
| A | TYR50 |
| A | SER51 |
| A | EDO416 |
| A | HOH635 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 402 |
| Chain | Residue |
| A | HIS148 |
| A | ALA315 |
| A | HOH555 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 403 |
| Chain | Residue |
| A | ASP156 |
| A | LYS158 |
| A | SER194 |
| A | 5Y4421 |
| A | HOH577 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | ARG155 |
| A | GLU180 |
| A | GLN186 |
| A | TYR188 |
| A | ASN189 |
| A | ARG275 |
| A | EDO412 |
| A | HOH551 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 405 |
| Chain | Residue |
| A | ARG306 |
| A | TYR307 |
| A | ASP308 |
| A | HOH525 |
| A | HOH571 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 406 |
| Chain | Residue |
| A | LYS158 |
| A | HIS160 |
| A | SER194 |
| A | PHE197 |
| A | HOH654 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 407 |
| Chain | Residue |
| A | ARG21 |
| A | TYR131 |
| A | ASP132 |
| A | PHE135 |
| A | ARG169 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 408 |
| Chain | Residue |
| A | ASP37 |
| A | TYR39 |
| A | GLN40 |
| A | HOH570 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 409 |
| Chain | Residue |
| A | LEU203 |
| A | ASN238 |
| A | GLU252 |
| A | ASP256 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 410 |
| Chain | Residue |
| A | PHE232 |
| A | VAL248 |
| A | HOH515 |
| A | HOH584 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 411 |
| Chain | Residue |
| A | PRO6 |
| A | GLU114 |
| A | HOH524 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 412 |
| Chain | Residue |
| A | ARG80 |
| A | ARG155 |
| A | LEU178 |
| A | ASN189 |
| A | EDO404 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 413 |
| Chain | Residue |
| A | ASN16 |
| A | THR17 |
| A | TRP24 |
| A | GLU167 |
| A | HIS183 |
| A | HOH601 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 414 |
| Chain | Residue |
| A | ASP25 |
| A | TYR26 |
| A | GLU27 |
| site_id | AD6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 415 |
| Chain | Residue |
| A | ASN118 |
| A | ASP120 |
| A | PHE121 |
| A | PRO159 |
| A | HIS160 |
| A | VAL162 |
| A | MET163 |
| site_id | AD7 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 416 |
| Chain | Residue |
| A | TYR50 |
| A | LYS77 |
| A | ASP175 |
| A | GLY177 |
| A | LEU178 |
| A | CL401 |
| A | 5Y4421 |
| A | HOH504 |
| A | HOH577 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 417 |
| Chain | Residue |
| A | GLN36 |
| A | ALA110 |
| A | GLU320 |
| A | HOH533 |
| A | HOH570 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 418 |
| Chain | Residue |
| A | PHE54 |
| A | LYS303 |
| A | GLU317 |
| A | HIS321 |
| A | HOH529 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 419 |
| Chain | Residue |
| A | GLY34 |
| A | ASN35 |
| A | GLN36 |
| A | VAL101 |
| A | LYS102 |
| A | HOH538 |
| site_id | AE2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 420 |
| Chain | Residue |
| A | THR13 |
| A | SER287 |
| A | ARG10 |
| site_id | AE3 |
| Number of Residues | 15 |
| Details | binding site for residue 5Y4 A 421 |
| Chain | Residue |
| A | SER51 |
| A | VAL53 |
| A | VAL66 |
| A | LYS68 |
| A | ILE95 |
| A | PHE113 |
| A | GLU114 |
| A | VAL116 |
| A | ASN161 |
| A | MET163 |
| A | ASP175 |
| A | EDO403 |
| A | EDO416 |
| A | HOH522 |
| A | HOH619 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnnek..........VVVK |
| Chain | Residue | Details |
| A | LEU45-LYS68 | |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI |
| Chain | Residue | Details |
| A | ILE152-ILE164 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | Region: {"description":"Interaction with beta subunit","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor"} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
