5GS5
Crystal structure of apo rat STING
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002218 | biological_process | activation of innate immune response |
| A | 0032481 | biological_process | positive regulation of type I interferon production |
| B | 0002218 | biological_process | activation of innate immune response |
| B | 0032481 | biological_process | positive regulation of type I interferon production |
| C | 0002218 | biological_process | activation of innate immune response |
| C | 0032481 | biological_process | positive regulation of type I interferon production |
| D | 0002218 | biological_process | activation of innate immune response |
| D | 0032481 | biological_process | positive regulation of type I interferon production |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue SO4 A 401 |
| Chain | Residue |
| A | GLN176 |
| D | ARG232 |
| D | HOH581 |
| A | ARG180 |
| A | ARG306 |
| A | HOH543 |
| A | HOH549 |
| D | GLY174 |
| D | GLN176 |
| D | ALA177 |
| D | ARG180 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | ARG180 |
| A | HOH512 |
| A | HOH541 |
| A | HOH549 |
| D | PRO173 |
| D | GLY174 |
| D | ARG232 |
| D | SER305 |
| D | ARG306 |
| D | HIS308 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 401 |
| Chain | Residue |
| B | ALA193 |
| B | ARG196 |
| B | ARG197 |
| B | ALA340 |
| B | HOH515 |
| B | HOH524 |
| C | ARG180 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue SO4 C 401 |
| Chain | Residue |
| B | GLN176 |
| B | ARG180 |
| B | ARG306 |
| B | HOH540 |
| C | GLY174 |
| C | GLN176 |
| C | ALA177 |
| C | ARG180 |
| C | ARG232 |
| C | HOH533 |
| C | HOH555 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 C 402 |
| Chain | Residue |
| B | ARG180 |
| C | PRO173 |
| C | GLY174 |
| C | ARG232 |
| C | ARG306 |
| C | HIS308 |
| C | HOH517 |
| C | HOH549 |
| C | HOH555 |
| C | HOH570 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 C 403 |
| Chain | Residue |
| A | GLN227 |
| A | HOH544 |
| C | HIS157 |
| C | TRP161 |
| C | HOH506 |
| C | HOH618 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 D 401 |
| Chain | Residue |
| A | ARG334 |
| D | ARG220 |
| D | ARG222 |
| D | HOH580 |
| D | HOH609 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 D 402 |
| Chain | Residue |
| A | GLN228 |
| A | THR230 |
| A | ARG232 |
| D | ARG232 |
| D | ALA233 |
| D | GLY234 |
| D | HOH512 |
| D | HOH546 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 D 403 |
| Chain | Residue |
| B | GLN227 |
| B | HOH578 |
| D | HIS157 |
| D | TRP161 |
| D | HOH502 |
| D | HOH532 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:26669264 |
| Chain | Residue | Details |
| A | SER162 | |
| B | SER162 | |
| C | SER162 | |
| D | SER162 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q3TBT3 |
| Chain | Residue | Details |
| A | GLY166 | |
| A | THR263 | |
| B | GLY166 | |
| B | THR263 | |
| C | GLY166 | |
| C | THR263 | |
| D | GLY166 | |
| D | THR263 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q86WV6 |
| Chain | Residue | Details |
| A | TYR167 | |
| A | ARG238 | |
| B | TYR167 | |
| B | ARG238 | |
| C | TYR167 | |
| C | ARG238 | |
| D | TYR167 | |
| D | ARG238 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q86WV6 |
| Chain | Residue | Details |
| A | SER241 | |
| B | SER241 | |
| C | SER241 | |
| D | SER241 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q3TBT3 |
| Chain | Residue | Details |
| A | LYS151 | |
| B | LYS151 | |
| C | LYS151 | |
| D | LYS151 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q86WV6 |
| Chain | Residue | Details |
| A | LYS236 | |
| B | LYS236 | |
| C | LYS236 | |
| D | LYS236 |
