5GV2

Crystal structure of Arginine-bound CASTOR1 from Homo sapiens

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0031669	biological_process	cellular response to nutrient levels
A	0034198	biological_process	cellular response to amino acid starvation
A	0034618	molecular_function	arginine binding
A	0042802	molecular_function	identical protein binding
A	0061700	cellular_component	GATOR2 complex
A	0085020	biological_process	protein K6-linked ubiquitination
A	0140299	molecular_function	molecular sensor activity
A	0140311	molecular_function	protein sequestering activity
A	1903577	biological_process	cellular response to L-arginine
A	1904262	biological_process	negative regulation of TORC1 signaling
A	1904263	biological_process	positive regulation of TORC1 signaling
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0031669	biological_process	cellular response to nutrient levels
C	0034198	biological_process	cellular response to amino acid starvation
C	0034618	molecular_function	arginine binding
C	0042802	molecular_function	identical protein binding
C	0061700	cellular_component	GATOR2 complex
C	0085020	biological_process	protein K6-linked ubiquitination
C	0140299	molecular_function	molecular sensor activity
C	0140311	molecular_function	protein sequestering activity
C	1903577	biological_process	cellular response to L-arginine
C	1904262	biological_process	negative regulation of TORC1 signaling
C	1904263	biological_process	positive regulation of TORC1 signaling

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MG C 501

Chain	Residue
A	HIS108
A	HIS135
C	HIS108
C	HIS135

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site_id	AC2
Number of Residues	16
Details	binding site for residue ARG A 401

Chain	Residue
A	CYS278
A	GLY279
A	ILE280
A	VAL281
A	SER299
A	THR300
A	PHE301
A	PHE303
A	ASP304
A	HOH538
A	HOH547
A	SER111
A	VAL112
A	LEU273
A	GLY274
A	GLU277

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	132
Details	Domain: {"description":"ACT 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	122
Details	Domain: {"description":"ACT 2"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27487210","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5I2C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKB/AKT1","evidences":[{"source":"PubMed","id":"33594058","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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