5H5K
ATP and CMP bound Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004798 | molecular_function | thymidylate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006227 | biological_process | dUDP biosynthetic process |
| A | 0006233 | biological_process | dTDP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| B | 0004798 | molecular_function | thymidylate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006227 | biological_process | dUDP biosynthetic process |
| B | 0006233 | biological_process | dTDP biosynthetic process |
| B | 0006235 | biological_process | dTTP biosynthetic process |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 201 |
| Chain | Residue |
| A | THR14 |
| A | ATP202 |
| A | C5P206 |
| A | HOH308 |
| A | HOH314 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | binding site for residue ATP A 202 |
| Chain | Residue |
| A | GLY12 |
| A | LYS13 |
| A | THR14 |
| A | THR15 |
| A | ARG90 |
| A | ARG139 |
| A | ARG145 |
| A | GLY176 |
| A | GLU177 |
| A | GLU178 |
| A | MG201 |
| A | C5P206 |
| A | HOH308 |
| A | HOH309 |
| A | ILE8 |
| A | ASP9 |
| A | GLY10 |
| A | SER11 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 203 |
| Chain | Residue |
| A | VAL31 |
| A | LYS84 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 204 |
| Chain | Residue |
| A | ARG58 |
| B | GLU115 |
| B | ARG119 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 205 |
| Chain | Residue |
| A | ARG119 |
| B | ARG58 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residue C5P A 206 |
| Chain | Residue |
| A | ASP9 |
| A | ARG47 |
| A | PHE64 |
| A | ARG90 |
| A | SER94 |
| A | THR95 |
| A | TYR98 |
| A | GLN99 |
| A | ARG145 |
| A | MG201 |
| A | ATP202 |
| A | HOH301 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue MG B 201 |
| Chain | Residue |
| B | THR14 |
| B | ATP202 |
| B | C5P203 |
| site_id | AC8 |
| Number of Residues | 17 |
| Details | binding site for residue ATP B 202 |
| Chain | Residue |
| B | ILE8 |
| B | ASP9 |
| B | GLY10 |
| B | SER11 |
| B | GLY12 |
| B | LYS13 |
| B | THR14 |
| B | THR15 |
| B | ARG90 |
| B | ARG139 |
| B | GLY176 |
| B | GLU177 |
| B | GLU178 |
| B | MG201 |
| B | C5P203 |
| B | HOH314 |
| B | HOH322 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | binding site for residue C5P B 203 |
| Chain | Residue |
| B | ASP9 |
| B | ARG47 |
| B | PHE64 |
| B | ARG90 |
| B | SER94 |
| B | THR95 |
| B | TYR98 |
| B | GLN99 |
| B | MG201 |
| B | ATP202 |
| B | HOH302 |
Functional Information from PROSITE/UniProt
| site_id | PS01331 |
| Number of Residues | 13 |
| Details | THYMIDYLATE_KINASE Thymidylate kinase signature. ILDRFvlSTiAYQ |
| Chain | Residue | Details |
| A | ILE87-GLN99 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY7 | |
| B | GLY7 |
