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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5H1K

Crystal structure of WD40 repeat domains of Gemin5 in complex with 13-nt U4 snRNA fragment

Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. CATSsdDgTVKIWDV
ChainResidueDetails
ACYS82-VAL96
ALEU395-THR409
ALEU655-ALA669
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues84
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues82
DetailsRepeat: {"description":"WD 2"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues78
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues82
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues80
DetailsRepeat: {"description":"WD 7"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues80
DetailsRepeat: {"description":"WD 8"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues80
DetailsRepeat: {"description":"WD 10"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues92
DetailsRepeat: {"description":"WD 11"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues80
DetailsRepeat: {"description":"WD 12"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues80
DetailsRepeat: {"description":"WD 13"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsRegion: {"description":"Interaction with U4 snRNA","evidences":[{"source":"PubMed","id":"27834343","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881600","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5GXI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H1K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H1L","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues4
DetailsSite: {"description":"Interaction with U4 snRNA","evidences":[{"source":"PubMed","id":"27834343","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881600","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5GXI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H1K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H1L","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues6
DetailsSite: {"description":"Interaction with U4 snRNA","evidences":[{"source":"PubMed","id":"27834343","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5H1K","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsSite: {"description":"Interaction with U4 snRNA","evidences":[{"source":"PubMed","id":"27834343","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881600","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GXI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H1K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H1L","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues8
DetailsSite: {"description":"Interaction with U4 snRNA","evidences":[{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5H1K","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsSite: {"description":"Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA molecules","evidences":[{"source":"PubMed","id":"27834343","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2016","submissionDatabase":"PDB data bank","title":"Crystal structure of Gemin5 WD40 repeats in complex with m7GpppG.","authors":["Chao X.","Tempel W.","Bian C.","He H.","Cerovina T.","Bountra C.","Arrowsmith C.H.","Edwards A.M.","Min J."]}},{"source":"PDB","id":"5H1M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TEF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsSite: {"description":"Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA molecules","evidences":[{"source":"PubMed","id":"27834343","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2016","submissionDatabase":"PDB data bank","title":"Crystal structure of Gemin5 WD40 repeats in complex with m7GpppG.","authors":["Chao X.","Tempel W.","Bian C.","He H.","Cerovina T.","Bountra C.","Arrowsmith C.H.","Edwards A.M.","Min J."]}},{"source":"PDB","id":"5H1K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TEF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsSite: {"description":"Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA molecules","evidences":[{"source":"PubMed","id":"27834343","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2016","submissionDatabase":"PDB data bank","title":"Crystal structure of Gemin5 WD40 repeats in complex with m7GpppG.","authors":["Chao X.","Tempel W.","Bian C.","He H.","Cerovina T.","Bountra C.","Arrowsmith C.H.","Edwards A.M.","Min J."]}},{"source":"PDB","id":"5H1K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H1M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TEF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues2
DetailsSite: {"description":"Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA molecules","evidences":[{"source":"PubMed","id":"27834343","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881600","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H1K","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues123
DetailsRegion: {"description":"Important for interaction with U1 snRNA","evidences":[{"source":"PubMed","id":"19377484","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

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