5GS5

Crystal structure of apo rat STING

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002218	biological_process	activation of innate immune response
A	0032481	biological_process	positive regulation of type I interferon production
B	0002218	biological_process	activation of innate immune response
B	0032481	biological_process	positive regulation of type I interferon production
C	0002218	biological_process	activation of innate immune response
C	0032481	biological_process	positive regulation of type I interferon production
D	0002218	biological_process	activation of innate immune response
D	0032481	biological_process	positive regulation of type I interferon production

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue SO4 A 401

Chain	Residue
A	GLN176
D	ARG232
D	HOH581
A	ARG180
A	ARG306
A	HOH543
A	HOH549
D	GLY174
D	GLN176
D	ALA177
D	ARG180

---

site_id	AC2
Number of Residues	10
Details	binding site for residue SO4 A 402

Chain	Residue
A	ARG180
A	HOH512
A	HOH541
A	HOH549
D	PRO173
D	GLY174
D	ARG232
D	SER305
D	ARG306
D	HIS308

---

site_id	AC3
Number of Residues	7
Details	binding site for residue SO4 B 401

Chain	Residue
B	ALA193
B	ARG196
B	ARG197
B	ALA340
B	HOH515
B	HOH524
C	ARG180

---

site_id	AC4
Number of Residues	11
Details	binding site for residue SO4 C 401

Chain	Residue
B	GLN176
B	ARG180
B	ARG306
B	HOH540
C	GLY174
C	GLN176
C	ALA177
C	ARG180
C	ARG232
C	HOH533
C	HOH555

---

site_id	AC5
Number of Residues	10
Details	binding site for residue SO4 C 402

Chain	Residue
B	ARG180
C	PRO173
C	GLY174
C	ARG232
C	ARG306
C	HIS308
C	HOH517
C	HOH549
C	HOH555
C	HOH570

---

site_id	AC6
Number of Residues	6
Details	binding site for residue SO4 C 403

Chain	Residue
A	GLN227
A	HOH544
C	HIS157
C	TRP161
C	HOH506
C	HOH618

---

site_id	AC7
Number of Residues	5
Details	binding site for residue SO4 D 401

Chain	Residue
A	ARG334
D	ARG220
D	ARG222
D	HOH580
D	HOH609

---

site_id	AC8
Number of Residues	8
Details	binding site for residue SO4 D 402

Chain	Residue
A	GLN228
A	THR230
A	ARG232
D	ARG232
D	ALA233
D	GLY234
D	HOH512
D	HOH546

---

site_id	AC9
Number of Residues	6
Details	binding site for residue SO4 D 403

Chain	Residue
B	GLN227
B	HOH578
D	HIS157
D	TRP161
D	HOH502
D	HOH532

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26669264","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q3TBT3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q86WV6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q86WV6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q3TBT3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q86WV6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---