5GNM
Cytochrome P450 Vdh (CYP107BR1) L348M mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0020037 | molecular_function | heme binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047748 | molecular_function | cholestanetetraol 26-dehydrogenase activity |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| B | 0020037 | molecular_function | heme binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0047748 | molecular_function | cholestanetetraol 26-dehydrogenase activity |
| C | 0004497 | molecular_function | monooxygenase activity |
| C | 0005506 | molecular_function | iron ion binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| C | 0020037 | molecular_function | heme binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0047748 | molecular_function | cholestanetetraol 26-dehydrogenase activity |
| D | 0004497 | molecular_function | monooxygenase activity |
| D | 0005506 | molecular_function | iron ion binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| D | 0020037 | molecular_function | heme binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0047748 | molecular_function | cholestanetetraol 26-dehydrogenase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue HEM A 501 |
| Chain | Residue |
| A | PHE58 |
| A | THR241 |
| A | LEU244 |
| A | VAL283 |
| A | PRO287 |
| A | ARG289 |
| A | PHE339 |
| A | PHE340 |
| A | GLY341 |
| A | HIS345 |
| A | CYS347 |
| A | LYS65 |
| A | GLY349 |
| A | ALA353 |
| A | HOH623 |
| A | MET87 |
| A | HIS95 |
| A | ARG99 |
| A | LEU233 |
| A | ALA236 |
| A | GLY237 |
| A | THR240 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | binding site for residue HEM B 501 |
| Chain | Residue |
| B | PHE58 |
| B | LYS65 |
| B | MET87 |
| B | ILE88 |
| B | HIS95 |
| B | ARG99 |
| B | PHE106 |
| B | LEU233 |
| B | ALA236 |
| B | GLY237 |
| B | THR240 |
| B | THR241 |
| B | LEU244 |
| B | ALA286 |
| B | PRO287 |
| B | ARG289 |
| B | PHE339 |
| B | PHE340 |
| B | GLY341 |
| B | HIS345 |
| B | CYS347 |
| B | ALA353 |
| site_id | AC3 |
| Number of Residues | 23 |
| Details | binding site for residue HEM C 501 |
| Chain | Residue |
| C | PHE58 |
| C | LYS65 |
| C | MET87 |
| C | ILE88 |
| C | HIS95 |
| C | ARG99 |
| C | LEU233 |
| C | ALA236 |
| C | GLY237 |
| C | THR240 |
| C | THR241 |
| C | PRO282 |
| C | PRO287 |
| C | ARG289 |
| C | PHE339 |
| C | PHE340 |
| C | GLY341 |
| C | ILE344 |
| C | HIS345 |
| C | CYS347 |
| C | GLY349 |
| C | ALA353 |
| C | HOH604 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | binding site for residue HEM D 501 |
| Chain | Residue |
| D | PHE58 |
| D | LYS65 |
| D | MET87 |
| D | ILE88 |
| D | HIS95 |
| D | ARG99 |
| D | LEU233 |
| D | ALA236 |
| D | THR240 |
| D | THR241 |
| D | PRO282 |
| D | PRO287 |
| D | ARG289 |
| D | PHE339 |
| D | PHE340 |
| D | GLY341 |
| D | ILE344 |
| D | HIS345 |
| D | CYS347 |
| D | GLY349 |
| D | ALA353 |
| D | HOH626 |
Functional Information from PROSITE/UniProt
| site_id | PS00086 |
| Number of Residues | 10 |
| Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGhGIHFCMG |
| Chain | Residue | Details |
| A | PHE340-GLY349 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"UniProtKB","id":"P0A512","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
