5GSN
Tmm in complex with methimazole
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016709 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| A | 0034899 | molecular_function | trimethylamine monooxygenase activity |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0050661 | molecular_function | NADP binding |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016709 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| B | 0034899 | molecular_function | trimethylamine monooxygenase activity |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0050661 | molecular_function | NADP binding |
| C | 0004497 | molecular_function | monooxygenase activity |
| C | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016709 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| C | 0034899 | molecular_function | trimethylamine monooxygenase activity |
| C | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| C | 0050661 | molecular_function | NADP binding |
| D | 0004497 | molecular_function | monooxygenase activity |
| D | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016709 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| D | 0034899 | molecular_function | trimethylamine monooxygenase activity |
| D | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| D | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | binding site for residue NAP A 501 |
| Chain | Residue |
| A | ASN73 |
| A | SER208 |
| A | ARG229 |
| A | SER230 |
| A | CYS271 |
| A | THR272 |
| A | GLY273 |
| A | ASN291 |
| A | ASP317 |
| A | GLN318 |
| A | TRP319 |
| A | PHE165 |
| A | TRP401 |
| A | MMZ503 |
| A | HOH626 |
| A | HOH648 |
| A | HOH649 |
| A | HOH697 |
| A | ASN169 |
| A | PRO171 |
| A | TYR173 |
| A | MET203 |
| A | ALA205 |
| A | SER206 |
| A | SER207 |
| site_id | AC2 |
| Number of Residues | 31 |
| Details | binding site for residue FAD A 502 |
| Chain | Residue |
| A | GLY9 |
| A | GLY11 |
| A | PRO12 |
| A | SER13 |
| A | PHE37 |
| A | GLU38 |
| A | LYS39 |
| A | GLN40 |
| A | GLY45 |
| A | LEU46 |
| A | TRP47 |
| A | HIS63 |
| A | SER65 |
| A | SER72 |
| A | ASN73 |
| A | PRO125 |
| A | VAL126 |
| A | ALA161 |
| A | SER162 |
| A | PHE165 |
| A | PHE280 |
| A | GLN318 |
| A | THR321 |
| A | PHE325 |
| A | MMZ503 |
| A | HOH601 |
| A | HOH616 |
| A | HOH643 |
| A | HOH658 |
| A | HOH665 |
| A | HOH681 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MMZ A 503 |
| Chain | Residue |
| A | ASN73 |
| A | SER207 |
| A | SER208 |
| A | NAP501 |
| A | FAD502 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | binding site for residue NAP B 501 |
| Chain | Residue |
| B | ASN73 |
| B | PHE165 |
| B | ASN169 |
| B | PRO171 |
| B | TYR173 |
| B | MET203 |
| B | ALA205 |
| B | SER206 |
| B | SER207 |
| B | SER208 |
| B | ARG229 |
| B | SER230 |
| B | CYS271 |
| B | THR272 |
| B | GLY273 |
| B | TYR274 |
| B | ASP317 |
| B | GLN318 |
| B | FAD502 |
| B | HOH608 |
| B | HOH636 |
| B | HOH730 |
| site_id | AC5 |
| Number of Residues | 31 |
| Details | binding site for residue FAD B 502 |
| Chain | Residue |
| B | VAL126 |
| B | ALA161 |
| B | SER162 |
| B | GLY163 |
| B | PHE165 |
| B | PHE280 |
| B | GLN318 |
| B | THR321 |
| B | PHE322 |
| B | NAP501 |
| B | HOH612 |
| B | HOH639 |
| B | HOH643 |
| B | HOH665 |
| B | HOH736 |
| B | GLY9 |
| B | GLY11 |
| B | PRO12 |
| B | SER13 |
| B | PHE37 |
| B | GLU38 |
| B | LYS39 |
| B | GLN40 |
| B | GLY45 |
| B | LEU46 |
| B | TRP47 |
| B | HIS63 |
| B | SER65 |
| B | SER72 |
| B | ASN73 |
| B | PRO125 |
| site_id | AC6 |
| Number of Residues | 26 |
| Details | binding site for residue NAP C 501 |
| Chain | Residue |
| C | ASN73 |
| C | PHE165 |
| C | ASN169 |
| C | PRO171 |
| C | TYR173 |
| C | MET203 |
| C | ALA205 |
| C | SER206 |
| C | SER207 |
| C | SER208 |
| C | ARG229 |
| C | SER230 |
| C | CYS271 |
| C | THR272 |
| C | GLY273 |
| C | TYR274 |
| C | ASN291 |
| C | ASP317 |
| C | GLN318 |
| C | THR321 |
| C | FAD502 |
| C | MMZ503 |
| C | HOH672 |
| C | HOH683 |
| C | HOH701 |
| C | HOH749 |
| site_id | AC7 |
| Number of Residues | 35 |
| Details | binding site for residue FAD C 502 |
| Chain | Residue |
| C | GLY9 |
| C | GLY11 |
| C | PRO12 |
| C | SER13 |
| C | PHE37 |
| C | GLU38 |
| C | LYS39 |
| C | GLN40 |
| C | GLY45 |
| C | LEU46 |
| C | TRP47 |
| C | HIS63 |
| C | SER65 |
| C | SER72 |
| C | ASN73 |
| C | LEU79 |
| C | PRO125 |
| C | VAL126 |
| C | ALA161 |
| C | SER162 |
| C | GLY163 |
| C | PHE165 |
| C | PHE280 |
| C | GLN318 |
| C | THR321 |
| C | PHE325 |
| C | NAP501 |
| C | MMZ503 |
| C | HOH608 |
| C | HOH613 |
| C | HOH645 |
| C | HOH659 |
| C | HOH674 |
| C | HOH696 |
| C | HOH727 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue MMZ C 503 |
| Chain | Residue |
| C | ASN73 |
| C | SER208 |
| C | NAP501 |
| C | FAD502 |
| site_id | AC9 |
| Number of Residues | 24 |
| Details | binding site for residue NAP D 501 |
| Chain | Residue |
| D | TYR67 |
| D | ASN73 |
| D | PHE165 |
| D | ASN169 |
| D | PRO171 |
| D | TYR173 |
| D | MET203 |
| D | ALA205 |
| D | SER206 |
| D | SER207 |
| D | SER208 |
| D | ARG229 |
| D | SER230 |
| D | CYS271 |
| D | THR272 |
| D | ASP317 |
| D | GLN318 |
| D | FAD502 |
| D | HOH606 |
| D | HOH648 |
| D | HOH654 |
| D | HOH672 |
| D | HOH694 |
| D | HOH713 |
| site_id | AD1 |
| Number of Residues | 31 |
| Details | binding site for residue FAD D 502 |
| Chain | Residue |
| D | GLY9 |
| D | GLY11 |
| D | PRO12 |
| D | SER13 |
| D | GLU38 |
| D | LYS39 |
| D | GLN40 |
| D | GLY45 |
| D | LEU46 |
| D | TRP47 |
| D | HIS63 |
| D | MET66 |
| D | SER72 |
| D | ASN73 |
| D | LEU79 |
| D | VAL126 |
| D | ALA161 |
| D | SER162 |
| D | PHE165 |
| D | PHE280 |
| D | GLN318 |
| D | THR321 |
| D | PHE325 |
| D | NAP501 |
| D | HOH611 |
| D | HOH625 |
| D | HOH651 |
| D | HOH675 |
| D | HOH681 |
| D | HOH698 |
| D | HOH713 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 52 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27997715","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IPY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IQ1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IQ4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27997715","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IPY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IQ1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27997715","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IPY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IQ1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IQ4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27997715","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IPY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IQ4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
