5H0Z
Crystal structure of P113A mutated human transthyretin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001523 | biological_process | retinoid metabolic process |
| A | 0003105 | biological_process | negative regulation of glomerular filtration |
| A | 0005179 | molecular_function | hormone activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006144 | biological_process | purine nucleobase metabolic process |
| A | 0007603 | biological_process | phototransduction, visible light |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0042562 | molecular_function | hormone binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0140313 | molecular_function | molecular sequestering activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 201 |
| Chain | Residue |
| A | SER10 |
| A | HIS56 |
| A | GLY57 |
| A | ARG104 |
| A | HOH309 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 202 |
| Chain | Residue |
| A | LYS76 |
| A | LYS80 |
Functional Information from PROSITE/UniProt
| site_id | PS00768 |
| Number of Residues | 16 |
| Details | TRANSTHYRETIN_1 Transthyretin signature 1. KVLDavrGsPAinVaV |
| Chain | Residue | Details |
| A | LYS15-VAL30 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11418763, ECO:0007744|PDB:1ICT |
| Chain | Residue | Details |
| A | LYS15 | |
| A | GLU54 | |
| A | SER117 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: 4-carboxyglutamate; in a patient with Moyamoya disease => ECO:0000269|PubMed:18221012 |
| Chain | Residue | Details |
| A | GLU42 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P02767 |
| Chain | Residue | Details |
| A | SER52 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19167329 |
| Chain | Residue | Details |
| A | ASN98 |
