5GM2
Crystal structure of methyltransferase TleD complexed with SAH and teleocidin A1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| D | 0008168 | molecular_function | methyltransferase activity |
| D | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| E | 0008168 | molecular_function | methyltransferase activity |
| E | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| F | 0008168 | molecular_function | methyltransferase activity |
| F | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| G | 0008168 | molecular_function | methyltransferase activity |
| G | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| H | 0008168 | molecular_function | methyltransferase activity |
| H | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| I | 0008168 | molecular_function | methyltransferase activity |
| I | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| J | 0008168 | molecular_function | methyltransferase activity |
| J | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| K | 0008168 | molecular_function | methyltransferase activity |
| K | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| L | 0008168 | molecular_function | methyltransferase activity |
| L | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| M | 0008168 | molecular_function | methyltransferase activity |
| M | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| N | 0008168 | molecular_function | methyltransferase activity |
| N | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| O | 0008168 | molecular_function | methyltransferase activity |
| O | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| P | 0008168 | molecular_function | methyltransferase activity |
| P | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| Q | 0008168 | molecular_function | methyltransferase activity |
| Q | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| R | 0008168 | molecular_function | methyltransferase activity |
| R | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue SAH A 301 |
| Chain | Residue |
| A | GLY85 |
| A | ALA136 |
| A | MET137 |
| A | ILE152 |
| A | SER154 |
| A | HIS157 |
| A | MET158 |
| A | HOH414 |
| B | VAL17 |
| B | TYR21 |
| B | VAL36 |
| A | CYS86 |
| B | HIS37 |
| A | GLY87 |
| A | THR91 |
| A | ALA107 |
| A | VAL108 |
| A | GLN112 |
| A | ALA134 |
| A | ASP135 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue TEX A 302 |
| Chain | Residue |
| A | GLU153 |
| A | CYS156 |
| A | HIS157 |
| A | GLU181 |
| A | SER182 |
| A | PHE196 |
| A | LEU232 |
| A | MET236 |
| A | LEU273 |
| B | TYR21 |
| B | TYR28 |
| B | LEU32 |
| B | VAL36 |
| B | HIS37 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | binding site for residue SAH B 301 |
| Chain | Residue |
| A | VAL17 |
| A | VAL36 |
| A | HIS37 |
| B | GLY85 |
| B | CYS86 |
| B | GLY87 |
| B | THR91 |
| B | ALA107 |
| B | VAL108 |
| B | GLN112 |
| B | ALA134 |
| B | ASP135 |
| B | ALA136 |
| B | ILE152 |
| B | GLU153 |
| B | SER154 |
| B | HIS157 |
| B | MET158 |
| B | HOH416 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | binding site for residue TEX B 302 |
| Chain | Residue |
| A | TYR21 |
| A | TYR28 |
| A | LEU32 |
| A | VAL36 |
| A | HIS37 |
| A | CYS38 |
| B | GLU153 |
| B | CYS156 |
| B | HIS157 |
| B | GLU181 |
| B | SER182 |
| B | PHE196 |
| B | LEU232 |
| B | THR235 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | binding site for residue SAH C 301 |
| Chain | Residue |
| C | GLY85 |
| C | CYS86 |
| C | GLY87 |
| C | ALA107 |
| C | VAL108 |
| C | GLN112 |
| C | ASP135 |
| C | ALA136 |
| C | ILE152 |
| C | HIS157 |
| D | VAL17 |
| D | TYR21 |
| D | VAL36 |
| D | HIS37 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | binding site for residue TEX C 302 |
| Chain | Residue |
| C | GLU153 |
| C | CYS156 |
| C | HIS157 |
| C | GLU181 |
| C | SER182 |
| C | PHE196 |
| C | LEU232 |
| C | THR235 |
| C | MET236 |
| D | TYR21 |
| D | TYR28 |
| D | LEU32 |
| D | VAL36 |
| D | HIS37 |
| site_id | AC7 |
| Number of Residues | 17 |
| Details | binding site for residue SAH D 301 |
| Chain | Residue |
| D | GLY85 |
| D | CYS86 |
| D | GLY87 |
| D | THR91 |
| D | ALA107 |
| D | VAL108 |
| D | GLN112 |
| D | ALA134 |
| D | ASP135 |
| D | ALA136 |
| D | ILE152 |
| D | SER154 |
| D | HIS157 |
| C | VAL17 |
| C | TYR21 |
| C | VAL36 |
| C | HIS37 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | binding site for residue TEX D 302 |
| Chain | Residue |
| C | TYR21 |
| C | TYR28 |
| C | LEU32 |
| C | HIS37 |
| D | GLU153 |
| D | CYS156 |
| D | HIS157 |
| D | GLU181 |
| D | SER182 |
| D | PHE196 |
| D | TYR200 |
| D | LEU232 |
| D | THR235 |
| D | LEU273 |
| site_id | AC9 |
| Number of Residues | 18 |
| Details | binding site for residue SAH E 301 |
| Chain | Residue |
| E | GLY85 |
| E | CYS86 |
| E | GLY87 |
| E | THR91 |
| E | ALA107 |
| E | VAL108 |
| E | GLN112 |
| E | ALA134 |
| E | ASP135 |
| E | ALA136 |
| E | ILE152 |
| E | SER154 |
| E | HIS157 |
| E | MET158 |
| F | VAL17 |
| F | TYR21 |
| F | VAL36 |
| F | HIS37 |
| site_id | AD1 |
| Number of Residues | 12 |
| Details | binding site for residue TEX E 302 |
| Chain | Residue |
| E | GLU153 |
| E | CYS156 |
| E | HIS157 |
| E | GLU181 |
| E | SER182 |
| E | PHE196 |
| E | TYR200 |
| E | LEU232 |
| E | LEU273 |
| F | TYR21 |
| F | TYR28 |
| F | LEU32 |
| site_id | AD2 |
| Number of Residues | 19 |
| Details | binding site for residue SAH F 301 |
| Chain | Residue |
| E | TYR21 |
| E | VAL36 |
| E | HIS37 |
| F | GLY85 |
| F | GLY87 |
| F | THR91 |
| F | ALA107 |
| F | VAL108 |
| F | GLN112 |
| F | ALA134 |
| F | ASP135 |
| F | ALA136 |
| F | MET137 |
| F | ILE152 |
| F | SER154 |
| F | HIS157 |
| F | MET158 |
| F | HOH408 |
| F | HOH415 |
| site_id | AD3 |
| Number of Residues | 15 |
| Details | binding site for residue TEX F 302 |
| Chain | Residue |
| E | TYR21 |
| E | TYR28 |
| E | VAL36 |
| E | HIS37 |
| F | GLU153 |
| F | CYS156 |
| F | HIS157 |
| F | GLU181 |
| F | SER182 |
| F | PHE196 |
| F | TYR200 |
| F | LEU232 |
| F | THR235 |
| F | MET236 |
| F | LEU273 |
| site_id | AD4 |
| Number of Residues | 18 |
| Details | binding site for residue SAH G 301 |
| Chain | Residue |
| G | GLY85 |
| G | CYS86 |
| G | GLY87 |
| G | ALA107 |
| G | VAL108 |
| G | GLN112 |
| G | ALA134 |
| G | ASP135 |
| G | ALA136 |
| G | MET137 |
| G | ILE152 |
| G | GLU153 |
| G | SER154 |
| G | HIS157 |
| H | VAL17 |
| H | TYR21 |
| H | VAL36 |
| H | HIS37 |
| site_id | AD5 |
| Number of Residues | 12 |
| Details | binding site for residue TEX G 302 |
| Chain | Residue |
| G | GLU153 |
| G | CYS156 |
| G | HIS157 |
| G | GLU181 |
| G | SER182 |
| G | PHE196 |
| G | TYR200 |
| G | LEU232 |
| G | MET236 |
| G | LEU273 |
| H | TYR21 |
| H | TYR28 |
| site_id | AD6 |
| Number of Residues | 18 |
| Details | binding site for residue SAH H 301 |
| Chain | Residue |
| G | VAL36 |
| G | HIS37 |
| H | GLY85 |
| H | CYS86 |
| H | GLY87 |
| H | THR91 |
| H | ALA107 |
| H | VAL108 |
| H | GLN112 |
| H | ALA134 |
| H | ASP135 |
| H | ALA136 |
| H | MET137 |
| H | ILE152 |
| H | GLU153 |
| H | SER154 |
| H | HIS157 |
| H | MET158 |
| site_id | AD7 |
| Number of Residues | 13 |
| Details | binding site for residue TEX H 302 |
| Chain | Residue |
| G | TYR28 |
| G | LEU32 |
| G | VAL36 |
| G | HIS37 |
| H | GLU153 |
| H | CYS156 |
| H | HIS157 |
| H | GLU181 |
| H | SER182 |
| H | PHE196 |
| H | TYR200 |
| H | LEU232 |
| H | THR235 |
| site_id | AD8 |
| Number of Residues | 19 |
| Details | binding site for residue SAH I 301 |
| Chain | Residue |
| I | GLY85 |
| I | CYS86 |
| I | GLY87 |
| I | THR91 |
| I | ALA107 |
| I | VAL108 |
| I | GLN112 |
| I | ALA134 |
| I | ASP135 |
| I | ALA136 |
| I | MET137 |
| I | ILE152 |
| I | SER154 |
| I | HIS157 |
| I | HOH401 |
| K | VAL17 |
| K | TYR21 |
| K | VAL36 |
| K | HIS37 |
| site_id | AD9 |
| Number of Residues | 15 |
| Details | binding site for residue TEX I 302 |
| Chain | Residue |
| I | GLU153 |
| I | CYS156 |
| I | HIS157 |
| I | GLU181 |
| I | SER182 |
| I | PHE196 |
| I | LEU232 |
| I | THR235 |
| I | MET236 |
| K | TYR21 |
| K | TYR28 |
| K | LEU32 |
| K | VAL36 |
| K | HIS37 |
| K | CYS38 |
| site_id | AE1 |
| Number of Residues | 14 |
| Details | binding site for residue SAH J 301 |
| Chain | Residue |
| J | GLY85 |
| J | CYS86 |
| J | GLY87 |
| J | ALA107 |
| J | VAL108 |
| J | GLN112 |
| J | ALA136 |
| J | ILE152 |
| J | GLU153 |
| J | SER154 |
| J | HIS157 |
| L | SER35 |
| L | VAL36 |
| L | HIS37 |
| site_id | AE2 |
| Number of Residues | 14 |
| Details | binding site for residue TEX J 302 |
| Chain | Residue |
| J | GLU153 |
| J | CYS156 |
| J | HIS157 |
| J | GLU181 |
| J | SER182 |
| J | PHE196 |
| J | TYR200 |
| J | LEU232 |
| J | THR235 |
| J | MET236 |
| J | LEU273 |
| L | TYR28 |
| L | HIS37 |
| L | CYS38 |
| site_id | AE3 |
| Number of Residues | 13 |
| Details | binding site for residue SAH K 301 |
| Chain | Residue |
| I | VAL36 |
| I | HIS37 |
| K | GLY85 |
| K | GLY87 |
| K | GLN112 |
| K | ALA134 |
| K | ASP135 |
| K | ALA136 |
| K | ILE152 |
| K | GLU153 |
| K | SER154 |
| K | HIS157 |
| K | MET158 |
| site_id | AE4 |
| Number of Residues | 14 |
| Details | binding site for residue TEX K 302 |
| Chain | Residue |
| I | TYR28 |
| I | LEU32 |
| I | VAL36 |
| I | HIS37 |
| I | CYS38 |
| K | GLU153 |
| K | CYS156 |
| K | HIS157 |
| K | GLU181 |
| K | SER182 |
| K | PHE196 |
| K | LEU232 |
| K | THR235 |
| K | PHE279 |
| site_id | AE5 |
| Number of Residues | 18 |
| Details | binding site for residue SAH L 301 |
| Chain | Residue |
| J | VAL17 |
| J | TYR21 |
| J | VAL36 |
| J | HIS37 |
| L | GLY85 |
| L | GLY87 |
| L | ALA107 |
| L | VAL108 |
| L | GLN112 |
| L | ALA134 |
| L | ASP135 |
| L | ALA136 |
| L | MET137 |
| L | ILE152 |
| L | GLU153 |
| L | SER154 |
| L | HIS157 |
| L | MET158 |
| site_id | AE6 |
| Number of Residues | 13 |
| Details | binding site for residue TEX L 302 |
| Chain | Residue |
| J | TYR21 |
| J | TYR28 |
| J | LEU32 |
| J | HIS37 |
| L | GLU153 |
| L | CYS156 |
| L | HIS157 |
| L | GLU181 |
| L | SER182 |
| L | PHE196 |
| L | TYR200 |
| L | LEU232 |
| L | LEU273 |
| site_id | AE7 |
| Number of Residues | 19 |
| Details | binding site for residue SAH M 301 |
| Chain | Residue |
| M | GLY85 |
| M | CYS86 |
| M | GLY87 |
| M | THR91 |
| M | ALA107 |
| M | VAL108 |
| M | GLN112 |
| M | ALA134 |
| M | ASP135 |
| M | ALA136 |
| M | MET137 |
| M | ILE152 |
| M | SER154 |
| M | HIS157 |
| M | MET158 |
| N | VAL17 |
| N | TYR21 |
| N | VAL36 |
| N | HIS37 |
| site_id | AE8 |
| Number of Residues | 14 |
| Details | binding site for residue TEX M 302 |
| Chain | Residue |
| M | GLU153 |
| M | CYS156 |
| M | HIS157 |
| M | GLU181 |
| M | SER182 |
| M | PHE196 |
| M | LEU232 |
| M | MET236 |
| M | LEU273 |
| N | TYR21 |
| N | TYR28 |
| N | LEU32 |
| N | VAL36 |
| N | HIS37 |
| site_id | AE9 |
| Number of Residues | 15 |
| Details | binding site for residue SAH N 301 |
| Chain | Residue |
| M | VAL36 |
| M | HIS37 |
| N | GLY85 |
| N | CYS86 |
| N | GLY87 |
| N | ALA107 |
| N | VAL108 |
| N | GLN112 |
| N | ALA134 |
| N | ASP135 |
| N | ALA136 |
| N | ILE152 |
| N | SER154 |
| N | HIS157 |
| N | MET158 |
| site_id | AF1 |
| Number of Residues | 12 |
| Details | binding site for residue TEX N 302 |
| Chain | Residue |
| M | TYR28 |
| M | LEU32 |
| M | HIS37 |
| N | GLU153 |
| N | CYS156 |
| N | HIS157 |
| N | GLU181 |
| N | SER182 |
| N | PHE196 |
| N | TYR200 |
| N | LEU232 |
| N | LEU273 |
| site_id | AF2 |
| Number of Residues | 17 |
| Details | binding site for residue SAH O 301 |
| Chain | Residue |
| O | GLY85 |
| O | CYS86 |
| O | GLY87 |
| O | THR91 |
| O | ALA107 |
| O | VAL108 |
| O | GLN112 |
| O | ALA134 |
| O | ASP135 |
| O | ALA136 |
| O | MET137 |
| O | ILE152 |
| O | SER154 |
| O | HIS157 |
| P | VAL17 |
| P | VAL36 |
| P | HIS37 |
| site_id | AF3 |
| Number of Residues | 15 |
| Details | binding site for residue TEX O 302 |
| Chain | Residue |
| O | GLU153 |
| O | CYS156 |
| O | HIS157 |
| O | GLU181 |
| O | SER182 |
| O | PHE196 |
| O | TYR200 |
| O | LEU232 |
| O | MET236 |
| O | LEU273 |
| P | TYR21 |
| P | TYR28 |
| P | LEU32 |
| P | VAL36 |
| P | HIS37 |
| site_id | AF4 |
| Number of Residues | 18 |
| Details | binding site for residue SAH P 301 |
| Chain | Residue |
| O | VAL17 |
| O | TYR21 |
| O | VAL36 |
| O | HIS37 |
| P | GLY85 |
| P | GLY87 |
| P | THR91 |
| P | ALA107 |
| P | VAL108 |
| P | GLN112 |
| P | ALA134 |
| P | ASP135 |
| P | ALA136 |
| P | MET137 |
| P | ILE152 |
| P | SER154 |
| P | HIS157 |
| P | MET158 |
| site_id | AF5 |
| Number of Residues | 13 |
| Details | binding site for residue TEX P 302 |
| Chain | Residue |
| O | TYR21 |
| O | TYR28 |
| O | LEU32 |
| O | HIS37 |
| P | GLU153 |
| P | CYS156 |
| P | GLU181 |
| P | SER182 |
| P | PHE196 |
| P | TYR200 |
| P | LEU232 |
| P | THR235 |
| P | LEU273 |
| site_id | AF6 |
| Number of Residues | 19 |
| Details | binding site for residue SAH Q 301 |
| Chain | Residue |
| Q | GLY85 |
| Q | GLY87 |
| Q | THR91 |
| Q | ALA107 |
| Q | VAL108 |
| Q | GLN112 |
| Q | ALA134 |
| Q | ASP135 |
| Q | ALA136 |
| Q | MET137 |
| Q | ILE152 |
| Q | GLU153 |
| Q | SER154 |
| Q | HIS157 |
| Q | MET158 |
| R | VAL17 |
| R | TYR21 |
| R | VAL36 |
| R | HIS37 |
| site_id | AF7 |
| Number of Residues | 14 |
| Details | binding site for residue TEX Q 302 |
| Chain | Residue |
| Q | GLU153 |
| Q | CYS156 |
| Q | HIS157 |
| Q | GLU181 |
| Q | SER182 |
| Q | PHE196 |
| Q | TYR200 |
| Q | LEU232 |
| Q | THR235 |
| R | TYR21 |
| R | TYR28 |
| R | VAL36 |
| R | HIS37 |
| R | CYS38 |
| site_id | AF8 |
| Number of Residues | 15 |
| Details | binding site for residue SAH R 301 |
| Chain | Residue |
| Q | VAL36 |
| Q | HIS37 |
| R | GLY85 |
| R | GLY87 |
| R | VAL108 |
| R | GLN112 |
| R | ALA134 |
| R | ASP135 |
| R | ALA136 |
| R | ILE152 |
| R | GLU153 |
| R | SER154 |
| R | HIS157 |
| R | MET158 |
| R | HOH403 |
| site_id | AF9 |
| Number of Residues | 13 |
| Details | binding site for residue TEX R 302 |
| Chain | Residue |
| Q | TYR28 |
| Q | LEU32 |
| Q | HIS37 |
| R | GLU153 |
| R | CYS156 |
| R | HIS157 |
| R | LEU180 |
| R | GLU181 |
| R | SER182 |
| R | PHE196 |
| R | TYR200 |
| R | LEU232 |
| R | THR235 |
