5H8F
Structure of the apo human GluN1/GluN2A LBD
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 301 |
| Chain | Residue |
| A | ILE238 |
| A | PHE239 |
| A | ALA240 |
| A | THR241 |
| A | HOH437 |
| B | HIS273 |
| B | GLU279 |
| B | HOH460 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue GLU A 302 |
| Chain | Residue |
| A | SER113 |
| A | THR115 |
| A | ARG120 |
| A | GLY171 |
| A | SER172 |
| A | THR173 |
| A | TYR213 |
| A | ASP214 |
| A | HOH455 |
| A | HOH521 |
| A | HIS87 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 301 |
| Chain | Residue |
| B | THR28 |
| B | CYS29 |
| B | LYS42 |
| B | HOH530 |
| B | HOH542 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 302 |
| Chain | Residue |
| B | THR34 |
| B | VAL35 |
| B | THR284 |
| B | TRP285 |
| B | HOH432 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 303 |
| Chain | Residue |
| B | THR34 |
| B | ASP38 |
| B | PRO39 |
| B | LYS41 |
| B | ASP70 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 304 |
| Chain | Residue |
| B | ASP120 |
| B | ARG256 |
| B | SER259 |
| B | PRO260 |
| B | TRP261 |
| B | HOH402 |
| B | HOH516 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 305 |
| Chain | Residue |
| A | ASP259 |
| B | ALA133 |
| B | ILE136 |
| B | GLU137 |
| B | PHE138 |
| B | LYS257 |
| B | HOH422 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue GLY B 306 |
| Chain | Residue |
| B | PHE93 |
| B | PRO125 |
| B | LEU126 |
| B | THR127 |
| B | ARG132 |
| B | SER180 |
| B | SER181 |
| B | ASP225 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0007744|PDB:5H8F, ECO:0007744|PDB:5H8H, ECO:0007744|PDB:5H8N, ECO:0007744|PDB:5H8Q, ECO:0007744|PDB:5I2K, ECO:0007744|PDB:5I2N, ECO:0007744|PDB:5KCJ, ECO:0007744|PDB:5KDT, ECO:0007744|PDB:5TP9, ECO:0007744|PDB:5TPA |
| Chain | Residue | Details |
| B | PRO125 | |
| A | THR115 | |
| A | ARG120 | |
| A | SER172 | |
| A | THR173 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:36959261, ECO:0007744|PDB:5H8F, ECO:0007744|PDB:5H8H, ECO:0007744|PDB:5H8N, ECO:0007744|PDB:5H8Q, ECO:0007744|PDB:5I2K, ECO:0007744|PDB:5I2N, ECO:0007744|PDB:5KCJ, ECO:0007744|PDB:5KDT, ECO:0007744|PDB:5TP9, ECO:0007744|PDB:5TPA, ECO:0007744|PDB:7YFF |
| Chain | Residue | Details |
| B | THR127 | |
| B | SER181 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:36309015, ECO:0000269|PubMed:36959261, ECO:0000312|PDB:8E96, ECO:0007744|PDB:5H8F, ECO:0007744|PDB:5H8H, ECO:0007744|PDB:5H8N, ECO:0007744|PDB:5H8Q, ECO:0007744|PDB:5I2K, ECO:0007744|PDB:5I2N, ECO:0007744|PDB:5KCJ, ECO:0007744|PDB:5KDT, ECO:0007744|PDB:5TP9, ECO:0007744|PDB:5TPA, ECO:0007744|PDB:7YFR |
| Chain | Residue | Details |
| B | ARG132 | |
| A | ASN46 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:36309015, ECO:0000269|PubMed:36959261, ECO:0000312|PDB:8E96, ECO:0007744|PDB:5H8F, ECO:0007744|PDB:5H8H, ECO:0007744|PDB:5H8N, ECO:0007744|PDB:5H8Q, ECO:0007744|PDB:5I2K, ECO:0007744|PDB:5I2N, ECO:0007744|PDB:5KCJ, ECO:0007744|PDB:5KDT, ECO:0007744|PDB:5TP9, ECO:0007744|PDB:5TPA, ECO:0007744|PDB:7YFF |
| Chain | Residue | Details |
| B | ASP225 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN49 | |
| B | ASN100 | |
| B | ASN167 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:34186027, ECO:0000269|PubMed:36309015, ECO:0000269|PubMed:36959261, ECO:0000312|PDB:8E93, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E97, ECO:0000312|PDB:8E98, ECO:0007744|PDB:7EOQ, ECO:0007744|PDB:7YFR |
| Chain | Residue | Details |
| B | ASN80 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:34186027, ECO:0000269|PubMed:36309015, ECO:0000312|PDB:8E92, ECO:0000312|PDB:8E93, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E96, ECO:0000312|PDB:8E97, ECO:0000312|PDB:8E98, ECO:0000312|PDB:8E99, ECO:0007744|PDB:7EOQ |
| Chain | Residue | Details |
| B | ASN264 |
