5GSN
Tmm in complex with methimazole
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004497 | molecular_function | monooxygenase activity |
A | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
A | 0050661 | molecular_function | NADP binding |
B | 0004497 | molecular_function | monooxygenase activity |
B | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
B | 0050661 | molecular_function | NADP binding |
C | 0004497 | molecular_function | monooxygenase activity |
C | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
C | 0050660 | molecular_function | flavin adenine dinucleotide binding |
C | 0050661 | molecular_function | NADP binding |
D | 0004497 | molecular_function | monooxygenase activity |
D | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
D | 0050660 | molecular_function | flavin adenine dinucleotide binding |
D | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 25 |
Details | binding site for residue NAP A 501 |
Chain | Residue |
A | ASN73 |
A | SER208 |
A | ARG229 |
A | SER230 |
A | CYS271 |
A | THR272 |
A | GLY273 |
A | ASN291 |
A | ASP317 |
A | GLN318 |
A | TRP319 |
A | PHE165 |
A | TRP401 |
A | MMZ503 |
A | HOH626 |
A | HOH648 |
A | HOH649 |
A | HOH697 |
A | ASN169 |
A | PRO171 |
A | TYR173 |
A | MET203 |
A | ALA205 |
A | SER206 |
A | SER207 |
site_id | AC2 |
Number of Residues | 31 |
Details | binding site for residue FAD A 502 |
Chain | Residue |
A | GLY9 |
A | GLY11 |
A | PRO12 |
A | SER13 |
A | PHE37 |
A | GLU38 |
A | LYS39 |
A | GLN40 |
A | GLY45 |
A | LEU46 |
A | TRP47 |
A | HIS63 |
A | SER65 |
A | SER72 |
A | ASN73 |
A | PRO125 |
A | VAL126 |
A | ALA161 |
A | SER162 |
A | PHE165 |
A | PHE280 |
A | GLN318 |
A | THR321 |
A | PHE325 |
A | MMZ503 |
A | HOH601 |
A | HOH616 |
A | HOH643 |
A | HOH658 |
A | HOH665 |
A | HOH681 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue MMZ A 503 |
Chain | Residue |
A | ASN73 |
A | SER207 |
A | SER208 |
A | NAP501 |
A | FAD502 |
site_id | AC4 |
Number of Residues | 22 |
Details | binding site for residue NAP B 501 |
Chain | Residue |
B | ASN73 |
B | PHE165 |
B | ASN169 |
B | PRO171 |
B | TYR173 |
B | MET203 |
B | ALA205 |
B | SER206 |
B | SER207 |
B | SER208 |
B | ARG229 |
B | SER230 |
B | CYS271 |
B | THR272 |
B | GLY273 |
B | TYR274 |
B | ASP317 |
B | GLN318 |
B | FAD502 |
B | HOH608 |
B | HOH636 |
B | HOH730 |
site_id | AC5 |
Number of Residues | 31 |
Details | binding site for residue FAD B 502 |
Chain | Residue |
B | VAL126 |
B | ALA161 |
B | SER162 |
B | GLY163 |
B | PHE165 |
B | PHE280 |
B | GLN318 |
B | THR321 |
B | PHE322 |
B | NAP501 |
B | HOH612 |
B | HOH639 |
B | HOH643 |
B | HOH665 |
B | HOH736 |
B | GLY9 |
B | GLY11 |
B | PRO12 |
B | SER13 |
B | PHE37 |
B | GLU38 |
B | LYS39 |
B | GLN40 |
B | GLY45 |
B | LEU46 |
B | TRP47 |
B | HIS63 |
B | SER65 |
B | SER72 |
B | ASN73 |
B | PRO125 |
site_id | AC6 |
Number of Residues | 26 |
Details | binding site for residue NAP C 501 |
Chain | Residue |
C | ASN73 |
C | PHE165 |
C | ASN169 |
C | PRO171 |
C | TYR173 |
C | MET203 |
C | ALA205 |
C | SER206 |
C | SER207 |
C | SER208 |
C | ARG229 |
C | SER230 |
C | CYS271 |
C | THR272 |
C | GLY273 |
C | TYR274 |
C | ASN291 |
C | ASP317 |
C | GLN318 |
C | THR321 |
C | FAD502 |
C | MMZ503 |
C | HOH672 |
C | HOH683 |
C | HOH701 |
C | HOH749 |
site_id | AC7 |
Number of Residues | 35 |
Details | binding site for residue FAD C 502 |
Chain | Residue |
C | GLY9 |
C | GLY11 |
C | PRO12 |
C | SER13 |
C | PHE37 |
C | GLU38 |
C | LYS39 |
C | GLN40 |
C | GLY45 |
C | LEU46 |
C | TRP47 |
C | HIS63 |
C | SER65 |
C | SER72 |
C | ASN73 |
C | LEU79 |
C | PRO125 |
C | VAL126 |
C | ALA161 |
C | SER162 |
C | GLY163 |
C | PHE165 |
C | PHE280 |
C | GLN318 |
C | THR321 |
C | PHE325 |
C | NAP501 |
C | MMZ503 |
C | HOH608 |
C | HOH613 |
C | HOH645 |
C | HOH659 |
C | HOH674 |
C | HOH696 |
C | HOH727 |
site_id | AC8 |
Number of Residues | 4 |
Details | binding site for residue MMZ C 503 |
Chain | Residue |
C | ASN73 |
C | SER208 |
C | NAP501 |
C | FAD502 |
site_id | AC9 |
Number of Residues | 24 |
Details | binding site for residue NAP D 501 |
Chain | Residue |
D | TYR67 |
D | ASN73 |
D | PHE165 |
D | ASN169 |
D | PRO171 |
D | TYR173 |
D | MET203 |
D | ALA205 |
D | SER206 |
D | SER207 |
D | SER208 |
D | ARG229 |
D | SER230 |
D | CYS271 |
D | THR272 |
D | ASP317 |
D | GLN318 |
D | FAD502 |
D | HOH606 |
D | HOH648 |
D | HOH654 |
D | HOH672 |
D | HOH694 |
D | HOH713 |
site_id | AD1 |
Number of Residues | 31 |
Details | binding site for residue FAD D 502 |
Chain | Residue |
D | GLY9 |
D | GLY11 |
D | PRO12 |
D | SER13 |
D | GLU38 |
D | LYS39 |
D | GLN40 |
D | GLY45 |
D | LEU46 |
D | TRP47 |
D | HIS63 |
D | MET66 |
D | SER72 |
D | ASN73 |
D | LEU79 |
D | VAL126 |
D | ALA161 |
D | SER162 |
D | PHE165 |
D | PHE280 |
D | GLN318 |
D | THR321 |
D | PHE325 |
D | NAP501 |
D | HOH611 |
D | HOH625 |
D | HOH651 |
D | HOH675 |
D | HOH681 |
D | HOH698 |
D | HOH713 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 52 |
Details | BINDING: BINDING => ECO:0000269|PubMed:27997715, ECO:0007744|PDB:5GSN, ECO:0007744|PDB:5IPY, ECO:0007744|PDB:5IQ1, ECO:0007744|PDB:5IQ4 |
Chain | Residue | Details |
A | SER13 | |
A | SER208 | |
A | ARG229 | |
A | GLN318 | |
A | THR321 | |
B | SER13 | |
B | GLU38 | |
B | GLN40 | |
B | LEU46 | |
B | TRP47 | |
B | HIS63 | |
A | GLU38 | |
B | VAL126 | |
B | TYR173 | |
B | SER206 | |
B | SER208 | |
B | ARG229 | |
B | GLN318 | |
B | THR321 | |
C | SER13 | |
C | GLU38 | |
C | GLN40 | |
A | GLN40 | |
C | LEU46 | |
C | TRP47 | |
C | HIS63 | |
C | VAL126 | |
C | TYR173 | |
C | SER206 | |
C | SER208 | |
C | ARG229 | |
C | GLN318 | |
C | THR321 | |
A | LEU46 | |
D | SER13 | |
D | GLU38 | |
D | GLN40 | |
D | LEU46 | |
D | TRP47 | |
D | HIS63 | |
D | VAL126 | |
D | TYR173 | |
D | SER206 | |
D | SER208 | |
A | TRP47 | |
D | ARG229 | |
D | GLN318 | |
D | THR321 | |
A | HIS63 | |
A | VAL126 | |
A | TYR173 | |
A | SER206 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:27997715, ECO:0007744|PDB:5IPY, ECO:0007744|PDB:5IQ1 |
Chain | Residue | Details |
A | TRP71 | |
A | ARG413 | |
B | TRP71 | |
B | ARG413 | |
C | TRP71 | |
C | ARG413 | |
D | TRP71 | |
D | ARG413 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:27997715, ECO:0007744|PDB:5IPY, ECO:0007744|PDB:5IQ1, ECO:0007744|PDB:5IQ4 |
Chain | Residue | Details |
A | ASN73 | |
B | ASN73 | |
C | ASN73 | |
D | ASN73 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:27997715, ECO:0007744|PDB:5GSN, ECO:0007744|PDB:5IPY, ECO:0007744|PDB:5IQ4 |
Chain | Residue | Details |
A | ALA205 | |
B | ALA205 | |
C | ALA205 | |
D | ALA205 |