5H13

EED in complex with PRC2 allosteric inhibitor EED396

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016571	biological_process	histone methylation
A	0035098	cellular_component	ESC/E(Z) complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue GOL A 501

Chain	Residue
A	CYS330
A	GLY354
A	LYS400

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site_id	AC2
Number of Residues	8
Details	binding site for residue PR A 502

Chain	Residue
A	HOH635
A	HOH635
A	GLU392
A	GLU392
A	GLU394
A	GLU394
A	HOH608
A	HOH608

---

site_id	AC3
Number of Residues	9
Details	binding site for residue LQA A 503

Chain	Residue
A	PRO95
A	PHE97
A	ASN146
A	TYR148
A	ASN194
A	GLU276
A	TYR365
A	ARG367
A	ARG414

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Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSVskDhALRLWNI

Chain	Residue	Details
A	LEU206-ILE220

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	43
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	40
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	41
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	37
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	40
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"20974918","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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