Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5GIP

Crystal structure of box C/D RNP with 13 nt guide regions and 11 nt substrates

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0030515	molecular_function	snoRNA binding
A	0031428	cellular_component	box C/D methylation guide snoRNP complex
A	0032040	cellular_component	small-subunit processome
B	0005515	molecular_function	protein binding
B	0030515	molecular_function	snoRNA binding
B	0031428	cellular_component	box C/D methylation guide snoRNP complex
B	0032040	cellular_component	small-subunit processome
C	0001682	biological_process	tRNA 5'-leader removal
C	0003723	molecular_function	RNA binding
C	0003735	molecular_function	structural constituent of ribosome
C	0004526	molecular_function	ribonuclease P activity
C	0005737	cellular_component	cytoplasm
C	0005840	cellular_component	ribosome
C	0006412	biological_process	translation
C	0008033	biological_process	tRNA processing
C	0019843	molecular_function	rRNA binding
C	0042254	biological_process	ribosome biogenesis
C	1990904	cellular_component	ribonucleoprotein complex
D	0001682	biological_process	tRNA 5'-leader removal
D	0003723	molecular_function	RNA binding
D	0003735	molecular_function	structural constituent of ribosome
D	0004526	molecular_function	ribonuclease P activity
D	0005737	cellular_component	cytoplasm
D	0005840	cellular_component	ribosome
D	0006412	biological_process	translation
D	0008033	biological_process	tRNA processing
D	0019843	molecular_function	rRNA binding
D	0042254	biological_process	ribosome biogenesis
D	1990904	cellular_component	ribonucleoprotein complex
E	0000494	biological_process	box C/D sno(s)RNA 3'-end processing
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0006338	biological_process	chromatin remodeling
E	0006364	biological_process	rRNA processing
E	0008033	biological_process	tRNA processing
E	0008168	molecular_function	methyltransferase activity
E	0008649	molecular_function	rRNA methyltransferase activity
E	0031167	biological_process	rRNA methylation
E	0031428	cellular_component	box C/D methylation guide snoRNP complex
E	0032259	biological_process	methylation
E	1990259	molecular_function	histone H2AQ104 methyltransferase activity
F	0000494	biological_process	box C/D sno(s)RNA 3'-end processing
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0006338	biological_process	chromatin remodeling
F	0006364	biological_process	rRNA processing
F	0008033	biological_process	tRNA processing
F	0008168	molecular_function	methyltransferase activity
F	0008649	molecular_function	rRNA methyltransferase activity
F	0031167	biological_process	rRNA methylation
F	0031428	cellular_component	box C/D methylation guide snoRNP complex
F	0032259	biological_process	methylation
F	1990259	molecular_function	histone H2AQ104 methyltransferase activity
K	0005515	molecular_function	protein binding
K	0030515	molecular_function	snoRNA binding
K	0031428	cellular_component	box C/D methylation guide snoRNP complex
K	0032040	cellular_component	small-subunit processome
L	0005515	molecular_function	protein binding
L	0030515	molecular_function	snoRNA binding
L	0031428	cellular_component	box C/D methylation guide snoRNP complex
L	0032040	cellular_component	small-subunit processome
M	0001682	biological_process	tRNA 5'-leader removal
M	0003723	molecular_function	RNA binding
M	0003735	molecular_function	structural constituent of ribosome
M	0004526	molecular_function	ribonuclease P activity
M	0005737	cellular_component	cytoplasm
M	0005840	cellular_component	ribosome
M	0006412	biological_process	translation
M	0008033	biological_process	tRNA processing
M	0019843	molecular_function	rRNA binding
M	0042254	biological_process	ribosome biogenesis
M	1990904	cellular_component	ribonucleoprotein complex
N	0001682	biological_process	tRNA 5'-leader removal
N	0003723	molecular_function	RNA binding
N	0003735	molecular_function	structural constituent of ribosome
N	0004526	molecular_function	ribonuclease P activity
N	0005737	cellular_component	cytoplasm
N	0005840	cellular_component	ribosome
N	0006412	biological_process	translation
N	0008033	biological_process	tRNA processing
N	0019843	molecular_function	rRNA binding
N	0042254	biological_process	ribosome biogenesis
N	1990904	cellular_component	ribonucleoprotein complex
O	0000494	biological_process	box C/D sno(s)RNA 3'-end processing
O	0003723	molecular_function	RNA binding
O	0005515	molecular_function	protein binding
O	0006338	biological_process	chromatin remodeling
O	0006364	biological_process	rRNA processing
O	0008033	biological_process	tRNA processing
O	0008168	molecular_function	methyltransferase activity
O	0008649	molecular_function	rRNA methyltransferase activity
O	0031167	biological_process	rRNA methylation
O	0031428	cellular_component	box C/D methylation guide snoRNP complex
O	0032259	biological_process	methylation
O	1990259	molecular_function	histone H2AQ104 methyltransferase activity
P	0000494	biological_process	box C/D sno(s)RNA 3'-end processing
P	0003723	molecular_function	RNA binding
P	0005515	molecular_function	protein binding
P	0006338	biological_process	chromatin remodeling
P	0006364	biological_process	rRNA processing
P	0008033	biological_process	tRNA processing
P	0008168	molecular_function	methyltransferase activity
P	0008649	molecular_function	rRNA methyltransferase activity
P	0031167	biological_process	rRNA methylation
P	0031428	cellular_component	box C/D methylation guide snoRNP complex
P	0032259	biological_process	methylation
P	1990259	molecular_function	histone H2AQ104 methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue SAH E 301

Chain	Residue
E	TYR82
E	ALA134
E	ASP153
E	ILE154
E	ALA155
E	GLN156
G	U26
E	GLY84
E	ALA86
E	THR89
E	THR90
E	GLU108
E	PHE109
E	ALA132
E	ASP133

site_id	AC2
Number of Residues	14
Details	binding site for residue SAH F 301

Chain	Residue
F	TYR82
F	GLY84
F	ALA86
F	THR90
F	GLU108
F	PHE109
F	SER110
F	ASP133
F	ALA134
F	ASP153
F	ILE154
F	ALA155
F	GLN156
H	U26

site_id	AC3
Number of Residues	15
Details	binding site for residue SAH O 301

Chain	Residue
O	LYS60
O	TYR82
O	GLY84
O	ALA86
O	THR90
O	GLU108
O	PHE109
O	ALA132
O	ASP133
O	ALA134
O	ASP153
O	ILE154
O	ALA155
O	GLN156
Q	U26

site_id	AC4
Number of Residues	15
Details	binding site for residue SAH P 301

Chain	Residue
P	ARG58
P	TYR82
P	GLY84
P	THR89
P	THR90
P	GLU108
P	PHE109
P	ALA132
P	ASP133
P	ALA134
P	ASP153
P	ILE154
P	ALA155
P	GLN156
R	U26

Functional Information from PROSITE/UniProt

site_id	PS00566
Number of Residues	15
Details	FIBRILLARIN Fibrillarin signature. GKAYGVEFSpRvvRE

Chain	Residue	Details
E	GLY102-GLU116

site_id	PS01082
Number of Residues	18
Details	RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CdekkIPYvyVsSKkaLG

Chain	Residue	Details
C	CYS73-GLY90

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING:

Chain	Residue	Details
E	THR89
O	GLU108
O	ASP133
O	ASP153
P	THR89
P	GLU108
P	ASP133
P	ASP153
E	GLU108
E	ASP133
E	ASP153
F	THR89
F	GLU108
F	ASP133
F	ASP153
O	THR89

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)