5H8F

Structure of the apo human GluN1/GluN2A LBD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue GOL A 301

Chain	Residue
A	ILE238
A	PHE239
A	ALA240
A	THR241
A	HOH437
B	HIS273
B	GLU279
B	HOH460

---

site_id	AC2
Number of Residues	11
Details	binding site for residue GLU A 302

Chain	Residue
A	SER113
A	THR115
A	ARG120
A	GLY171
A	SER172
A	THR173
A	TYR213
A	ASP214
A	HOH455
A	HOH521
A	HIS87

---

site_id	AC3
Number of Residues	5
Details	binding site for residue GOL B 301

Chain	Residue
B	THR28
B	CYS29
B	LYS42
B	HOH530
B	HOH542

---

site_id	AC4
Number of Residues	5
Details	binding site for residue GOL B 302

Chain	Residue
B	THR34
B	VAL35
B	THR284
B	TRP285
B	HOH432

---

site_id	AC5
Number of Residues	5
Details	binding site for residue GOL B 303

Chain	Residue
B	THR34
B	ASP38
B	PRO39
B	LYS41
B	ASP70

---

site_id	AC6
Number of Residues	7
Details	binding site for residue GOL B 304

Chain	Residue
B	ASP120
B	ARG256
B	SER259
B	PRO260
B	TRP261
B	HOH402
B	HOH516

---

site_id	AC7
Number of Residues	7
Details	binding site for residue GOL B 305

Chain	Residue
A	ASP259
B	ALA133
B	ILE136
B	GLU137
B	PHE138
B	LYS257
B	HOH422

---

site_id	AC8
Number of Residues	8
Details	binding site for residue GLY B 306

Chain	Residue
B	PHE93
B	PRO125
B	LEU126
B	THR127
B	ARG132
B	SER180
B	SER181
B	ASP225

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26875626","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26919761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28105280","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5H8F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KCJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TP9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26875626","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26919761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28105280","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5H8F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KCJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TP9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"34186027","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EOQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EOT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26875626","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26919761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28105280","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36959261","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5H8F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KCJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TP9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YFF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26875626","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26919761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28105280","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36309015","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36959261","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E96","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"5H8F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KCJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TP9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YFR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26875626","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26919761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28105280","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36309015","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36959261","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E96","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"5H8F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KCJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TP9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YFF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"34186027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36309015","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36959261","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E93","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E94","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E97","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E98","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7EOQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YFR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"34186027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36309015","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E92","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E93","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E94","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E96","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E97","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E98","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E99","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7EOQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---